Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4923-87-9,5-Bromobenzothiophene,as a common compound, the synthetic route is as follows.

General procedure: The appropriate Grignard reagent (1.3 equiv) generated according to GP 1 was added to ketone 15 (1.0 equiv) suspended in THF (2mL/mmol) and heated to 60C for 2h. At 25C the mixture was quenched with saturated aqueous NH4Cl solution and extracted with Et2O. The organic phases were dried over Na2SO4 and concentrated under reduced pressure. The crude product was purified by recrystallization or by column chromatography over silica gel.

4923-87-9, As the paragraph descriping shows that 4923-87-9 is playing an increasingly important role.

Reference£º
Article; Toth, Krisztian; Hoefner, Georg; Wanner, Klaus T.; Bioorganic and Medicinal Chemistry; vol. 26; 12; (2018); p. 3668 – 3687;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20699-85-8,Methyl 5-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

A mixture of 300 mg of methyl 5-aminobenzo[b]thiophene-2-carboxylate, 316 g of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, 275 mg of benzoic acid, 18 mg of N,N-dimethyl-4-aminopyridine, and 10 ml of tetrahydrofuranwas stirred for 24 hours at room temperature. The reaction mixture was concentrated under reducedpressure, and tert-butyl methyl ether was added to the residues. The organic layer was washed with 1 M aqueoushydrochloric acid solution, 1 M aqueous sodium hydrogen carbonate solution, and saturated saline, dried over magnesiumsulfate, and concentrated under reduced pressure, thereby obtaining 318 mg of methyl 5-(benzoylamino)benzo[b]thiophene-2-carboxylate., 20699-85-8

The synthetic route of 20699-85-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sumitomo Chemical Company Limited; MUKUMOTO, Fujio; TAMAKI, Hiroaki; KUSAKA, Shintaro; IWAKOSHI, Mitsuhiko; EP2926660; (2015); A1;,
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Benzothiophene | C8H6S – PubChem

4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-bromobenzothiophene (12, 11.5 g, 45.1 mmol) in toluene (150 mL) under argon was added palladium acetate (0.84 g, 3.75 mmol), P(iBuNCH2CH2)3N (2.6 g, 7.6 mmol), and sodium tert-butoxide (5.4 g, 56.3 mmol). The reaction mixture was stirred for 2 min at room temperature, and then 7-bromodihydroisoquinolinone (11, 9.0 g, 37.5 mmol) was added. The resultant solution was heated at 70 C for 30 min, and then it was cooled to room temperature. The reaction was quenched with aqueous ammonium chloride and extracted with dichloromethane. The organic extract was washed with brine, dried over sodium sulfate, and concentrated in vacuo. The residue obtained was purified by flash column chromatography (eluent: 80/20 dichloromethane/EtOAc) to give the desired 4-(5-benzothiophen-yl)dihydroisoquinolinone (13, 8.84 g, 63%) as a light yellow foam.

4923-87-9, The synthetic route of 4923-87-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hu, Min; Guzzo, Peter R.; Zha, Congxiang; Nacro, Kassoum; Yang, Yuh-Lin; Hassler, Carla; Liu, Shuang; Tetrahedron Letters; vol. 53; 7; (2012); p. 846 – 848;,
Benzothiophene – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.360575-29-7,Methyl 4-bromobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

12113] A mixture of 500 mg of methyl 4-bromobenzo[b] thiophene-2-carboxylate, 161 mg of methylboronic acid,g of potassium phosphate, 151 mg ofa [1,1?-bis(diphe- nylphosphino)ferrocene]palladium (II) dichloride dichloromethane adduct, 6 ml of 1,4-dioxane, and 0.1 ml of waterstirred for 3 hours at 100 C. under a nitrogen atmosphere. Afier being cooled to room temperature, the reaction mixture was concentrated under reduced pressure. Chloroform and water were added to the residues, and insoluble matter was separated by filtration. Tbe filtrate was extracted using chloroform, and the organic layer was washed with saturated saline, dried over magnesium sulfate, and then concentrated under reduced pressure. The residues were subjected to silica gel colunm chromatography, thereby obtaining 340 mg of methyl 4-methylbenzo[b]thiophene-2- carboxylate (hereinafier, described as a ?compound 22 ofpresent invention?).12114] Compound 22 of the Present InventionMe12115] ?H-NMR (CDC13) oe: 8.17-8.16 (m, 1H), 7.71-7.69(m, 1H), 7.37-7.35 (m, 1H), 7.20-7.18 (m, 1H), 3.95 (s, 3H),2.64 (s, 3H)., 360575-29-7

The synthetic route of 360575-29-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

20699-85-8, Methyl 5-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Production Example 4012240] A mixture of 300 mg of methyl 5-aminobenzo[b] thiophene-2-carboxylate, 310 g of 1 -ethyl-3-(3-dimethylami- nopropyl)carbodiimide hydrochloride, 294 mg of benzoic acid, 18.4 mg of N,N-dimethyl-4-aminopyridine, and 20 ml of tetrahydrofuran was stirred for 24 hours at room temperature. The reaction mixture was concentrated under reduced pressure, and tert-butyl methyl ether was added to the residues. The organic layer was washed with a 1 M aqueous hydrochloric acid solution, a 1 M aqueous sodium hydrogen carbonate solution, and saturated saline, dried over magnesium sulfate, and concentrated under reduced pressure, thereby obtaining 318 mg of methyl 5-benzoylaminobenzo [b]thiophene-2-carboxylate (hereinafier, described as a ?compound 68 of the present invention?). 12241] Compound 68 of the Present Invention12242] ?H-NMR (CDC13) oe: 8.40 (br s, 1H), 8.05 (s, 1H),7.91-7.90 (m, 3H), 7.86-7.84 (m, 1H), 7.58-7.53 (m, 4H),3.96 (s, 3H).

20699-85-8, The synthetic route of 20699-85-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20699-85-8,Methyl 5-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of compound IV of Scheme IV (500 mg, 2.42 mmol) in CH2CI2 (35 mL) was added slowly bromo-acetyl chloride (320 muL, 2.045 mmol) in CH2CI2 (15 mL) at rt. Then, DIEA (422 muL, 2.42 mmol) was added dropwise. The reaction mixture was left to stir at rt for 3 hours. Water was added, and the reaction mixture was extracted with CH2CI2, dried and solvent evaporated in vacuo to yield 5-(2-Bromo-acetylamino)- benzo[b]thiophene-2-carboxylic acid methyl ester (XIV) quantitatively.

20699-85-8, The synthetic route of 20699-85-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; S*BIO PTE LTD; WO2006/101454; (2006); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20699-86-9,Methyl 5-nitrobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

Preparation of Methyl 5-aminobenzo[b]thiophene-2-Carboxylate In a 250 ml round-bottomed flask fitted with a Teflon stirrer and a reflux condenser, methyl 5-nitrobenzo[b]thiophene-2-carboxylate (10 g, 42.18 mmole) was dissolved in ethanol (100 ml). Tin (II) chloride dihydrate (5 equivalents, 47.60 g, 211 mmole) was added in one lot and the resulting slurry was reluxed for 18 hours while being stirred. The reaction mixture was cooled to room temperature, transferred to a 2000 ml Erlenmeyer flask, and carefully quenched with 5% sodium bicarbonate solution (aprroximately 700 ml) until effervescense was no longer detected. The resulting precipitate was filtered off and air-dried. The dried solid was dissolved in hot ethanol (500 ml), and filtered to remove undissolved material. The filtrate was evaporated in vacuo to give 8.564 g (96%) of methyl 5-aminobenzo[b]thiophene-2-carboxylate.

20699-86-9, As the paragraph descriping shows that 20699-86-9 is playing an increasingly important role.

Reference£º
Patent; Geron Corporation; US5863936; (1999); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

35212-85-2, Methyl 3-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A. 3-Aminobenzothiophene (20A) To a solution of 3-amino-benzo[b]thiophene-2-carboxylic acid, methyl ester (1 g, 4.83 mmol, 1 eq) in 1-methyl-2-pyrrolidinone (8 mL) was added piperazine (2.08 g, 24.13 mmol, 5 eq). The reaction was stirred at 130 C. overnight. Ice was added, and the mixture was extracted with ethyl acetate. The organic extracts were washed twice with water, dried, and concentrated in vacuo. The crude material was purified by flash chromatography on silica gel eluding with 40% ethyl acetate in hexanes to provide 600 mg (83%) of Compound 20A as a yellow oil., 35212-85-2

The synthetic route of 35212-85-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Salvati, Mark E.; Balog, James Aaron; Shan, Weifang; Giese, Soren; US2003/114420; (2003); A1;; ; Patent; Salvati, Mark E.; Balog, James Aaron; Shan, Weifang; Giese, Soren; Harikrishnan, Lalgudi S.; US2004/77606; (2004); A1;,
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Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-32-9,6-Bromobenzothiophene,as a common compound, the synthetic route is as follows.

(b) Benzo[b]thiophene-6-carboxaldehyde. A mixture of 6-bromobenzo[b]thiophene [9.6 g; prepared according to Nippon Kagaku Zasshi, 88, 758 (1967): Chem. Abstr., 69, 59018q (1968)], magnesium (1.64 g), and 1,2-dibromoethane (4.23 g) in anhydrous diethyl ether (90 ml) was stirred and gently heated for 3 hr. N-formylpiperidine (5.09 g) in anhydrous diethyl ether (15 ml) was added to the cooled mixture which was subsequently allowed to stand for 12 hr. the mixture was poured into a dilute hydrochloric acid solution. the dried (MgSO4) ether extract was evaporated and the residue was purified by column chromatography over silica gel with chloroform/hexane (1:8 v/v) elution to give benzo[b]thiophene-6-carboxaldehyde as yellow oil. Pmr spectrum (CDCl3; delta in ppm): 7.36 (1H, d); 7.68 (1H, d); 7.84 (2H, s); 8.16 (1H, s); 10.04 (1H, s).

17347-32-9, 17347-32-9 6-Bromobenzothiophene 12744400, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; ICI Australia Limited; US4664693; (1987); A;,
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Benzothiophene | C8H6S – PubChem

20699-85-8, Methyl 5-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 3 (255 mg, 1.062 mmol) and compound 4 (200 mg, 0.965 mmol) were dissolved in DMF (3.22 mL). EDC (222 mg, 1.158 mmol) was added to the reaction mixture, followed by DMAP (118 mg, 0.965 mmol) and the reaction was stirred at rt overnight. The reaction mixture was diluted with EtOAc and was washed with sat’d NH4Cl, brine, dried over Na2S04, filtered and concentrated. The crude product was purified by silica gel chromatography (0% to 40% EtOAc/hexanes) to obtain compound 5 as an orange-white solid (300 mg, 0.699 mmol, 72% yield). LCMS = 6.014 min (8 min method). Mass observed (ESI+): 430.05 (M+H). 1H NMR (400 MHz, DMSO-i): d 1.46 (s, 9H), 3.83 (s, 3H), 3.89 (s, 3H), 6.97 (d, J = 8.8 Hz, 2H), 7.79 (d, J = 9.0 Hz, 1H), 7.97 (d, J = 8.9 Hz, 1H), 8.18 (s, 1H), 8.49 (s, 1H), 9.14 (s, 1H), 9.98 (s, 1H)., 20699-85-8

As the paragraph descriping shows that 20699-85-8 is playing an increasingly important role.

Reference£º
Patent; IMMUNOGEN, INC.; MILLER, Michael, Louis; SHIZUKA, Manami; CHARI, Ravi, V.J.; (312 pag.)WO2019/133652; (2019); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem