Tag: M.W:100-200

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 43 (1.62 g, 10 mmol) was weighed.N-bromosuccinimide (1.78 g, 10 mmol) was added to a three-necked flask and 20 mL of carbon tetrachloride was added.Irradiate with a 200w incandescent bulb and react at room temperature for 2 hours. Filter out the white solid,Concentrate the liquid. 2.2 g (92%) of a colorless transparent liquid were obtained., 5381-20-4

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Shanghai Yilishe Biological Co., Ltd.; Zhang Lihai; Gao Zhichao; Huang Ximing; Liu Hui; Hu Min; Jiang Yan; (72 pag.)CN108250058; (2018); A;,
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Benzothiophene | C8H6S – PubChem

95-15-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95-15-8,Thianaphthene,as a common compound, the synthetic route is as follows.

In the DCM solvent, in the presence of potassium acetate, benzothiophene (11) was brominated using bromine the benzothiophene. A white solid of compound (12) was obtained in a yield of 100%. In addition, equation (1) when manufacturing the compound shown, compound (11) gives the desired compound X can be replaced.

95-15-8 Thianaphthene 7221, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; YOKOHAMA NATIONAL UNIVERSITY; YOKOYAMA, YASUSHI; NAKAGAWA, TETSUYA; TAKEUCHI, SAKIKO; (17 pag.)JP2017/160159; (2017); A;,
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Benzothiophene | C8H6S – PubChem

130-03-0, Benzo[b]thiophen-3(2H)-one is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred mixture of ketone 1a or 1b (3 mmol) and diarylpropargylic alcohols 2a-e (3 ml) in acetonitrile (3 ml) the corresponding catalyst (Table 1) was added and the reaction mixture was refluxed under argon for 1 h. After cooling, the solvent was distilled off in vacuo. The residue was purified by recrystallization from the corresponding solvent or by chromatography on silica gel using the light petroleum/ethyl acetate (8:1) system as an eluent., 130-03-0

As the paragraph descriping shows that 130-03-0 is playing an increasingly important role.

Reference£º
Article; Shirinian, Valerii Z.; Zavarzin, Igor V.; Leonova, Evgeniya S.; Markosyan, Ashot I.; Mendeleev Communications; vol. 25; 4; (2015); p. 262 – 263;,
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Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, Compound 1 (200.0 mg, 0.46 mmol) and thianaphthene-3-carboxaldehyde(186.5 mg, 1.14 mmol) were dissolved in benzene (40 mL).Acetic acid (400 muL) and piperidine (400 muL) were added. The reactionmixture was refluxed using Dean-Stark apparatus until compound 1 wasconsumed. After the reaction was completed, it was extracted withCH2Cl2 and water. The organic layer was collected and dried with sodiumsulfate, evaporated under reduced pressure. The product waspurified by silica gel column chromatography using n-hexane-CH2Cl2(1:2) as mobile phase. Fractions containing compound 3 were collected,then the solvent was removed under reduced pressure (90.0 mg, 27%).MALDI TOF (m/z) Calc. 725.23, Found: 725.84 [M+]. 1H NMR(500 MHz, CDCl3) deltaH 8.09 (d, J=7.9 Hz, 2H, Ar-CH), 7.91 (d,J=7.9 Hz, 2H, Ar-CH), 7.88 (s, 2H, S-CH), 7.87 (d, J=16.2 Hz, 2H,trans-CH), 7.56 (d, J=16.2 Hz, 2H, trans-CH), 7.50 (t, J=7.4 Hz 2H,Ar-CH), 7.43 (t, J=7.4 Hz 2H, Ar-CH), 7.22 (d, J=8.2 Hz, 2H, Ar-CH), 7.03 (d, J=8.2 Hz, 2H, Ar-CH), 6.73 (s, 2H, Ar-CH), 4.07 (t,J=5.6 Hz 2H, OCH2), 3.41 (t, J=6.5 Hz, 2H, N3CH2), 1.9-1.8 (m, 4H,CH2CH2), 1.55 (s, 6H, Ar- CH3), ppm.13C NMR (126 MHz, CDCl3) deltaC159.5, 152.4,142.2, 140.5, 138.9, 137.4, 133.9, 133.7, 129.7, 127.3,127.2, 125.2, 124.8, 124.7, 122.9, 121.9, 120.3, 117.6, 114.9, 67.3,51.2, 26.5, 25.8, 14.9 ppm.

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Tanr?verdi Ecik, Esra; ?enkuytu, Elif; Okutan, Elif; Yenilmez Ciftci, Goenuel; Inorganica Chimica Acta; vol. 495; (2019);,
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1195-14-8, 2-Methylbenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of 9he, 9hh or 9hi (200 mmol) in dried THF (200 mL) held at -78 C in N2atmosphere was added dropwise 1.6 M n-BuLi in n-hexane (125 mL, 200 mmol) via syringe, and theresulting solution was stirred at -78 C for 1 h ( for 9he and 9hh) or returned to room temperaturefor 5 h (for 9hi) before dropwise addition of dried DMF (21.93 g, 300 mmol) via syringe. Thereafterthe reaction mixture was stirred at -78 C for 0.5 h and at room temperature for another 1 h. Thereaction mixture was poured into ice-water (600 mL) while stirring and the resulting mixture wasextracted with CH2Cl2 (300 mL ¡Á 3). The combined extracts were washed with 5% brine (500 mL),dried (Na2SO4) and evaporated on a rotary evaporator to give a residue, which was purified bycolumn chromatography to afford the pure product 10he, 10hh or 10hi.

1195-14-8, As the paragraph descriping shows that 1195-14-8 is playing an increasingly important role.

Reference£º
Article; Cai, Wenqing; Wu, Jingwei; Liu, Wei; Xie, Yafei; Liu, Yuqiang; Zhang, Shuo; Xu, Weiren; Tang, Lida; Wang, Jianwu; Zhao, Guilong; Molecules; vol. 23; 2; (2018);,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6314-28-9,Benzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.

6314-28-9, Benzo[Z>]thiophen-2-yl-carbamic acid tert-butyl ester (1-B).; A solution of compound 1-A (14.4 g, 80.6 mmol), N,N-diisopropylethylamine (15.5 mL, 88.6 mmol) and diphenylphosphoryl azide (20.8 mL, 96.7 mmol) in -butanol (150 mL) was heated at reflux for 8 h. The solvent was evaporated in vacuo, and the residue purified by flash column chromatography on silica gel, eluting with dichloromethane, to afford compound 1-B as a colorless solid (18.9 g, 94%). 1H-NMR (DMSO-^): delta 1.50 (s, 9H), 6.78 (s, IH), 7.16 (d of d, IH), 7.27 (d of d, IH), 7.58 (d, IH), 7.77 (d, IH), 10.70 (br s, IH); MS: m/z 250.2 (MH+).

6314-28-9 Benzo[b]thiophene-2-carboxylic acid 95864, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2009/12430; (2009); A1;,
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Benzothiophene | C8H6S – PubChem

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Thiosemicarbazide (1.82 g, 20.0 mmol) was added to a stirredsolution of benzo [b]thiophene-2-carboxaldehyde (1) (3.24 g,20.0 mmol) in absolute ethyl alcohol (40 ml) and then (1.0 ml) ofacetic acid was added. The reaction mixture was stirred underreflux for 20 h, cooled to room temperature and separate precipitatewas collected by filtration, washed with ethyl alcohol to affordthe desired product to yield 3.90 g (83%); mp 218-219 C, mp219-220 C [22]; eluent: dichloromethane/methanol (95:5),Rf 0.67.1H NMR (DMSO-d6) d(ppm): 7.35-7.43 (m, 2H, 2CHAr);7.59 (bs, 1H, NH2); 7.77 (s, 1H, CH); 7.81-7.86 (m, 1H, CHAr);7.91-7.96 (m, 1H, CH); 8.32 (bs, 1H, NH2); 8.37 (s, 1H, CH]N); 11.62(bs, 1H, NH). 13C NMR (DMSO-d6) d(ppm): 122.98 (C); 124.74 (C);125.28 (C); 126.44 (C); 128.16 (C); 138.27 (C); 139.63 (C); 139.78 (C);139.85 (C); 178.34 (C]S)., 3541-37-5

The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Rosada, Beata; Bekier, Adrian; Cytarska, Joanna; P?azi?ski, Wojciech; Zavyalova, Olga; Sikora, Adam; Dzitko, Katarzyna; ??czkowski, Krzysztof Z.; European Journal of Medicinal Chemistry; vol. 184; (2019);,
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1127-35-1, Benzo[b]thiophene-3(2H)-one 1,1-Dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

600 g of methanol, 36.4 g of compound Ia, 14.52 g of malononitrile, and 0.8 g of piperidine were successively added to a 1000 mL three-necked flask, and after stirring, stirring was started.The temperature was raised to 60 C, the reaction was kept for about 12 hours, and the reaction was stopped after the system was free of the compound Ia. The mixture was cooled to room temperature, suction filtered, and washed with methanol.The solid was dried to obtain 42.8 g of the compound Ib, and the yield was 93.0%.The purity is 96.3%. The HPLC data are shown in the table below, and the chromatogram is shown in Figure 2., 1127-35-1

As the paragraph descriping shows that 1127-35-1 is playing an increasingly important role.

Reference£º
Patent; Zhejiang Runtu Institute Co., Ltd.; Li Jianchang; Zhao Guosheng; Chen Baoxing; Tao Binbin; (15 pag.)CN109233323; (2019); A;,
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Benzothiophene | C8H6S – PubChem

5381-20-4,5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 62 2-(3-Benzo[b]thienyl)-2-trimethylsiloxyethanenitrile Benzo[b]thiophene-3-carbaldehyde [1.8 g., 11 mmoles, J. Chem. Soc. C., pp. 339-340 (1969)] and about 100 mg. of zinc iodide were combined in 35 ml. of ether. Trimethylsilylcarbonitrile (1.98 g., 20 mmoles) was added dropwise. After approximately 1 hour, the reaction mixture was washed in sequence with saturated sodium bicarbonate, water and brine, dried over anhydrous sodium sulfate, filtered and evaporated to yield 2-(3-benzo[b]thienyl)-2-trimethylsiloxyethanenitrile [2.5 g., oil, Rf 0.7 (1:2 ethyl acetate:hexane)].

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Inc.; US4332952; (1982); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

6314-28-9, Benzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6314-28-9, The compound 2-benzothiophenecarboxylic acid (0901-137) (1.0 g, 5.61 mmol, 1.0 equiv) was added to 20 ml of methanol,Then add concentrated sulfuric acid (0.1 g),The mixture was stirred at 60 C for 16 hours.After completion of the reaction, 50 ml of a saturated aqueous sodium hydrogencarbonate solution was added and the mixture was extracted with ethyl acetate. The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the target product 2-benzothiophenecarboxylic acid methyl ester (1.05). g, yield 97.4%) as a white solid

The synthetic route of 6314-28-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem