Tag: M.W:100-200

Application In Synthesis of Methyl 3-bromopropanoate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Methyl 3-bromopropanoate, is researched, Molecular C4H7BrO2, CAS is 3395-91-3, about Directed Nickel-Catalyzed Diastereoselective Reductive Difunctionalization of Alkenyl Amines. Author is Zhao, Lei; Meng, Xiao; Zou, Yifeng; Zhao, Junsong; Wang, Lili; Zhang, Lanlan; Wang, Chao.

We report herein an intermol. syn-arylalkylation and alkenylalkylation of alkenyl amines with two different organohalides (iodides and bromides) using Ni(II) catalyst. The cleavable bidentate quinolinamide was utilized after extensive directing group screening to enable olefin difunctionalization with high levels of regio-, chemo-, and diastereocontrol. This general and practical protocol was compatible with α- or β-substituted terminal alkenes and internal alkenes, providing rapid access to branched aliphatic amines bearing two skipped and vicinal stereocenters with high diastereoselectivities that would otherwise be difficult to synthesize.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Smart carbon dots as chemosensor for control of water contamination in organic media, published in 2021-01-15, which mentions a compound: 3395-91-3, mainly applied to carbon dot chemosensor water detection organic solvent, Name: Methyl 3-bromopropanoate.

A novel nanoprobe was synthesized by functionalizing gluthatione/citric acid-carbon dots (CDs) with a benzo-isoquinolin-based mol., Me 3-(4-(2-(5-((methylsulfonyl)oxy)pentyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)piperazin-1-yl)propanoate (water chemosensor, WCS), to detect trace amounts of water in non-aqueous media via on-off fluorescence. The design and synthesis of the free mol. WCS and the functionalized nanoprobe (CD-WCS) are described in detail and as well as their full characterization by different spectroscopic methods. WCS was found to be an excellent indicator of pH in aqueous media and exhibited, in solvents of different polarity, solvatochromic behavior. On the other hand, the modified fluorescence intensity of CD-WCS was found to be an excellent indicator for water in non-aqueous media (organic solvents and oil-based lubricants). In these media, CD-WCS showed weak fluorescence intensity due to a photoinduced electron transfer (PET) process. Sequential addition of trace amount of water led to revival of CD-WCS fluorescence intensity. The fluorescence on-off mechanisms are proposed for WCS in aqueous media as well as for CD-WCS in non-aqueous media. The anal. performance characteristics of CD-WCS showed a limit of detection for water of 0.00021% (volume/volume) in toluene and 0.00014% volume/volume in base-oil lubricant. The potential application of CD-WCS as chemosensor of water contamination in oil-based lubricants as well as green anti-wear/anti-friction lubricant additive are outlined.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

HPLC of Formula: 3395-91-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Methyl 3-bromopropanoate, is researched, Molecular C4H7BrO2, CAS is 3395-91-3, about Smart carbon dots as chemosensor for control of water contamination in organic media. Author is Espina-Casado, Jorge; Fernandez-Gonzalez, Alfonso; Diaz-Garcia, Marta E.; Badia-Laino, Rosana.

A novel nanoprobe was synthesized by functionalizing gluthatione/citric acid-carbon dots (CDs) with a benzo-isoquinolin-based mol., Me 3-(4-(2-(5-((methylsulfonyl)oxy)pentyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl)piperazin-1-yl)propanoate (water chemosensor, WCS), to detect trace amounts of water in non-aqueous media via on-off fluorescence. The design and synthesis of the free mol. WCS and the functionalized nanoprobe (CD-WCS) are described in detail and as well as their full characterization by different spectroscopic methods. WCS was found to be an excellent indicator of pH in aqueous media and exhibited, in solvents of different polarity, solvatochromic behavior. On the other hand, the modified fluorescence intensity of CD-WCS was found to be an excellent indicator for water in non-aqueous media (organic solvents and oil-based lubricants). In these media, CD-WCS showed weak fluorescence intensity due to a photoinduced electron transfer (PET) process. Sequential addition of trace amount of water led to revival of CD-WCS fluorescence intensity. The fluorescence on-off mechanisms are proposed for WCS in aqueous media as well as for CD-WCS in non-aqueous media. The anal. performance characteristics of CD-WCS showed a limit of detection for water of 0.00021% (volume/volume) in toluene and 0.00014% volume/volume in base-oil lubricant. The potential application of CD-WCS as chemosensor of water contamination in oil-based lubricants as well as green anti-wear/anti-friction lubricant additive are outlined.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Safety of Methyl 3-bromopropanoate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Methyl 3-bromopropanoate, is researched, Molecular C4H7BrO2, CAS is 3395-91-3, about Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL.

MyD88 gene mutation has been identified as one of the most prevalent driver mutations in the activated B-cell-like diffuse large B-cell lymphoma (ABC DLBCL). The published literature suggests that interleukin-1 receptor-associated kinase 1 (IRAK1) is an essential gene for ABC DLBCL harboring MyD88 mutation. Importantly, the scaffolding function of IRAK1, rather than its kinase activity, is required for tumor cell survival. Herein, we present our design, synthesis, and biol. evaluation of a novel series of potent and selective IRAK1 degraders. One of the most potent compounds, Degrader-3 (JNJ-1013) (I), effectively degraded cellular IRAK1 protein with a DC50 of 3 nM in HBL-1 cells. Furthermore, JNJ-1013 potently inhibited IRAK1 downstream signaling pathways and demonstrated strong anti-proliferative effects in ABC DLBCL cells with MyD88 mutation. This work suggests that IRAK1 degraders have the potential for treating cancers that are dependent on the IRAK1 scaffolding function.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Category: benzothiophene. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Methyl 3-bromopropanoate, is researched, Molecular C4H7BrO2, CAS is 3395-91-3, about Design, Synthesis, and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo. Author is Hao, Er-Jun; Li, Gong-Xin; Liang, Yu-Ru; Xie, Ming-Sheng; Wang, Dong-Chao; Jiang, Xiao-Han; Cheng, Jia-Yi; Shi, Zhi-Xian; Wang, Yang; Guo, Hai-Ming.

In the present work, 103 novel acyclic nucleosides were designed, synthesized, and evaluated for their anticancer activities in vitro and in vivo. The structure-activity relationship (SAR) studies revealed that most target compounds inhibited the growth of colon cancer cells in vitro, of which (chloro-9H-purinyl)dodecanol I exhibited the most potent effect against the HCT-116 and SW480 cells with IC50 values of 0.89 and 1.15μM, resp. Furthermore, all of the (R)-configured acyclic nucleoside derivatives displayed more potent anticancer activity compared to their (S)-counterparts. Mechanistic studies revealed that compound I triggered apoptosis in the cancer cell lines via depolarization of the mitochondrial membrane and effectively inhibited colony formation. Importantly, I inhibited the growth of the SW480 xenograft in a mouse model with low systemic toxicity. These results indicated that acyclic nucleoside compounds are viable as potent and effective anticancer agents, and I may serve as a promising lead compound that merits further attention in future anticancer drug discovery.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Mennie, Katrina M.; Vara, Brandon A.; Levi, Samuel M. researched the compound: Methyl 3-bromopropanoate( cas:3395-91-3 ).Related Products of 3395-91-3.They published the article 《Reductive sp3-sp2 Coupling Reactions Enable Late-Stage Modification of Pharmaceuticals》 about this compound( cas:3395-91-3 ) in Organic Letters. Keywords: chloroaminopyrimidine bromide alkyl halide chemoselective cross electrophile reductive coupling. We’ll tell you more about this compound (cas:3395-91-3).

Late-stage derivatization of pharmaceutically relevant scaffolds relies on the availability of highly functional-group tolerant reactions. Reactions that increase the sp3 character of mols. enable the pursuit of more selective and well-tolerated pharmaceuticals. Herein, we report the use of sp3-sp2 cross-electrophile reductive couplings to modify a generic ATP-competitive kinase inhibitor with a broad range of primary and secondary alkyl halide coupling partners.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Methyl 3-bromopropanoate(SMILESS: O=C(OC)CCBr,cas:3395-91-3) is researched.Related Products of 3395-91-3. The article 《A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery》 in relation to this compound, is published in Chemical Communications (Cambridge, United Kingdom). Let’s take a look at the latest research on this compound (cas:3395-91-3).

A novel bright near-IR II (NIR-II, 1000-1700 nm) fluorescent probe with excellent water-solubility, superior photostability, and excellent in vitro and in vivo biocompatibility was facilely synthesized for in vivo biomedical imaging of xenograft breast tumor and chem. induced spontaneous breast carcinoma. To the best of our knowledge, it is the first time that the superior practical applications of this NIR-II probe in dimethylbenzanthracene (DMBA)-induced rat mammary carcinoma imaging and image-guided rat carcinoma surgery were demonstrated.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Application In Synthesis of Methyl 3-bromopropanoate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Methyl 3-bromopropanoate, is researched, Molecular C4H7BrO2, CAS is 3395-91-3, about Efficient Synthesis and Bioevaluation of Novel Dual Tubulin/Histone Deacetylase 3 Inhibitors as Potential Anticancer Agents. Author is Peng, Xiaopeng; Chen, Jingxuan; Li, Ling; Sun, Zhiqiang; Liu, Jin; Ren, Yichang; Huang, Junli; Chen, Jianjun.

Novel dual HDAC3/tubulin inhibitors were designed and efficiently synthesized by combining the pharmacophores of SMART (tubulin inhibitor) and MS-275 (HDAC inhibitor), among which compound 15c was found to be the most potent and balanced HDAC3/tubulin dual inhibitor with high HDAC3 activity (IC50 = 30 nM) and selectivity (SI > 1000) as well as excellent antiproliferative potency against various cancer cell lines, including an HDAC-resistant gastric cancer cell line (YCC3/7) with IC50 values in the range of 30-144 nM. Compound 15c inhibited B16-F10 cancer cell migration and colony formation. In addition, 15c demonstrated significant in vivo antitumor efficacy in a B16-F10 melanoma tumor model with a better TGI (70.00%, 10 mg/kg) than that of the combination of MS-275 and SMART. Finally, 15c presented a safe cardiotoxicity profile and did not cause nephro-/hepatotoxicity. Collectively, this work shows that compound 15c represents a novel tubulin/HDAC3 dual-targeting agent deserving further investigation as a potential anticancer agent.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

HPLC of Formula: 3395-91-3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Methyl 3-bromopropanoate, is researched, Molecular C4H7BrO2, CAS is 3395-91-3, about A bright NIR-II fluorescent probe for breast carcinoma imaging and image-guided surgery. Author is Zeng, Xiaodong; Xie, Liru; Chen, Deliang; Li, Shanshan; Nong, Jinxia; Wang, Bo; Tang, Lin; Li, Qianqian; Li, Yang; Deng, Zixin; Hong, Xuechuan; Wu, Mingfu; Xiao, Yuling.

A novel bright near-IR II (NIR-II, 1000-1700 nm) fluorescent probe with excellent water-solubility, superior photostability, and excellent in vitro and in vivo biocompatibility was facilely synthesized for in vivo biomedical imaging of xenograft breast tumor and chem. induced spontaneous breast carcinoma. To the best of our knowledge, it is the first time that the superior practical applications of this NIR-II probe in dimethylbenzanthracene (DMBA)-induced rat mammary carcinoma imaging and image-guided rat carcinoma surgery were demonstrated.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Methyl 3-bromopropanoate, is researched, Molecular C4H7BrO2, CAS is 3395-91-3, about The Synthesis of a Two-Photon Fluorescence Labelling Probe and its Immunochromatographic Strip for Rapid Diagnosis of COVID-19, the main research direction is two photon fluorescence labeling probe immunochromatog strip COVID19 diagnosis.Electric Literature of C4H7BrO2.

A two-photon fluorescence labeling probe (LP) was synthesized, and LP-Ag was obtained by LP labeling the N-protein antigen (Ag) of COVID-19. LP-Ag was made into an immunochromatog. strip. When a blood sample was added to the sample hole of the test card, it would move forward along the nitrocellulose (NC) film. If the sample contained IgM, the IgM bound to LP-Ag and formed an M line with the coated mouse anti-human IgM antibody, giving a pos. response to the presence of IgM of COVID-19. The sensitivity, specificity, and accuracy of the immunochromatog. strip based on the LP was compared with those of the nucleic acid detection method and the colloidal gold method, proving it to be much simpler than the nucleic acid detection method, which can greatly shorten the detection period, and to be much more stable than the colloidal gold method, which can overcome uncertainty. LP-Ag can be used to image lung tissue with COVID-19 by two-photon fluorescence microscopy (TFM).

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem