Tag: M.W:200-300

351005-12-4, 5-Bromo-1,3-dihydrobenzo[c]thiophene 2,2-dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

16. Preparation of 2-(2 ,2-dioxo-2,3-dihydro-1 H-benzo[c]thiophen-5-yl)-4,4,5,5- tetramethyl-[1 ,3,2]dioxaborolane In a screw-capped vessel 5-bromo-1 3-dihydro-benzo[c]thiophene2,2-dioxide (100 mg, 0.40 mmol), bis(pinacolato)diboron (206 mg,0.81 mmol), potassium acetate (119 mg, 1.21 mmol) and Pd(dppf)C12.CH2CI2 (33.1 mg, 0.04 mmol) were suspended in THE SeccoSolv (5 mL).Nitrogen was bubbled through the mixture for 5mm. The reaction mixture was stirred at70C for 15 h. The mixture was diluted with THF (7 mL), filtered and the filtrate wasevaporated to dryness. The crude residue was purified by flash chromatography(heptane/DCM) to yield in 89.0 mg (75 %) of the title compound as an off-white solid.LC/MS (Method B): Rt = 2.53 mm, (M+Na) 317., 351005-12-4

As the paragraph descriping shows that 351005-12-4 is playing an increasingly important role.

Reference£º
Patent; MERCK PATENT GMBH; CANCER RESEARCH TECHNOLOGY LIMITED; SCHIEMANN, Kai; STIEBER, Frank; CALDERINI, Michel; BLAGG, Julian; MALLINGER, Aurelie; WAALBOER, Dennis; RINK, Christian; CRUMPLER, Simon Ross; (127 pag.)WO2015/144290; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

20699-85-8, Methyl 5-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

] A mixture of 500 mg of methyl 5-aminobenzo[b] thiophene-2-carboxylate, 323 mg of acetic anhydride, 623 mg of diisopropylethylamine, and 10 ml of dichloromethane was stirred for 4 hours at room temperature. The reaction mixture was washed with an aqueous saturated sodium hydrogen carbonate solution and saturated saline, dried over magnesium sulfate, and concentrated under reduced pressure. The residues were subjected to silica gel colunm chromatography, thereby obtaining 449 mg of methyl 5-(acetylamino) benzo[b]thiophene-2-carboxylate (hereinafier, described as a ?compound 67 of the present invention?).12238] Compound 67 of the Present InventionHj2239] ?H-NMR (CDC13) oe: 8.22-8.21 (m, 1H), 7.99 (s, 1H), 7.78-7.76 (m, 1H), 7.44-7.40 (m, 2H), 3.94 (s, 3H), 2.22 (s, 3H).

20699-85-8, Big data shows that 20699-85-8 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

A solution of commercially available 7-bromobenzo[b]thiophene (8.0 g, 37.5 mmol) in ether (50.0 mL) was cooled to -78 C was and treated dropwise with BuLi (1.6 M solution in Hexanes, 21 mL, 37.5 mmol) and stirred at -78 C for 20 min. The reaction mixture was treated with DMF (5.4 g, 67.4 mmol) and stirred at -78 C for 1 h. The reaction mixture was diluted with water and extracted with ether. The combined organic layer were washed with water, dried (MgSO4) filtered concentrated in vacuo and purified by chromatography (SiO2, EtOAc/Hexanes) to yield 5 as a colorless oil. 1H NMR (400 MHz, CDCl3) delta 10.25 (s, 1H), 8.12 (d, 1 H, J = 7.6 Hz), 7.90 (d, 1H, J = 7.2 Hz), 7.67 (d, 1H, J = 5.6 Hz), 7.59 (t, 1H, J = 7.6 Hz), 7.45 (d, 1H, J = 5.6 Hz)., 1423-61-6

The synthetic route of 1423-61-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Venkatraman, Srikanth; Velazquez, Francisco; Gavalas, Stephen; Wu, Wanli; Chen, Kevin X.; Nair, Anilkumar G.; Bennett, Frank; Huang, Yuhua; Pinto, Patrick; Jiang, Yueheng; Selyutin, Oleg; Vibulbhan, Bancha; Zeng, Qingbei; Lesburg, Charles; Duca, Jose; Huang, Hsueh-Cheng; Agrawal, Sony; Jiang, Chuan-Kui; Ferrari, Eric; Li, Cheng; Kozlowski, Joseph; Rosenblum, Stuart; Shih, Neng-Yang; Njoroge, F. George; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 2007 – 2017;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1423-61-6, 7-Bromobenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Combine 7-bromo-benzo[?]thiophene (6.53 g, 30.64 mmol), 5-fluoro-2- hydroxy phenyl boronic acid (4.87 g, 31.26 mmol), Pd(dppf)Cl2 (1.25 g, 1.53 mmol), 2-(di-tert-butylphosphino)biphenyl (0.28 g, 0.92 mmol), sodium carbonate (2 M, 30.64 mL, 61.92 mmol) in dioxane (60 mL, alternative THF) in a flask. Heat the mixture at 100 0C for 2 h. Dilute the mixture with chloroform/IPA (3/1). Wash the solution with aqueous saturated sodium chloride. Dry over sodium sulfate. Concentrate the solution in vacuo . Purify the residue by column chromatography (hexane to 10 % ethyl acetate in hexane) to give the title compound (6.0 g, 80 %) as a yellow solid. MS (ES) m/z 243 [M-I]+.

1423-61-6, The synthetic route of 1423-61-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2008/144223; (2008); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

146137-92-0, Methyl 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 1.00 g of methyl 5-trifluoromethyl- benzo[b]thiophene-2-carboxylate, 803mg of hydroxylamine hydrochloride, 276 mg of triethylamine, and 15 ml of methanol was stirred for 12 hours under reflux. The reaction mixture was concentrated under reduced pressure, and tert-butyl methyl ether was added to the residues. The organic layer was washed with 1 M hydrochloric acid and saturated saline, dried over magnesium sulfate, and then concentrated under reduced pressure. The residues were subjected to silica gel column chromatography, thereby obtaining 217mg of N-hydroxy-5-trifluoromethylbenzo[b]thiophene-2-carboxamide(hereinafier, described as a ?compound 160 of the present invention?). 12433] ?H-NMR (DMSO-D5) oe: 11.66 (br s, 1H), 9.37 (br s,1H), 8.39 (s, 1H), 8.29 (d, 1H, J=8.5 Hz), 8.06 (s, 1H), 7.75 (d,1H, J=8.5 Hz)., 146137-92-0

As the paragraph descriping shows that 146137-92-0 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

351005-12-4, 5-Bromo-1,3-dihydrobenzo[c]thiophene 2,2-dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

16. Preparation of 2-(2 ,2-dioxo-2,3-dihydro-1 H-benzo[c]thiophen-5-yl)-4,4,5,5- tetramethyl-[1 ,3,2]dioxaborolane In a screw-capped vessel 5-bromo-1 3-dihydro-benzo[c]thiophene2,2-dioxide (100 mg, 0.40 mmol), bis(pinacolato)diboron (206 mg,0.81 mmol), potassium acetate (119 mg, 1.21 mmol) and Pd(dppf)C12.CH2CI2 (33.1 mg, 0.04 mmol) were suspended in THE SeccoSolv (5 mL).Nitrogen was bubbled through the mixture for 5mm. The reaction mixture was stirred at70C for 15 h. The mixture was diluted with THF (7 mL), filtered and the filtrate wasevaporated to dryness. The crude residue was purified by flash chromatography(heptane/DCM) to yield in 89.0 mg (75 %) of the title compound as an off-white solid.LC/MS (Method B): Rt = 2.53 mm, (M+Na) 317., 351005-12-4

As the paragraph descriping shows that 351005-12-4 is playing an increasingly important role.

Reference£º
Patent; MERCK PATENT GMBH; CANCER RESEARCH TECHNOLOGY LIMITED; SCHIEMANN, Kai; STIEBER, Frank; CALDERINI, Michel; BLAGG, Julian; MALLINGER, Aurelie; WAALBOER, Dennis; RINK, Christian; CRUMPLER, Simon Ross; (127 pag.)WO2015/144290; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

20699-85-8, Methyl 5-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

] A mixture of 500 mg of methyl 5-aminobenzo[b] thiophene-2-carboxylate, 323 mg of acetic anhydride, 623 mg of diisopropylethylamine, and 10 ml of dichloromethane was stirred for 4 hours at room temperature. The reaction mixture was washed with an aqueous saturated sodium hydrogen carbonate solution and saturated saline, dried over magnesium sulfate, and concentrated under reduced pressure. The residues were subjected to silica gel colunm chromatography, thereby obtaining 449 mg of methyl 5-(acetylamino) benzo[b]thiophene-2-carboxylate (hereinafier, described as a ?compound 67 of the present invention?).12238] Compound 67 of the Present InventionHj2239] ?H-NMR (CDC13) oe: 8.22-8.21 (m, 1H), 7.99 (s, 1H), 7.78-7.76 (m, 1H), 7.44-7.40 (m, 2H), 3.94 (s, 3H), 2.22 (s, 3H).

20699-85-8, Big data shows that 20699-85-8 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Mukumoto, Fujio; Tamaki, Hiroaki; Kusaka, Shintaro; Iwakoshi, Mitsuhiko; US2015/282482; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

A solution of commercially available 7-bromobenzo[b]thiophene (8.0 g, 37.5 mmol) in ether (50.0 mL) was cooled to -78 C was and treated dropwise with BuLi (1.6 M solution in Hexanes, 21 mL, 37.5 mmol) and stirred at -78 C for 20 min. The reaction mixture was treated with DMF (5.4 g, 67.4 mmol) and stirred at -78 C for 1 h. The reaction mixture was diluted with water and extracted with ether. The combined organic layer were washed with water, dried (MgSO4) filtered concentrated in vacuo and purified by chromatography (SiO2, EtOAc/Hexanes) to yield 5 as a colorless oil. 1H NMR (400 MHz, CDCl3) delta 10.25 (s, 1H), 8.12 (d, 1 H, J = 7.6 Hz), 7.90 (d, 1H, J = 7.2 Hz), 7.67 (d, 1H, J = 5.6 Hz), 7.59 (t, 1H, J = 7.6 Hz), 7.45 (d, 1H, J = 5.6 Hz)., 1423-61-6

The synthetic route of 1423-61-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Venkatraman, Srikanth; Velazquez, Francisco; Gavalas, Stephen; Wu, Wanli; Chen, Kevin X.; Nair, Anilkumar G.; Bennett, Frank; Huang, Yuhua; Pinto, Patrick; Jiang, Yueheng; Selyutin, Oleg; Vibulbhan, Bancha; Zeng, Qingbei; Lesburg, Charles; Duca, Jose; Huang, Hsueh-Cheng; Agrawal, Sony; Jiang, Chuan-Kui; Ferrari, Eric; Li, Cheng; Kozlowski, Joseph; Rosenblum, Stuart; Shih, Neng-Yang; Njoroge, F. George; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 2007 – 2017;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

4923-87-9,4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

n-Butyl lithium (0.64ml, 1.2 mmol) was added drop wise to a solution of diisopropyl amine (0.25 mL, 1.5 mmol) in dry THF at -78C under nitrogen atmosphere over a period of 5 minutes. The reaction mixture was stirred at -20C for 30 minutes. To this was added 5-bromo-benzo[b]thiophene (200mg, 0.938 mmol) in dry THF at -78C, continued stirring for a further 30 minutes at -78C, followed by the addition of N-chlorosuccinamide (225mg, 1.68mmol) in dry THF at -78C. The resulting mixture was stirred at room temperature for 2 hours. The reaction was monitored by TLC (100% hexane). The reaction mixture was partitioned between ethyl acetate and saturated ammonium chloride. The organic layer was dried over sodium sulfate and concentrated to afford the crude product. Purification by column chromatography on silica gel (100% hexane) afforded 70mg of the product (30%> yield).1H NMR (CDC13, 300 MHz): 87.815-7.811 (d, IH), 7.57-7.55 (d, IH), 7.44- 7.41 (dd, IH), 7.12 (s, IH).

The synthetic route of 4923-87-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; BOCK, Mark Gary; GAUL, Christoph; GUMMADI, Venkateshwar Rao; SENGUPTA, Saumitra; WO2012/149413; (2012); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4923-87-9,5-Bromobenzothiophene,as a common compound, the synthetic route is as follows.

3-Hydroxy-5-[(l>S)-2-methoxy-(l-methylethyl)oxy]-N-(l-methyl-lH-pyrazol-3- yl)benzamide (610 mg, 2.0 mmol), 5-bromobenzothiophene (639 mg, 3.0 mmol), copper bis(triphenylphosphine) bromide (372 mg, 0.40 mmol) and caesium carbonate (1.95g, 6.0 mmol) in acetonitrile (7.5 mL) were heated at 160C for 15 hours. The mixture was concentrated in vacuo and re-dissolved in DCM (50 mL). The organics were washed with water (25 mL), brine (25 mL), dried (MgSO4) and concentrated in vacuo. The residue was twice chromatographed on silica, eluting with 0-3% methanol in DCM, to give the desired material as a grey gum (178 mg). m/z 438 (M+Eta)+

4923-87-9, 4923-87-9 5-Bromobenzothiophene 2776578, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/125972; (2006); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem