Tag: M.W:200-300

20699-85-8, Methyl 5-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-amino- benzo[b]thiophene-2-carboxylic acid methyl ester (989 mg, 4.79 mmol) in CH2CWTHF (5/5 mL) was added NMM (630 muL, 5.73 mmol) and chloroacetylchloride (415 muL, 5.25 mmol). After stirring 2.5 h, the mixture was diluted with EtOAc and H2O, and the solid was filtered yielding a pale-white solid, which was used without exp (MH+) 284.

20699-85-8, The synthetic route of 20699-85-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK & CO., INC.; ATON PHARMA, INC.; WO2006/115845; (2006); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

360576-01-8, Methyl 6-bromobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of compound B-110 (2.7 g, 10 mmol) and cyclopropylboronic acid (0.73 g, 10 mmol) in anhydrous toluene (50 mL) under N2 was added tetrakis(triphenylphosphine)palladium(0) (0.54 g, 0.47 mmol), followed by a solution of potassium phosphate (3.2 g, 15 mmol) in water (5 mL). The solution was stirred at room temperature for 0.5 hour before being heated to reflux for 7 hours. On completion, the mixture was cooled to room temperature and filtered. The filtrate was concentrated and purified by silica gel chromatography [petroleum ether: ethyl acetate = 60: 1] to give compound B-lll (1.8 g, 70% yield) as a white solid. LCMS: (ES+) m/z (M+H)+ = 233.0., 360576-01-8

360576-01-8 Methyl 6-bromobenzo[b]thiophene-2-carboxylate 22474078, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; KOENIG, Gerhard; MCRINER, Andrew, J.; (400 pag.)WO2016/100184; (2016); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.,1423-61-6

Under Ar atmosphere, to a mixture of 7-bromo-benzo[b]thiophene (40 g, 0.19 mol) and Zn(CN)2 (16 g, 0.132 mol) were added Pd(PPh3)4 (10 g) and DMF (800 mL) and the mixture was stirred at 90 0C -100 0C for 3 h. The reaction solution was cooled to room temperature (30 0C) and filtered. The filtrate was concentrated under reduced pressure. The residue was taken up with EtOAc (1000 mL) and saturated aq. NaHCO3 (500 mL) and then filtered. The filtrate layers were separated. The organic layer was washed with brine, dried over Na2SO4 and concentrated to give a crude product, which was purified by column chromatography (silica, elute; PE to EtOAc_PE=l:30) to afford the title compound (24 g, 80 %) as a white solid.

As the paragraph descriping shows that 1423-61-6 is playing an increasingly important role.

Reference£º
Patent; TARGEGEN INC.; WO2009/49028; (2009); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4923-87-9,5-Bromobenzothiophene,as a common compound, the synthetic route is as follows.,4923-87-9

General procedure: A 10-mL Schlenk tube was charged with Pd(OAc)2 (1.7 mg, 0.0075 mmol, 3.0 mol %), SPhos (6.2 mg, 0.015 mmol, 6.0 mol %), Na2CO3 (53.0 mg, 0.50 mmol, 2.0 equiv), potassium 6-fluoropyridine-2-trifluoroborate (101.5 mg, 0.50 mmol, 2.0 equiv) and heteroaryl halides (0.25 mmol, 1.0 equiv), followed by the addition of ethanol (2.0 ml). The reaction was carried out at 85 C for 16 h under the protection of nitrogen gas. Then, the reaction mixture was allowed to cool down to room temperature and the reaction solution was filtered through a thin pad of silica gel (eluting with ethyl acetate) and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel flash chromatography to produce the desired products (ethyl acetate/hexane=1:2-1:80).

4923-87-9 5-Bromobenzothiophene 2776578, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Ren, Wei; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng; Tetrahedron; vol. 68; 5; (2012); p. 1351 – 1358;,
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Benzothiophene | C8H6S – PubChem

4923-87-9,4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A: To a solution of isoquinoline-4-boronic acid (378 mg, 2.013 mmol) and 5-bromobenzothiophene (286 mg, 1.342 mmol) in dichloroethane (8 mL), sodium carbonate (2 M aqueous, 2 mL, 4 mmol) was added and the solution degassed by alternately evacuating and releasing to argon three times. To this heterogenic mixture was added palladium tetrakistriphenylphosphine (76 mg, 0.6711 mmol), the reaction mixture was degassed 3 times and heated to 90 C. with agitation for 12 hours. To this mixture was added EtOAc (100 mL), the mixture washed with water (3¡Á100 mL), and dried over anhydrous sodium sulfate. Purification by column chromatography (SiO2, 30 g, 50% ethyl acetate/hexane) provided the product as a white solid (316 mg): 1H NMR (CDCl3, 300 MHz) delta 9.29 (s, 1H), 8.55 (s, 1H), 8.06-7.97 (m, 4H), 7.68-7.65 (m, 2H), 7.56-7.42 (m, 3H). ESI-MS calc. for C17H11NS [M+H]+ 262. Found 262.

As the paragraph descriping shows that 4923-87-9 is playing an increasingly important role.

Reference£º
Patent; Molino, Bruce F.; Liu, Shuang; Guzzo, Peter R.; Beck, James P.; US2006/52378; (2006); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1423-61-6, 7-Bromobenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Scheme I, step C: To magnesium turnings (703 mg, 0.0289 mole) in 10 mL anhydrous tetrahydrofuran was added part of a solution of of 7-bromobenzothiophene (6.16 g, 0.0289 mole) in 30 mL anhydrous tetrahydrofuran. The mixture was brought to reflux and when the grignard reaction started, foaming was controlled by removing the heating mantle. The balance of the benzothiophene solution was added at a rate to maintain gentle reflux and then refluxed an additional hour. The reaction was cooled to 25 C. and of N-boc-3-pyrrolidone (5.34 g, 0.0289 mole) in 20 mL anhydrous tetrahydrofuran was added. The reaction was refluxed 1 hr and then stirred at room temperature overnight. The reaction was cooled in an ice bath and add dropwise saturated ammonium chloride solution until a granular precipitate was formed. The precipitate was filtered and rinsed with additional tetrahydrofuran. Evaporation gave 9.9 g of crude material as an oil which was flashed chromatographed over silica gel. Elution with 20% ethyl acetate in hexane provided the title compound (1.004 g, 11%) as a white foam. Mass Spec ESI+, M+1=320.2 (MW=319.4) 1H NMR (300 MHz, CDCl3) delta 1.48 (9H, s); 2.17 to 2.23 (3H, m); 3.71 to 3.94 (4H, m); 7.33 to 7.81 (5H, m).

1423-61-6, As the paragraph descriping shows that 1423-61-6 is playing an increasingly important role.

Reference£º
Patent; Eli Lilly and Company; US6353008; (2002); B1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

26018-73-5, 6-Chlorobenzo[b]thiophene-2-carboxylic acid is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[000924] Compound 242C (420 mg, 1.98 mmol) and copper powder (63 mg, 0.99 mmol) were suspended in quinoline (10 mL) and the resulting mixture was heated at 185 C for 2 h. After cooling down to room temperature, ethyl acetate (25 mL) was added and the suspension was filtered. The filtered cake was washed with ethyl acetate (5 mL x 2) and the combined organic layers were washed with aqueous HC1 solution (2 N, 10 mL x 2). After drying over anhydrous sodium sulfate, the solution was filtered and evaporated in vacuo to give a residue. The crude product was purified with flash column chromatography on silica gel (ethyl acetate in petroleum ether, from 0% to 10% v/v) to afford Compound 242D.

26018-73-5, The synthetic route of 26018-73-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel; BRIDGES, Alexander, James; WO2015/42397; (2015); A1;,
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Benzothiophene | C8H6S – PubChem

17347-32-9, 6-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

b) Benzo[b]thiophene-6-carboxaldehyde A mixture of 6-bromobenzo[b]thiophene [9.6 g; prepared according to Nippon Kagaku Zasshi, 88 , 758 (1967): Chem. Abstr., 69 , 59018q (1968)], magnesium (1.64 g), and 1,2-dibromoethane (4.23 g) in anhydrous diethyl ether (90 ml) was stirred and gently heated for 3 hr. N-formylpiperidine (5.09 g) in anhydrous diethyl ether (15 ml) was added to the cooled mixture which was subsequently allowed to stand for 12 hr. the mixture was poured into a dilute hydrochloric acid solution. the dried (MgSO4) ether extract was evaporated and the residue was purified by column chromatography over silica gel with chloroform/hexane (1:8 v/v) elution to give benzo[b]thiophene-6-carboxaldehyde as yellow oil. Pmr spectrum (CDCl3; delta in ppm): 7.36 (1H,d); 7.68 (1H,d); 7.84 (2H,s); 8.16 (1H,s); 10.04 (1H,s).

17347-32-9, As the paragraph descriping shows that 17347-32-9 is playing an increasingly important role.

Reference£º
Patent; ICI AUSTRALIA LIMITED; EP125059; (1991); B1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 40(3R)-N-[(2Z)-3-(1-benzothien-5-yl)-5-(hydroxymethyl)-1,3-thiazol-2(3H)-ylidene]-3-fluoropyrrolidine-1-carboxamide; Example 36B (74 mg, 0.30 mmol), 5-bromobenzo[b]thiophene (77 mg, 0.36 mmol), copper (I) iodide (12 mg, 0.06 mmol), and cesium carbonate (147 mg, 0.45 mmol) were added to a reaction vial with a septum-containing cap, and flushed with nitrogen three times. Then ethyl 2-oxocyclohexanecarboxylate (19.5 muL, 0.12 mmol) and anhydrous dimethyl sulfoxide (0.30 mL) were added through the septum, the mixture was stirred 30 minutes at room temperature, and then heated at 95 C. in the dark for 19 hours. Then the mixture was quenched with concentrated aqueous ammonium hydroxide (0.60 mL), passed through diatomaceous earth with an ethyl acetate rinse, concentrated, and purified by reverse phase HPLC using an acetonitrile/water 10 mM ammonium acetate method to give the title compound.1H NMR (300 MHz, d4-MeOH) delta ppm 1.85-2.25 (2H), 3.3-3.8 (4H), 4.61 (2H), 5.0-5.35 (1H), 7.26 (1H), 7.46 (1H), 7.51-7.56 (1H), 7.71 (1H), 7.99-8.06 (2H); MS (ESI) m/z 378 (M+H)+.

4923-87-9, 4923-87-9 5-Bromobenzothiophene 2776578, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; ABBOTT LABORATORIES; US2009/163470; (2009); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

34761-09-6, Ethyl 3-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of ethyl 3-amino-benzo[b]thiophene-2-carboxylate (8) (0.50 g, 2.3 mmol) in acetic acid (6 mL), was cooled in an ice bath to -5 C. Then, a solution of sodium nitrite (0.32 g, 4.6 mmol), in water (2 mL), was slowly added, under vigorous stirring. After 30 min, sodium azide (0.60 g, 9.2 mmol) in water (2 mL), was added over 10 min. The reaction mixture was stirred for further 3 h at room temperature and then slowly poured onto water/ice. The precipitate was collected by filtration to give 5, 0.40 g. Yield 70%. Mp 100 C (dec). IR: 2130 (N3), 1689 (CO) cm-1. 1H NMR delta: 1.30 (t, J = 7.1 Hz, 3H), 4.33 (q, J = 7.1 Hz, 2H), 7.34-7.51 (m, 2H), 7.88 (d, J = 8.1 Hz, 1H), 8.14 (d, J = 7.7 Hz, 1H). 13C NMR delta: 14.4 (q), 59.7 (t), 122.9 (d), 123.0 (d), 123.8 (d), 128.4 (d), 131.5 (s), 133.7 (s), 138.8 (s), 149.7 (s), 164.5 (s). Elem. Anal. calcd. for C11H9N3O2S: C, 53.43; H, 3.67; N, 16.99; found: C, 53.62; H, 3.55; N, 17.30.

34761-09-6, 34761-09-6 Ethyl 3-aminobenzo[b]thiophene-2-carboxylate 731510, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Lauria, Antonino; Abbate, Ilenia; Patella, Chiara; Martorana, Annamaria; Dattolo, Gaetano; Almerico, Anna Maria; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 416 – 424;,
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Benzothiophene | C8H6S – PubChem