Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24434-84-2,Benzo[b]thiophene-3-carbonitrile,as a common compound, the synthetic route is as follows.

(a) Methyl(benzo[b]thiophen-3-yl)imidate hydrochloride Benzo[b]thiophen-3-carbonitrile (700 mg) was dissolved in dry methanol (25 ml), and the resulting solution cooled to 10 C. under a dry nitrogen atmosphere. Dry hydrogen chloride gas was passed through the chilled solution for 40 minutes, and the resulting red solution allowed to stand at room temperature overnight. Removal of solvent under reduced pressure and recrystallisation from methanol/ether afforded the title compound as white needles (810 mg), m.p. 197-200 C. deltaH (360 MHz, DMSO-d6) 4.35 (3H, s, OCH3), 7.53 (2H, m, H-5,6), 8.19 (2H, m, H-4, 7) 8.41 (1H, s, H-2); m/z 191(M+, 70%) 160(100), 133(30), 89(40).

24434-84-2, The synthetic route of 24434-84-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merck Sharp & Dohme Limited; US4940703; (1990); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of pyrrole-2-carbaldehyde 1a,b (2 mmol) in MeOH (3 mL) were added successively Na2SO4 (0.3 g), the appropriate amine 2ad (1.2 equiv), acid 3a (1.2 equiv), and isonitrile 4a,b (1.2 equiv) in a screw capped vial equipped with a magnetic stir bar. The reaction mixture was stirred at 50 C for 2448 h in a closed vial. After completion of the reaction (as indicated on TLC), the mixture was diluted with EtOAc (100 mL) and extracted with H2O (50 mL). The organic layer was washed with brine (50 mL), dried (MgSO4) and evaporated under reduced pressure to obtain a residue, which was subjected to silica gel column chromatography (50% EtOAc in heptane) to afford the desired products 5ad (Table 1)., 3541-37-5

As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Article; Kumar, Amit; Vachhani, Dipak D.; Modha, Sachin G.; Sharma, Sunil K.; Parmar, Virinder S.; Van Der Eycken, Erik V.; Synthesis; vol. 45; 18; (2013); p. 2571 – 2582;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

6314-28-9, Benzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EDC (0.178 g, 0.928 mmol), HOBt (0.128 g, 0.947 mmol), benzo(b)thiophene-2-carboxylic acid (0.151 g, 0.847 mmol), and triethylamine (0.42 ml_, 3.01 mmol) were added to a solution of the amine-HCI salt from Example 5g (0.436 g, 0.843 mmol) in CH2CI2 (9.0 mL). The reaction mixture was stirred at room temperature for 19 h before being diluted with CH2CI2 and washed with sat. NaHCO3, 1 N HCI, sat. NaHCO3, and brine. The organic layer was dried over Na2SO4, filtered, and concentrated. Column chromatography (10-100% ethyl acetate:hexane) yielded 0.433 g (80%) of the title compound as a white solid: 1H NMR (400 MHz, CDCI3-Cy) Y ppm 7.96 – 8.03 (m, 1 H) 7.83 – 7.91 (m, 2 H) 7.76 – 7.80 (m, 1 H) 7.53 – 7.59 (m, 1 H) 7.40 – 7.48 (m, 2 H) 7.38 (dd, J=8.59, 2.02 Hz, 1 H) 6.34 (d, J=7.07 Hz, 1 H) 6.02 (d, J=8.34 Hz, 1 H) 4.27 – 4.36 (m, 2 H) 3.65 – 3.70 (m, 1 H) 3.53 – 3.62 (m, 2 H) 3.33 – 3.45 (m, 3 H) 2.65 (d, J=10.11 Hz, 1 H) 2.39 – 2.50 (m, 3 H) 2.34 (d, J=7.83 Hz, 1 H) 2.17 (s, 1 H) 1.72 – 1.78 (m, 1 H) 1.64 – 1.71 (m, 1 H) 1.53 (ddd, J=13.96, 8.65, 5.68 Hz, 1 H) 1.43 (ddd, J=13.83, 8.65, 5.05 Hz, 1 H) 0.93 – 1.01 (m, 6 H); LCMS (m/z): 641.2/643.2 (M/M + 2f., 6314-28-9

6314-28-9 Benzo[b]thiophene-2-carboxylic acid 95864, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/70865; (2007); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

20532-33-6, 5-Chlorobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

20532-33-6, PREPARATION IX 3-Bromo-5-chlorobenzothiophene To a solution of 0.30 gm (1.77 mMol) 5-chlorobenzothiophene 1.0 mL acetic acid was added a solution of 0.31 gm (1.95 mMol) bromine in 1.0 mL acetic acid under a nitrogen atmosphere. The reaction was heated to 50 C. for 4 hours at which time the volatiles were removed under reduced pressure. The residue was partitioned between dichloromethane and aqueous sodium bicarbonate. The phases were separated and the organics were washed with saturated aqueous sodium chloride, dried over sodium sulfate and concentrated under reduced pressure to give 0.335 gm (76%) of the title compound as a tan solid. m.p.=85-86 C. MS(FD): m/e=249 (M+2) EA: Calculated for: C8 H4 BrClS: Theory: C, 38.82; H, 1.63. Found: C, 39.12; H, 1.72.

The synthetic route of 20532-33-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eli Lilly and Company; US5874427; (1999); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

17402-83-4, Benzo[b]thiophen-4-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 122 N-(benzo[b]thiophen-4-yl)-6-methylthiazolo[3,2-b][1,2,4]triazole-2-sulphonamide The product of Example 1 stage (c) (1.1 g) was added portionwise with stirring to 4-aminobenzo(b)thiophene (0.7 g) in dimethylaniline (4 ml.). The mixture was allowed to stand for 3 days prior to treatment with dilute hydrochloric acid and ether. The precipitated solid was isolated by filtration, washed with dilute hydrochloric acid, water and ether, and dried to give 1.4 g of crude product. This solid was treated with dilute ammonia solution, filtered, and the filtrate acidified. The precipitated product was filtered off, washed with water and ether, and dried to give 0.8 g of desired product, mp 205¡ã-209¡ã C., 17402-83-4

The synthetic route of 17402-83-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Schering Agrochemicals; US4795483; (1989); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

General procedure: Using a previously described method,23 a catalytic amount of anhydrous ZnI2 (3.2 mg, 20 mumol) and trimethylsilyl cyanide (119 mg, 1.2 mmol) was added to a stirred solution of one of the aldehydes 1a-d (1 mmol) in dry dichloromethane (10 mL) and the resulting mixture was stirred at room temperature until all of the aldehydes was transformed. The solvent was evaporated and the crude product was redissolved in 10 mL of methanol. The formed trimethylsilyl cyanohydrin decomposed when HCl (3 M, 5 mL) was added. The reaction mass was evaporated to the final volume of 5 mL, after which water (5 mL) and dichloromethane (10 mL) were added. After the separation of the two layers, the aqueous layer was extracted with dichloromethane (2 ¡Á 10 mL). The combined organic layers were dried over anhydrous Na2SO4 and the solvent was evaporated in vacuo.

As the paragraph descriping shows that 5381-20-4 is playing an increasingly important role.

Reference£º
Article; Naghi, Mara Ana; Bencze, Laszlo Csaba; Brem, Juergen; Paizs, Csaba; Irimie, Florin Dan; Toa, Monica Ioana; Tetrahedron Asymmetry; vol. 23; 2; (2012); p. 181 – 187;,
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Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, Thianaphthene-3-carboxaldehyde (1.62 g, 10.0 mmol) was dissolved in anhydrous ethanol (50 ml_). Sulfamide (4.0 g, 42 mmol) was added and the mixture was heated to reflux for 16 hours. The mixture was cooled to room temperature. Sodium borohydride (0.416 g, 11.0 mmol) was added and the mixture was stirred at room temperature for three hours. The reaction was diluted with water (50 ml) and extracted with chloroform (3 x 75 ml_). The extracts were concentrated and chromatographed (5% methanol in DCM) and the solvent evaporate to yield the title compound as a white solid. 1H NMR (DMSO-(J6): delta 7.98 (1 H, dd, J = 6.5, 2.3 Hz), 7.92 (1 H, dd, J =6.6, 2.4 Hz), 7.62 (1 H, s), 7.36-7.45 (2H, m), 7.08 (1 H, t, J = 6.3 Hz), 6.72 (2H, S)1 4.31 (2H, d, J = 6.3 Hz).

5381-20-4 Thianaphthene-3-carboxaldehyde 227328, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2007/98486; (2007); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

17402-83-4, Benzo[b]thiophen-4-amine is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[00348] To a stirred solution of benzo[b]thiophen-4-amine (1 g, 6.70 mmol) and pyridine (1.355 mL, 16.75 mmol) in (?(? (15 mL) was added dropwise methanesulfonyl chloride (0.574 mL, 7.37 mmol) at 0 ¡ãC under nitrogen atmosphere. The reaction mixture was then allowed to warm to room temperature while stirring overnight. The reaction mixture was washed with saturated sodium bicarbonate solution, water, brine and dried over sodium sulfate. Evaporation of the solvent furnished a crude residue, which was subjected to BIOTAGE? (100percent methylene chloride) to give the title compound as a white solid (1.2g, 79percent). LC/MS: Example 105A (at) 2.88 min (RT) (Condition H). MS (ES): m/z=226.0, [M+H]+. XH NMR (400 MHz, MeOD) delta ppm 7.77 (1 hr, d, J=7.81 Hz), 7.59 (2 hr, d, J=1.26 Hz), 7.25-7.42 (2 hr, m), 2.94 (3 hr, s).

17402-83-4, As the paragraph descriping shows that 17402-83-4 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; HUANG, Audris; VELAPARTHI, Upender; LIU, Peiying; WO2013/49263; (2013); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

5381-20-4, Thianaphthene-3-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5381-20-4, This is based on Journal of Heterocyclic Chemistry, 18(5), 967-72, 1981. NaH (1.3 g, 28 mmol) was added to a mixture of 3-carbaldehydebenzo[b]thiophene (4.27 g, 25 mmol), diethyl benzylphosphonate (5.76 g, 25 mmol) in 50 mL of 1,2-dimethoxyethane at 0 C. under N2 and stirred for 15 minutes at 0 C. and 3 h at room temperature. The reaction mixture was then poured into ice water and filtrated. The solid from the filtration was recrystallized from ethanol to yield 4.5 g of desired product was obtained as a yellow solid. Synthesis of benzo[b]naphtha[2,1-d]thiophene.

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Universal Display Corporation; US2011/266526; (2011); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

16587-47-6, 6-Methylbenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(i) 2,3-Dibromo-6-methylbenzo[b]thiophene Bromine (15.2 g.) was added dropwise over 5 minutes to a stirred solution of 6-methylbenzo[b]-thiophene (7.0 g.) in chloroform (70 ml.) at room temperature. The resulting solution was stirred at room temperature for 4 hours and then evaporated. The residue was crystallized from methanol to give 2,3-dibromo-6-methylbenzo[b]thiophene (12.4 g.), m.p. 67.5-68.5 C. Analysis %: Found: C, 35.09; H, 1.90. C9 H9 Br2 S Requires: C, 35.33; H, 1.98%., 16587-47-6

The synthetic route of 16587-47-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc.; US4410539; (1983); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem