Tag: 35212-85-2

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35212-85-2,Methyl 3-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

EXAMPLE 62 3-(Dimethylaminomethyleneamino)benzo[b]thiophene-2-carboxylic acid methyl ester A mixture of 3.38 g (16.32 mmol) of methyl 3-aminobenzo[b]thiophene-2-carboxylate (J. Org. Chem. 37, 3224 (1972)) in 8 mL of N,N,-dimethylformamide dimethyl acetal is heated at reflux temperature for 2 hours, then cooled to room temperature. The solid is collected by filtration, washing with hexane and ethyl acetate to provide 3.96 g (93%) of a white solid, mp 73-74 C. 1H-NMR (DMSO-d6): delta 3.06 (s, 6H), 3.75 (s, 3H), 7.47 (t, 1H), 7.50 (t, 1H), 7.78 (d, 1H), 7,82-7.89 (m, 2H).

35212-85-2 Methyl 3-aminobenzo[b]thiophene-2-carboxylate 874720, abenzothiophene compound, is more and more widely used in various.

Reference£º
Patent; American Home Products Corporation; US2001/51620; (2001); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35212-85-2,Methyl 3-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

A suspension of 3-amino-benzo[b]thiophene-2-carboxylic acid methyl ester (1.03 g, 5.0 mmol) and chloroformamidine hydrochloride (800 mg, 7.0 mmol) in diglyme (8 mL) were heated at 160 C. for 1 h. The resulting suspension was cooled to rt and filtered, and the collected solid was suction dried to give the title compound (1.14 g, 90%). 1H NMR (DMSO-d6): 8.06 (d, J=7.9 Hz, 1H), 7.89 (d, J=8.1 Hz, 1H), 7.73-7.47 (m, 2H), 7.45-7.39 (m, 1H), 7.38-7.33 (m, 1H), 7.18 (s, 0.6H), 7.05 (s, 0.6H), 6.92 (s, 0.6H).

As the paragraph descriping shows that 35212-85-2 is playing an increasingly important role.

Reference£º
Patent; Chavez, Frank; Curtis, Michael P.; Edwards, James P.; Gomez, Laurent; Grice, Cheryl A.; Kearney, Aaron M.; Savall, Brad M.; US2008/15200; (2008); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem