Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.

5381-20-4, 1-Benzothiophene-3-carbaldehyde (4c) (164 mg, 1.00 mmol) in 1.0 ml of dry THF was initially introduced into a dry 25 ml Schlenk flask filled with argon and with a magnetic stirrer core and septum, and Zn(TMP)2.2LiCl.2MgCl2 dissolved in THF (1.5 ml, 0.37 M, 0.55 equivalent) was added dropwise at room temperature. After 40 min the metallization was complete (GC analysis of reaction samples to which a solution of I2 in THF had been added indicated a conversion of more than 98%). A solution of 4-EtO2CPh-I (331 mg, 1.2 equivalents), Pd(dba)2 (5 mol %) (dba=dibenzylideneacetone) and tri-ortho-furylphosphine (Tfp) (10 mol %) in dry THF (2.5 ml) was then slowly added. After 5 h the reaction was ended by addition of saturated NH4Cl solution (10 ml). The aqueous phase was extracted with ethyl acetate (5¡Á10 ml), dried over MgSO4 and concentrated under reduced pressure. The crude product was purified by filter column chromatography (silica gel; CH2Cl2/pentane 1:1); 5c (208 mg, 67%) was obtained as a yellow, crystalline solid.

The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ludwig Maximilians Universitat Munchen; US2010/160632; (2010); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

130-03-0, Benzo[b]thiophen-3(2H)-one is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 5 mL flame-dried microwave flask was added benzo[b]thiophen-3(2H)-one (0.24 mmol, 0.12 equiv) and 5-aryl-2-formylpyrrole (0.2 mmol, 0.1 equiv). The flask was capped with analuminume-PTFE crimp cap, sealed, and evacuated and backfilled with nitrogen three times. To the flask was then added anhydrous toluene (2 mL, 0.1M in aldehyde) and piperidine (10 mL, 0.1 mmol,0.5 equiv). The flask was transferred to a pre-warmed oil bath set to 111 C and stirred for 2 h. After 2 h the flask was removed from theoil bath and cooled to room temperature and then to 0 C in a water-ice bath. To the flask was added hexanes (5 mL) and the flask was allowed to sit for an addition 10-30 min. The mixture was the filtered, and the precipitate was then triturated with hexanes to until the filtrate ran clear to provide the pure product as a red, blue,or purple solid depending on the substrate., 130-03-0

The synthetic route of 130-03-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zweig, Joshua E.; Ko, Tongil A.; Huang, Junrou; Newhouse, Timothy R.; Tetrahedron; vol. 75; 34; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of appropriate piperazine base (i-vi, 1 mmol), aldehydes (1a-1d, 1 mmol) and around 1.1-1.3 mmol quantity of TMSCN was taken in 5-8 mL water. After stirring for a while, 10 mg Indium powder was added to the reaction mixture and the resulted reaction mass was allowed to stir at room temperature for 45 min-2.5 h. After the completion ofthe reaction as monitored by Thin Layer Chro-matography using toluene: acetone (8:2) or ethyl acetate: n-nexane (8:2) solvent system, after treatment with diethyl ether or ethyl acetate, solution was filtered and washed with water and brine followed by anhydrous sodium sulphate treatment to dry. The residue was purified by silica gel column chromatography (ethyl acetate: n-hexane) to afford compounds 2i-5vi.

3541-37-5, As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Article; Patel, Rahul V.; Patel, Jigar K.; Nile, Shivraj H.; Park, Se Won; Letters in drug design and discovery; vol. 10; 5; (2013); p. 462 – 470;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6314-28-9,Benzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: The heteroaryl acyl chlorides used in the synthesis of compounds 1b, 2b, 3b, 4b and 5b were commercially available. For compounds 6b, 7b, 8b, 9b and 10b, the chloride derivatives were prepared from the corresponding carboxylic acid (9.18 mmol) nd thionyl chloride (30 mL) with heating under reflux for 2 h. The thionyl chloride was removed in vacuo. The resulting acyl chloride was used without further purification., 6314-28-9

As the paragraph descriping shows that 6314-28-9 is playing an increasingly important role.

Reference£º
Article; Font, Maria; Lizarraga, Elena; Ibanez, Elena; Plano, Daniel; Sanmarti?, Carmen; Palop, Juan A.; European Journal of Medicinal Chemistry; vol. 66; (2013); p. 489 – 498;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of benzo [b] thiophene-2-carbaldehyde (1.0 g, 6.17 mmol) and carbon tetrabromide (3.1 g, 9.25 mmol) in methylene chloride (50 mL) was cooled to 0C. A solution of triphenylphosphine (4.86 g, 18.3 mmol) in methylene chloride (20 mL) was added dropwise. After 1/2 hour the solution was placed on a plug of silica gel and eluted with 20% ethyl acetate: hexane. Concentration of the eluent resulted in the isolation of 1.3 g (67%) of 2-(2, 2-Dibromo-vinvl)-benzorb1thiophene as a yellow oil, which was used as such in the next step

3541-37-5, 3541-37-5 Benzo[b]thiophene-2-carboxaldehyde 736500, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; WYETH; WO2005/37207; (2005); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

3541-37-5, Benzo[b]thiophene-2-carboxaldehyde is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of Mg turnings (15mmol) and iodine (two pieces) in dry diethyl ether (10mL) at room temperature equipped with a reflux condenser was added dropwise a mixture of allylbromide (11mmol) in anhydrous diethyl ether (5mL). The mixture was allowed to reflux for 30min. Then, the mixture was cooled down to 0C followed by dropwise addition of the corresponding aldehyde (benzofuran or benzothiophene) (10mmol) in dry diethylether (3mL). The resultant mixture was then stirred for 3h. The reaction mixture was hydrolyzed with saturated ammonium chloride solution (10mL) and then with 1M HCl (2mL). The resultant mixture was then extracted with diethyl ether (3¡Á30mL). The combined organic phase was washed with brine (20mL) and dried over MgSO4 and evaporated in vacuo. The crude products were purified by flash column chromatography with ethyl acetate/hexane mixture (1:5)., 3541-37-5

The synthetic route of 3541-37-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bueyuekadal?, Nalan Nuriye; Aslan, Nezir; Guemue?, Selcuk; Guemue?, Ay?eguel; Tetrahedron Asymmetry; vol. 27; 19; (2016); p. 954 – 959;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6314-28-9,Benzo[b]thiophene-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of phenylmethyl 4-L-leucyl-1-piperazinecarboxylate (1.0 g, 3.34 mmol) in CH2CI2 (13.5 ml_) was added EDC (571 mg, 2.98 mmol), HOOBt (8.8 mg, 0.054 mmol), i -benzothiophene-2-carboxylic acid (530mg, 2.98 mmol), and 4-methylmorpholine (1.5ml_, 13.5mmol). The reaction mixture was stirred at room temperature for 20 h whereupon the reaction was diluted with CH2CI2 and washed with 10% citric acid and brine. The organic layer was dried over Na2SO4, filtered, and concentrated. Column chromatography (10-80% ethyl acetate:hexane) afforded 1.3 g (88% yield) of the title compound as a white solid: LCMS (m/z): 494.2 (M+H)., 6314-28-9

As the paragraph descriping shows that 6314-28-9 is playing an increasingly important role.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/70865; (2007); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

16587-47-6, 6-Methylbenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 23 [0189] Preparation of (2S)-3-[4-(6-Methylbenzo[b]thiophen-2-yl)piperidinyl]-1-(1H-2-methylindol-4-yl)oxy-2-propanol oxalate. [CHEMMOL-00057] [0190] Preparation of N-t-Butoxycarbonyl-4-hydroxy-4-(6-methylbenzo[b]thiophen-2-yl)piperidine. [CHEMMOL-00058] [0191] Scheme IA, Step A: To a solution of 6-methylbenzo[b]thiophene (1.25 g, 8.43 mmol) in dry THF (20 mL) at -78 C. was added 1.6 M n-BuLi in hexanes (6.32 mL, 10.1 mmol). The solution was stirred at -78 C. for 40 min. 1-t-Butoxycarbonyl-4-piperidone (1.84 g, 9.27 mmol) dissolved in THF (10 mL) was added via a cannula at -78 C. The reaction mixture was stirred at -78 C. for 3 h. The reaction was then quenched with 50 mL of water. The mixture was extracted (3¡Á75 mL) with EtOAc. The combined organic layers were dried over MgSO4 and filtered. The filtrate was concentrated to an oil and allowed to stand 3 days in which time the material crystallized. The crystals were rinsed with a mixture of EtOAc/hexanes to give the intermediate title compound as yellow crystals (2.13 g, 72.6%). IR (KBr) 1681, 1429, 1246 cm-1. FD+MS 347.0 (M).

16587-47-6, 16587-47-6 6-Methylbenzo[b]thiophene 35790, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Hansen, Marvin Martin; He, John Xiaoqiang; Honigschmidt, Nicholas Allan; Koch, Daniel James; Kohn, Todd Jonathan; Rocco, Vincent Patrick; Spinazze, Patrick Gianpietro; Takeuchi, Kumiko; US2004/6229; (2004); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

154650-81-4, Benzo[b]thiophene-6-carbonitrile is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

K2C03 (40 mg, 0.292 mmol), Pd(OAc)2 (2.2 mg, 0.010 mmol), tricyclohexylphosphine (5.5 mg, 0.019 mmol), and pivalic acid (6 mg, 0.058 mmol) were placed in a microwave vial equipped with a magnetic stir bar. 6-Cyanobenzothiophene, INTERMEDIATE 13 (31 mg, 0.195 mmol) and l-bromo-4-(l-methylethyl)benzene (47 mg, 0.234 mmol) were added as well as DMF (0.6 ml). The sealed reaction vial was heated in a microwave reactor at 180 C for 30 min. Water and DCM were added and the organic layer evaporated. The crude product was purified by flash column chromatography using 5% EtOAc in n-heptane as eluent. Yield: 18 mg (33%); white solid. MS (ESI+) m z 278 [M+H]+. HPLC purity: 97%., 154650-81-4

As the paragraph descriping shows that 154650-81-4 is playing an increasingly important role.

Reference£º
Patent; KANCERA AB; HAMMER, Kristin; JOeNSSON, Mattias; KRUeGER, Lars; (230 pag.)WO2017/108282; (2017); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3541-37-5,Benzo[b]thiophene-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

the 0.162g (1 mmol) of benzothiophene-2-carbaldehyde and 0.119g (1mmol) of ethyl thiosemicarbazide placed in a 20ml of round bottom flask, then added 2-3ml of Absolute ethanol as a solvent, followed by the dropwise addition of 2-4 drops of glacial acetic acid, stirred at reflux for 10 mins at 80 C under shade. The reaction was Cool at room temperature, a white solid precipitated, suction filtered, recrystallized from ethanol to give a white product 1- (Benzothiophen-2- methylene) -4-ethyl- thiosemicarbazide, yield 84%, Melting point: 200.3-201.2 C. The white powder turned bright yellow after being irradiated with UV light at 365 nm. The bright yellow solid turned pale yellowish after visible light irradiation., 3541-37-5

As the paragraph descriping shows that 3541-37-5 is playing an increasingly important role.

Reference£º
Patent; Xinjiang University; Liu Lang; Qiao Yuqian; Jia Dianzeng; (8 pag.)CN107298674; (2017); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem