Tag: M.W:100-200

Reference of 22913-24-2, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 22913-24-2, Methyl benzo[b]thiophene-2-carboxylate, introducing its new discovery.

Synthesis and Antitubercular Activity of New Benzo[b]thiophenes

In vitro and ex vivo efficacies of four series of benzo[b]thiophene-2-carboxylic acid derivatives were studied against Mycobacterium tuberculosis H37Ra (MTB). Benzo[b]thiophenes were also tested in vitro against multidrug resistant Mycobacterium tuberculosis H37Ra (MDR-MTB), and 7b was found to be highly active against A- and D-MDR-MTB/MTB (MIC ranges 2.73-22.86 mug/mL). The activity of all benzo[b]thiophenes against M. bovis BCG (BCG) was also assessed grown under aerobic and under conditions of oxygen depletion. Compounds 8c and 8g showed significant activity with MICs of 0.60 and 0.61 mug/mL against dormant BCG. The low cytotoxicity and high selectivity index data against human cancer cell lines, HeLa, Panc-1, and THP-1 indicate the potential importance of the development of benzo[b]thiophene-based 1,3-diketones and flavones as lead candidates to treat mycobacterial infections. Molecular docking studies into the active site of DprE1 (Decaprenylphosphoryl-beta-d-ribose-2?-epimerase) enzyme revealed a similar binding mode to native ligand in the crystal structure thereby helping to understand the ligand-protein interactions and establish a structural basis for inhibition of MTB. In summary, its good activity in in vitro and ex vivo model, as well as its activity against multidrug-resistant M. tuberculosis H37Ra in a potentially latent state, makes 7b an attractive drug candidate for the therapy of tuberculosis.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 22913-24-2. In my other articles, you can also check out more blogs about 22913-24-2

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Safety of Methyl benzo[b]thiophene-2-carboxylate, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 22913-24-2, name is Methyl benzo[b]thiophene-2-carboxylate. In an article£¬Which mentioned a new discovery about 22913-24-2

Design, Synthesis, and Pharmacological Evaluation of First-in-Class Multitarget N-Acylhydrazone Derivatives as Selective HDAC6/8 and PI3Kalpha Inhibitors

Targeting histone deacetylases (HDACs) and phosphatidylinositol 3-kinases (PI3Ks) is a very promising approach for cancer treatment. This manuscript describes the design, synthesis, in vitro pharmacological profile, and molecular modeling of a novel class of N-acylhydrazone (NAH) derivatives that act as HDAC6/8 and PI3Kalpha dual inhibitors. The surprising selectivity for PI3Kalpha may be related to differences in the conformation in the active site. Cellular studies showed that these compounds act in HDAC6 inhibition and the PI3/K/AKT/mTOR pathway. The compounds that are selective for inhibition of HDAC6/8 and inhibit PI3Kalpha show potential for the treatment of cancer.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 22913-24-2, help many people in the next few years.Safety of Methyl benzo[b]thiophene-2-carboxylate

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Synthetic Route of 130-03-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 130-03-0, Benzo[b]thiophen-3(2H)-one, introducing its new discovery.

Application of directed metallation in synthesis, part 2: An expedient synthesis of methoxybenzo[b]thiophenes

A short, simple and expedient synthesis of substituted benzo[b]thiophenes involving directed ortho lithiation-side-chain deprotonation-cyclisation-reduction is described. This method is a valuable improvement over earlier syntheses of the same class of compounds, both with respect to the number of steps and overall yields.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 130-03-0. In my other articles, you can also check out more blogs about 130-03-0

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Quality Control of 6-Methylbenzo[b]thiophene. Introducing a new discovery about 16587-47-6, Name is 6-Methylbenzo[b]thiophene

Prediction of gas chromatographic retention times and indices of sulfur compounds in light cycle oil

Ninety sulfur compounds consisting of mercaptans, sulfides and thiophenes, were identified in a fluid-catalytic-cracking light cycle oil using gas chromatography with atomic emission detection. Their retention times and indices were correlated with molecular descriptors generated from their molecular structures. The best seven- and eight-parameter multi-linear regression models showed good predictive ability. The descriptors involved in the models reflect the geometrical, topological, and electronic properties of the molecules, related to the interactions between the solute and the stationary phase. For the 34 thiophenic sulfur compounds (benzothiophenes and dibenzothiophenes) of most interest in petroleum processing, another two five-parameter multi-linear models were developed for retention times and indices with standard errors s = 0.61 and 1.63, respectively. Such models for retention times and/or indices can be used for identification of unknown chromatographic peaks by matching their retention times or indices with those of sulfur compounds of known molecular structure when the corresponding chemical standards are unavailable.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Electric Literature of 22913-24-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.22913-24-2, Name is Methyl benzo[b]thiophene-2-carboxylate, molecular formula is C10H8O2S. In a article£¬once mentioned of 22913-24-2

Determination of partition coefficient of benzo[b]thiophenes by reversed-phase high-performance liquid chromatography

The octanol-water partition coefficients (log P) for a series of benzo[b]thiophenes were estimated by high performance liquid chromatography on a C18 reversed-phase column, using methanol-water as mobile phase. Measured values for the benzo[b]thiophenes ranged from 2.08 to 4.18. The experimental log P values showed good correlation with those predicted by the Dixon’s method.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 22913-24-2

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Recommanded Product: 66490-33-3. Introducing a new discovery about 66490-33-3, Name is 4-Chlorobenzo[b]thiophene

Synthesis and S(N)V Reactions of 2-(Haloethenyl)benzothiophene 1,1-Dioxides

The synthesis of a variety of 2-(haloethenyl)benzothiophenes from both substituted and unsubstituted benzothiophenes is described.Their corresponding 1,1-dioxides exhibited versatile reactivity via addition/conjugated elimination and direct substitution mechanisms with amine,thio, and alkoxy nucleophiles in good yield

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem