Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17402-83-4,Benzo[b]thiophen-4-amine,as a common compound, the synthetic route is as follows.

General procedure: 2 ml of pyridine, 257 mg of N-[3-(dimethylamino)propyl]-N?-ethylcarbodiimide hydrochloride and 223 mg of benzo[B]thiophen-4-ylamine are added to a solution of 250 mg of sodium [4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetate prepared in stage 2 of example 1, in 2 ml of N,N-dimethylformamide. The reaction mixture is stirred at ambient temperature for 15 hours, and then concentrated under reduced pressure. Water and ethyl acetate are added and the resulting mixture is thus stirred for 30 minutes. The precipitate formed is filtered off, and rinsed with water, ethyl ether and petroleum ether. The solid obtained is dried under vacuum. 262 mg of N-(1-benzothiophen-4-yl)-2-[4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidin-2-yl]acetamide are obtained in the formed of an off-white solid

17402-83-4, As the paragraph descriping shows that 17402-83-4 is playing an increasingly important role.

Reference£º
Patent; Sanofi; Cali, Jean – Christophe; Sertar, Victor; Array, Frank; Carlson, Carl Andreas; Shio, Laulan; Thompson, Fabienne; (178 pag.)JP5680638; (2015); B2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a solution of dithioacetals 3 or 4 (1 mmol) in dry THF (20 mL), cooled to -78 C, was added n-BuLi (1.4 mmol, 2.7 M solution in hexanes). The resulting mixture was stirred at this temperature for 30 min under argon atmosphere. Then, the corresponding aldehyde (Ar2-CHO) (1.1 mmol) in THF (10 mL) was added. The reaction mixture was stirred for 3 h at -78 C, warmed to room temperature and stirred for 4 h at this temperature. The mixture was diluted with ethyl acetate (25 mL), washed with a saturated aqueous solution of NH4Cl (30 mL), and then water (20 mL). The organic layer was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The crude product was purified using a silica gel column chromatography with 10% acetone in petroleum ether as eluent., 3541-37-5

The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Czarnecka, Anna; Kowalska, Emilia; Bodzioch, Agnieszka; Skalik, Joanna; Koprowski, Marek; Owsianik, Krzysztof; Ba?czewski, Piotr; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 1229 – 1237;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: A mixture of appropriate piperazine base (i-vi, 1 mmol), aldehydes (1a-1d, 1 mmol) and around 1.1-1.3 mmol quantity of TMSCN was taken in 5-8 mL water. After stirring for a while, 10 mg Indium powder was added to the reaction mixture and the resulted reaction mass was allowed to stir at room temperature for 45 min-2.5 h. After the completion ofthe reaction as monitored by Thin Layer Chro-matography using toluene: acetone (8:2) or ethyl acetate: n-nexane (8:2) solvent system, after treatment with diethyl ether or ethyl acetate, solution was filtered and washed with water and brine followed by anhydrous sodium sulphate treatment to dry. The residue was purified by silica gel column chromatography (ethyl acetate: n-hexane) to afford compounds 2i-5vi., 3541-37-5

As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Article; Patel, Rahul V.; Patel, Jigar K.; Nile, Shivraj H.; Park, Se Won; Letters in drug design and discovery; vol. 10; 5; (2013); p. 462 – 470;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1127-35-1, Benzo[b]thiophene-3(2H)-one 1,1-Dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Pd(OAc)2 (0.025 mmol, 5.6 mg), PCy¡¤HBF4 (0.05 mmol,18.5 mg), 1a (0.25 mmol, 45.5 mg), and KOtBu (0.75 mmol,84 mg) were added to a Schlenk 8ask. And the mixture wasdissolved in 1 mL of toluene under a nitrogen atmosphere.*e reaction mixture was stirred at 110C for 24 h. *en,ethyl acetate was used to dissolve the mixtupe as much aspossible (except for inorganic salt). Celatom was used to;lter undissolved substance. After this, the solvent wasevaporated under vacuum and the mixture was analyzed byGC or puri;ed by column chromatography on silica gel(petpoleum ethep: ethyl aceta3te:1) to a5ord product 1cas a pale yellow solid.

1127-35-1, The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Hailong; Li, Wenjing; Fu, Haiyan; Chen, Hua; Li, Ruixiang; Li, Yu; Journal of Chemistry; vol. 2019; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

95-15-8, Thianaphthene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To an ice cooled solution of N-methylformanilide (2.2 mmol) was added dropwise diphosphoryl chloride (2.2 mmol). The solution was stirred for 30 min at 0 C, and then 1,2-dimethoxybenzene (276.3 mg, 2 mmol) in DMF (1.0 mL) was added dropwise. After being stirred for 10 h at 100 C, I2 (1015.2 mg, 4 mmol), aq NH3 (4 mL, 28-30%) and THF (1 mL) were added to the reaction mixture. The obtained mixture was stirred for 3 h at rt. After the reaction, the mixture was poured into aq satd Na2SO3 solution and extracted with CHCl3 (3¡Á20 mL). The organic layer was dried over Na2SO4, filtered, and evaporated. The product was purified by flash short column chromatography (Hexane:AcOEt=3:1) to afford 3,4-dimethoxybenzonitrile as a white solid in 92% yield., 95-15-8

As the paragraph descriping shows that 95-15-8 is playing an increasingly important role.

Reference£º
Article; Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo; Tetrahedron; vol. 68; 24; (2012); p. 4588 – 4595;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5381-20-4

A mixture of thianaphthene-3-carboxaldehyde (0.2 g, 1.23 mmol), acetylacetone (0.25 mL, 2.47 mmol) and aqueous ammonium hydroxide solution (38-40%, 0.12 mL) in ethanol (1 mL) was heated to 90C and left to stir for 16 hours. The mixture was allowed to cool to RT and was then poured into 10 ml of cold water. The precipitate formed was filtered off, dried and washed with cold diethyl ether. The desired product was obtained as a strongly yellow solid (0.193 g, 48 %). 1H-NMR (400 MHz, DMSO-d6) delta = 2.17 (s, 6H), 2.29 (s, 6H), 5.52 (s, 1H), 7.23 (s, 1H), 7.33 (dt 2H), 7.88 (d, 1H), 8.12 (d, 1H), 9.08 (s, 1H). HPLC-MS: Rt 3.668 min, m/z 192.1 (MH+-134). The following examples were synthesized according to Method G.

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Patent; Oncostellae, S.L.; KURZ, Guido; CAMACHO GOMEZ, Juan; (123 pag.)EP3480201; (2019); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

346592-74-3, 7-Fluorobenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1 3-[(7-Fluoro-benzo[b]thiophen-2-yl)-hydroxy-methyl]-3-(tetrahydro-pyran-4-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester To a solution of 7-fluoro-benzothiophene (0.22 g, 1.44 mmoles) in anhydrous tetrahydrofuran (10 ml) at -78 C. was added dropwise a solution of n-BuLi in hexane (1.6M, 0.9 ml, 1.44 mmoles). The reaction mixture was stirred at -78 C. for one hour, and then a solution of 3-formyl-3-(tetrahydro-pyran-4-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (0.3 g, 1.01 mmoles) in anhydrous tetrahydrofuran (5 ml) was then added. The reaction mixture was stirred at -78 C. for 3 hours, quenched with saturated aqueous ammonium chloride, and partitioned between ethyl acetate and saturated aqueous ammonium chloride solution. The organic phase was washed with brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel chromatography (10 to 45% ethyl acetate in hexane) to yield 3-[(7-Fluoro-benzo[b]thiophen-2-yl)-hydroxy-methyl]-3-(tetrahydro-pyran-4-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester as a colorless semisolid (0.138 g, 30%). MS=450 [M+H]+., 346592-74-3

346592-74-3 7-Fluorobenzo[b]thiophene 21866059, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Roche Palo Alto LLC; US2009/318493; (2009); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

95-15-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95-15-8,Thianaphthene,as a common compound, the synthetic route is as follows.

To a 13¡Á100 mm borosilicate glass heavy wall test tube was added benzothiophene (73.8 mg, 0.55 mmol). A stock solution of Pd(OAc)2 (16.8 mg, 0.075 mmol, 75 mM) and BQ (8.1 mg, 0.075 mmol, 75 mM) in 1.0 mL DMSO was created. A stock solution of Cu(OAc)2.H2O (57.1 mg, 0.286 mmol, 143 mM) and phd (60.1 mg, 0.286 mmol, 143 mM) in 2.0 mL DMSO was created. Then, 100 muL DMSO, followed by 220 muL (0.0165 mmol) of the Pd(OAc)2/BQ stock solution, and 115 muL (0.0164 mmol) of the Cu(OAc)2.H2O/phd stock solution were added to the test tube. The test tube with reaction mixture was placed on an orbital mixing block with heating element. The mixing block was sealed, purged with O2 for five minutes, cooling water was turned on, and then the block was heated to 120 C. under 1 atm O2 with shaking for 48 hours. After 48 hours, the shaking was stopped, the block was depressurized, and the reaction test tube was removed and allowed to cool. An aliquot of a stock solution of 1,3,5-trimethoxybenzene in THF was added to the reaction mixture, and the DMSO/THF mixture was filtered through the Celite, and then the Celite was washed once more with THF. The filtrate was diluted with additional THF, and then it was shaken so that everything was evenly mixed.

As the paragraph descriping shows that 95-15-8 is playing an increasingly important role.

Reference£º
Patent; Wisconsin Alumni Research Foundation; Stahl, Shannon; Tereniak, Stephen; (42 pag.)US2019/210993; (2019); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6314-28-9,Benzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.

6314-28-9, General procedure: The DCC (1.2 equiv) was added to the solution of caudatin(0.2 mmol), DMAP (0.2 equiv), and appropriate carboxylic acid (1.2 equiv) in anhydrous CH2Cl2 (8 mL) at 0 C.The resulting mixture was stirred at room temperature until the starting material was not observed by TLC. The reaction mixture was filtered, and the residue was washed with CH2Cl2 (210 mL). Then, the CH2Cl2 solution was washed with 5% HCl (330 mL), saturated NaHCO3 (330 mL) and saturated NaCl (330 mL), respectively. Subsequently, the organic layer was dried by Na2SO4 and concentrated to dryness under reduced pressure. At last, the residue was purified by column chromatography over the silica gel with petroleum ether/acetone (60:40 – 95:5) to yield the pure target compounds.

6314-28-9 Benzo[b]thiophene-2-carboxylic acid 95864, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Wang, Li-Jun; Chen, Hao; Ma, Yun-Bao; Huang, Xiao-Yan; Geng, Chang-An; Zhang, Xue-Mei; Chen, Ji-Jun; Medicinal Chemistry; vol. 11; 2; (2015); p. 165 – 179;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

5381-20-4, General procedure: Amixture of the heterocyclic salt I1-I16 (2.5 mmol), aldehyde (7.5 mmol, 3 molar equiv, unlessotherwise stated) and piperidine (0.50 mL, 5 mmol, 2 molar equiv) in EtOH (25 mL) was heatedunder reflux for 2.5 h. After cooling to room temperature, the precipitated solid was collectedby filtration, washed with EtOH (2 ¡Á 5 mL) and Et2O (2 ¡Á 5 mL) and dried. The crude iodidesalt was either purified through a recrystallization from a suitable solvent (as indicated below)to give an analytically pure sample, or subjected to anion exchange to bromide or chloride, asdescribed below. Procedure for anion exchange: Ion-exchange resin (Amberlite IRA-402, Cl- form, or AmberliteIRA-400, Br- form, about 20 mmol equiv) was thoroughly rinsed with a mixture of MeCN andMeOH (1:1, v/v) and charged into a short glass column. The dye (iodide salt) was dissolvedin a minimal amount of a mixture of MeCN and MeOH (1:1, v/v) and loaded in the column. Theproduct was then eluted with the same solvent mixture (about 50 mL). The solvents wereremoved in vacuo and the residue was recrystallized from a suitable solvent (as indicatedbelow), to give an analytically pure dye.

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Xie, Xiao; Zuffo, Michela; Teulade-Fichou, Marie-Paule; Granzhan, Anton; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 1872 – 1889;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem