Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.89673-36-9,tert-Butyl benzo[b]thiophen-2-ylcarbamate,as a common compound, the synthetic route is as follows.

89673-36-9, C. Benzo[b]thiophen-2-ylamine hydrochloride (1e). Compound 1d (1.45 g, 5.81 mmol) was added to a solution of HCl in dioxane (4 N, 20 mL). The mixture was stirred at room temperature until all the starting material was consumed. The mixture was diluted with diethyl ether, and the product was collected by filtration and washed with diethyl ether to give an off white solid (0.89 g, 83%). 1H NMR (DMSO-d6): delta 6.43 (s, 1H), 6.8-7.2 (br s, 3H) superimposed on 7.05 (m, 1H) and 7.20 (m, 1H), 7.45 (d, 1H) and 7.66 (d, 1H); MS: m/z 150.1 (MH+).

As the paragraph descriping shows that 89673-36-9 is playing an increasingly important role.

Reference£º
Patent; Macielag, Mark J.; McNally, James J.; US2010/160289; (2010); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

360575-29-7, Methyl 4-bromobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 500 mg of methyl 4-bromobenzo[b]thiophene-2-carboxylate, 161 mg of methylboronic acid, 1.17g of potassium phosphate, 151 mg of a [1,1?-bis(diphenylphosphino)ferrocene]palladium (II) dichloride dichloromethaneadduct, and 6 ml of 1,4-dioxane, and 0.1 ml of water was stirred for 3 hours at 100C under a nitrogen atmosphere. Afterbeing cooled to room temperature, the reaction mixture was concentrated under reduced pressure. Chloroform andwater were added to the residues, and insoluble matter was separated by filtration. The filtrate was extracted usingchloroform, and the organic layer was washed with saturated saline, dried over magnesium sulfate, and then concentratedunder reduced pressure. The residues were subjected to silica gel column chromatography, thereby obtaining 340 mgof methyl 4-methylbenzo[b]thiophene-2-carboxylate., 360575-29-7

As the paragraph descriping shows that 360575-29-7 is playing an increasingly important role.

Reference£º
Patent; Sumitomo Chemical Company Limited; MUKUMOTO, Fujio; TAMAKI, Hiroaki; KUSAKA, Shintaro; IWAKOSHI, Mitsuhiko; EP2926660; (2015); A1;,
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Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

Preparation 11 1A: 3-(Benzo[b]thiophen-7-yl)-4-methylpyridine[00360] A vessel capable of sealing was charged with a mixture of 7- bromobenzo[b]thiophene (370 mg, 1.736 mmol), 4-methylpyridin-3-ylboronic acid HC1 (361 mg, 2.084 mmol), PdCl2(dppf)-CH2Ci2 adduct (70.9 mg, 0.087 mmol), dioxane (8 mL), and a 2.0 M aqueous solution of K3PO4 (3.47 mL, 6.95 mmol) and was purged with nitrogen for 10 min. The vessel was sealed and heated at 90 C for 10 hours. Upon cooling, the reaction mixture was diluted with CH2CI2 and filtered with CH2Cl2/MeOH washing. The filtrate was concentrated under reduced pressure. The residue was dissolved in CH2CI2 and washed with water, brine, dried over anhydrous Na2S04 and concentrated under reduced pressure. The crude material was purified by BIOTAGE eluting with 10%-40% EtOAc/CELC^ at 30 mL/min. Concentration of appropriate fractions provided the title compound (350 mg, 89% yield). LC/MS: Example 1 11A (at) 1.50 min (RT) (Condition G). MS (ES): m/z=226.12.1 [M+H]+. XH NMR (400 MHz, CDCI3) delta ppm 8.50-8.64 (2 hr, m), 7.89 (1 hr, dd, J=7.93, 1.13 Hz), 7.40-7.55 (3 hr, m), 7.25-7.33 (1 hr, m), 7.22 (1 hr, d, J=6.30 Hz), 2.21 (3 hr, s)., 1423-61-6

The synthetic route of 1423-61-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; HUANG, Audris; VELAPARTHI, Upender; LIU, Peiying; WO2013/49263; (2013); A1;,
Benzothiophene – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-32-9,6-Bromobenzothiophene,as a common compound, the synthetic route is as follows.

A mixture of compound B-198 (4.0 g, 0.019 mol) and cuprous cyanide (2.5 g, 28 mmol) in l-methylpyrrolidin-2-one (20 mL) was stirred at 200 C for 1 hour under microwave irradiation (150 W, 100 psi). On completion, the mixture was filtered, and the filtrate was diluted with dichloromethane (60 mL). This solution was washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuo to give crude compound B-199 (2.6 g, 87% yield) as a yellow solid. LCMS: (ES+) m/z (M+H)+ = 160.1, tR= 0.795.

17347-32-9, As the paragraph descriping shows that 17347-32-9 is playing an increasingly important role.

Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66371; (2015); A1;,
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Benzothiophene | C8H6S – PubChem

360576-01-8, Methyl 6-bromobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 1 (38.20 g, 151 mmol) was dissolved in toluene (300 mL), and benzyl mercaptan (24.50 g, 197.00 mmol),DIPEA (39.50g, 306.00mmol, 53.2mL),4,5-bis (diphenylphosphine) -9,9-dimethylxanthene(8.90 g, 15.40 mmol) and tris (dibenzylideneacetone) dipalladium (6.89 g, 7.53 mmol),The reaction was refluxed overnight.After the reaction, water (500 mL) was added, and ethyl acetate (300 mL) was extracted twice. The organic layers were combined, and the solvent was evaporated under reduced pressure.After purification by column chromatography (PE: EA = 100: 1)Compound 2 was obtained (27.00 g, 57% yield)., 360576-01-8

As the paragraph descriping shows that 360576-01-8 is playing an increasingly important role.

Reference£º
Patent; Chengdu Xiandao Pharmaceutical Development Co., Ltd.; Li Jin; Wang Wei; Chu Hongzhu; Lv Kaizhi; Liu Lichuan; Nong Yunhong; Chen Wei; (17 pag.)CN110229146; (2019); A;,
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4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The air in the flask was replaced with nitrogen. 5-bromobenzo [b] thiophene (10.44 g, 49.0 mmol) and Ni (dppp) Cl 2 (1.27 g, 2.33 mmol) were placed in the flask and 200 mL of diethyl ether was added.Thereafter, a 2.0 M solution of octyl magnesium bromide in diethyl ether (35.25 mL, 70.5 mmol) was slowly added dropwise, and the mixture was stirred at room temperature for 12 hours.Water was added to the obtained solution, and the mixture was extracted with hexane. The organic phase was dried by adding sodium sulfate.The hydrate of sodium sulfate was filtered, the filtrate was collected, and the solvent was distilled off from the filtrate using an evaporator.The obtained material was purified by column chromatography (silica gel, developing solvent: hexane) to obtain Compound 1 as a black liquid (yield = 10.0 g, 82.9%)., 4923-87-9

4923-87-9 5-Bromobenzothiophene 2776578, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; KYUSHU UNIVERSITY; KYOCERA CORPORATION; YASUDA, TAKUMA; MORI, TATSUYA; OHYAMA, TATSUYA; TAKEDA, KEIZO; (44 pag.)JP2017/210449; (2017); A;,
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Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.104795-85-9,Methyl 6-chlorobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of 600 mg (3.23 mmol) of 4-chloro-2-nitro-benzaldehyde in DMF (7 ml) were added 559 mg (4.04 mmol) of potassium carbonate and 294 mul (3.23 mmol) of methyl thioglycolate at 0 C. The reaction mixture was stirred for 30 min at 0 C. and then for 24 h at RT. Then the mixture was poured into ice-water and the precipitate was collected by filtration and dissolved in ethyl acetate. The solution was dried (MgSO4) and concentrated to yield 630 mg (86%) of 6-chloro-benzo[b]thiophene-2-carboxylic acid methyl ester as a white solid. 1HNMR (CDCl3, 300 MHz): delta 3.95 (s, 3H), 7.88 (dd, J=8.6 and 1.9 Hz, 1H), 7.79 (d, J=8.6 Hz, 1H), 7.85 (d, J=1.9 Hz, 1H), 8.02 (s, 1H).To a solution of 630 mg (2.78 mmol) of 6-chloro-benzo[b]thiophene-2-carboxylic acid methyl ester in THF (5 ml) were added 6.95 ml of 1N LiOH-solution and the reaction mixture was stirred at RT for 4 h. The pH was then adjusted to 2-3 by addition of 1N HCl and the mixture was extracted with ethyl acetate. The combined organic extracts were washed with brine, dried (MgSO4) and concentrated to yield 579 mg (98%) of 6-chloro-benzo[b]thiophene-2-carboxylic acid as white solid. MS (ISP) 211.0 (M-H)-.In analogy to example S3 (steps a to b) 139 mg (0.65 mmol) of 6-chloro-benzo[b]thiophen-2-carboxylic acid were converted into 52 mg (0.14 mmol) of (6-chloro-benzo[b]thiophen-2-ylmethyl)-[2-(3,4-dichloro-phenyl)-ethyl]-amine. The product was obtained as colorless liquid. MS (ISP) 370.0 (M+H)+.

104795-85-9, 104795-85-9 Methyl 6-chlorobenzo[b]thiophene-2-carboxylate 18526200, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Faeh, Christoph; Kuehne, Holger; Luebbers, Thomas; Mattei, Patrizio; Maugeais, Cyrille; Pflieger, Philippe; US2007/185113; (2007); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

360576-01-8, Methyl 6-bromobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 500 mg of methyl 6-bromobenzo[b]thiophene-2-carboxylate, 877 mg of tributyl vinyl tin, 213 mgof tetrakis(triphenylphosphine)palladium(0), and 4 ml of toluene was stirred for 5 hours at 110C under a nitrogenatmosphere. After the reaction mixture was cooled to room temperature, an aqueous saturated ammonium chloridesolution and ethyl acetate were added thereto, and insoluble matter was separated by filtration. Extraction was performedon the filtrate by using ethyl acetate, and the organic layer was washed with saturated saline, dried over magnesiumsulfate, and then concentrated under reduced pressure. The residues were subjected to silica gel column chromatography,thereby obtaining 229 mg of methyl 6-vinylbenzo[b]thiophene-2-carboxylate., 360576-01-8

360576-01-8 Methyl 6-bromobenzo[b]thiophene-2-carboxylate 22474078, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Sumitomo Chemical Company Limited; MUKUMOTO, Fujio; TAMAKI, Hiroaki; KUSAKA, Shintaro; IWAKOSHI, Mitsuhiko; EP2926660; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1423-61-6, 7-Bromobenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Combine 7-bromo-benzo[?]thiophene (6.53 g, 30.64 mmol), 5-fluoro-2- hydroxy phenyl boronic acid (4.87 g, 31.26 mmol), Pd(dppf)Cl2 (1.25 g, 1.53 mmol), 2-(di-tert-butylphosphino)biphenyl (0.28 g, 0.92 mmol), sodium carbonate (2 M, 30.64 mL, 61.92 mmol) in dioxane (60 mL, alternative THF) in a flask. Heat the mixture at 100 0C for 2 h. Dilute the mixture with chloroform/IPA (3/1). Wash the solution with aqueous saturated sodium chloride. Dry over sodium sulfate. Concentrate the solution in vacuo . Purify the residue by column chromatography (hexane to 10 % ethyl acetate in hexane) to give the title compound (6.0 g, 80 %) as a yellow solid. MS (ES) m/z 243 [M-I]+.

1423-61-6, The synthetic route of 1423-61-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2008/144223; (2008); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

146137-92-0, Methyl 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 1.00 g of methyl 5-trifluoromethyl- benzo[b]thiophene-2-carboxylate, 803mg of hydroxylamine hydrochloride, 276 mg of triethylamine, and 15 ml of methanol was stirred for 12 hours under reflux. The reaction mixture was concentrated under reduced pressure, and tert-butyl methyl ether was added to the residues. The organic layer was washed with 1 M hydrochloric acid and saturated saline, dried over magnesium sulfate, and then concentrated under reduced pressure. The residues were subjected to silica gel column chromatography, thereby obtaining 217mg of N-hydroxy-5-trifluoromethylbenzo[b]thiophene-2-carboxamide(hereinafier, described as a ?compound 160 of the present invention?). 12433] ?H-NMR (DMSO-D5) oe: 11.66 (br s, 1H), 9.37 (br s,1H), 8.39 (s, 1H), 8.29 (d, 1H, J=8.5 Hz), 8.06 (s, 1H), 7.75 (d,1H, J=8.5 Hz)., 146137-92-0

As the paragraph descriping shows that 146137-92-0 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem