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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5-Amino-1-(2-bromophenyl)-1H-pyrazole-4-carbonitrile, is researched, Molecular C10H7BrN4, CAS is 71856-54-7, about Synthesis and adenosine receptor affinity of a series of pyrazolo[3,4-d]pyrimidine analogs of 1-methylisoguanosine, the main research direction is methylisoguanosine analog pyrazolopyrimidine; aminoalkylarylpyrazolopyrimidinone preparation adenosine receptor affinity.Name: 5-Amino-1-(2-bromophenyl)-1H-pyrazole-4-carbonitrile.

Two series of pyrazolo[3,4-d]pyrimidine analogs I (R = Ph, substituted Ph; R1 = Me; R = Ph, R1 = Et, Pr, Bu, Ph; R = 3-ClC6H4, R1 = Et, Pr, Bu) of 1-methylisoguanosine have been synthesized. All I were tested for A1 adenosine receptor affinity by using a (R)-{3H}-N6-(phenylisopropyl)adenosine binding assay. The 3-chlorophenyl group showed the greatest activity in the N1-position and the Bu group produced the greatest activity in the N5-position. Combination of the best substituent in each of these positions enhanced the overall activity. The most potent compound was I (R = 3-C6H4Cl, R1 = Bu) (II) with an IC50 of 6.4 × 10-6M. Selectivity at the receptor subclasses was examined by performing an A2 adenosine receptor affinity assay with [3H]CGS 21680. This series of compounds were slightly less potent at A2 receptors. II was the most potent compound with an IC50 of 19.2 × 10-6M.

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Benzothiophene – Wikipedia,
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Recommanded Product: 254905-58-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate, is researched, Molecular C13H24N2O3, CAS is 254905-58-3, about Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen. Author is Mallinger, Aurelie; Crumpler, Simon; Pichowicz, Mark; Waalboer, Dennis; Stubbs, Mark; Adeniji-Popoola, Olajumoke; Wood, Bozena; Smith, Elizabeth; Thai, Ching; Henley, Alan T.; Georgi, Katrin; Court, William; Hobbs, Steve; Box, Gary; Ortiz-Ruiz, Maria-Jesus; Valenti, Melanie; De Haven Brandon, Alexis; Te Poele, Robert; Leuthner, Birgitta; Workman, Paul; Aherne, Wynne; Poeschke, Oliver; Dale, Trevor; Wienke, Dirk; Esdar, Christina; Rohdich, Felix; Raynaud, Florence; Clarke, Paul A.; Eccles, Suzanne A.; Stieber, Frank; Schiemann, Kai; Blagg, Julian.

WNT signaling is frequently deregulated in malignancy, particularly in colon cancer, and plays a key role in the generation and maintenance of cancer stem cells. The authors report the discovery and optimization of a 3,4,5-trisubstituted pyridine, 1-(3,5-Dichloropyridin-4-yl)piperidine-4-carboxamide (9), using a high-throughput cell-based reporter assay of WNT pathway activity. The authors demonstrate a twisted conformation about the pyridine-piperidine bond of (9) by small-mol. x-ray crystallog. Medicinal chem. optimization to maintain this twisted conformation, cognisant of physicochem. properties likely to maintain good cell permeability, led to 8-[3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4,5]decan-1-one (74) (CCT251545), a potent small-mol. inhibitor of WNT signaling with good oral pharmacokinetics. The authors demonstrate inhibition of WNT pathway activity in a solid human tumor xenograft model with evidence for tumor growth inhibition following oral dosing. This work provides a successful example of hypothesis-driven medicinal chem. optimization from a singleton hit against a cell-based pathway assay without knowledge of the biochem. target.

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Benzothiophene – Wikipedia,
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Category: benzothiophene. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate, is researched, Molecular C13H24N2O3, CAS is 254905-58-3, about The influence of conformational restriction in the C-terminus of growth hormone secretagogues on their potency.

In order to obtain more potent growth hormone secretagogues, a comparison of ipamorelin and NN703 suggested the addition of a polar group at the C-terminus of NN703. A study was conducted using constrained amines for this purpose. Here, substituted 4-piperidinylamino- and 4-dimethylaminopiperidino-substituents were found to give the most active compounds A replacement of the 4-dimethylaminopiperidino-substituent with 4-hydroxypiperidino resulted in a series of compounds, which showed in vitro activity with EC50 values in the low nanomolar range, and favorable kinetic properties, such as 40% oral bioavailability. The most promising compound was also tested in a swine in vivo model, resulting in a growth hormone level with a Cmax of over 40 ng mL-1.

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Benzothiophene – Wikipedia,
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Related Products of 254905-58-3. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate, is researched, Molecular C13H24N2O3, CAS is 254905-58-3, about Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations. Author is de la Fuente Revenga, Mario; Balle, Thomas; Jensen, Anders A.; Froelund, Bente.

Exploration of small selective ligands for the nicotinic acetylcholine receptors (nAChRs) based on acetylcholine (ACh) has led to the development of potent agonists with clear preference for the α4β2 nAChR, the most prevalent nAChR subtype in the central nervous system. In this work the authors present the continuation of these efforts aimed at increasing this subtype selectivity by introduction of conformational restriction in the carbamoylcholine homolog, 3-(dimethylaminobutyl) dimethylcarbamate (DMABC). The results highlight the importance of the N-carbamoyl substitution in α4β2-subtype selectivity. Moreover, the authors have confirmed the non-linear conformation of DMABC bound to nAChRs suggested by recent crystal structures of the compound in complex with the Lymnaea stagnalis ACh binding protein.

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Benzothiophene – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 254905-58-3, is researched, Molecular C13H24N2O3, about Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen, the main research direction is trisubstituted pyridine preparation bioavailability WNT signaling inhibitor antitumor.Recommanded Product: 254905-58-3.

WNT signaling is frequently deregulated in malignancy, particularly in colon cancer, and plays a key role in the generation and maintenance of cancer stem cells. The authors report the discovery and optimization of a 3,4,5-trisubstituted pyridine, 1-(3,5-Dichloropyridin-4-yl)piperidine-4-carboxamide (9), using a high-throughput cell-based reporter assay of WNT pathway activity. The authors demonstrate a twisted conformation about the pyridine-piperidine bond of (9) by small-mol. x-ray crystallog. Medicinal chem. optimization to maintain this twisted conformation, cognisant of physicochem. properties likely to maintain good cell permeability, led to 8-[3-Chloro-5-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]pyridin-4-yl]-2,8-diazaspiro[4,5]decan-1-one (74) (CCT251545), a potent small-mol. inhibitor of WNT signaling with good oral pharmacokinetics. The authors demonstrate inhibition of WNT pathway activity in a solid human tumor xenograft model with evidence for tumor growth inhibition following oral dosing. This work provides a successful example of hypothesis-driven medicinal chem. optimization from a singleton hit against a cell-based pathway assay without knowledge of the biochem. target.

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Benzothiophene – Wikipedia,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 254905-58-3, is researched, Molecular C13H24N2O3, about Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations, the main research direction is carbamoylcholine homolog pharmacol neuron nicotinic receptor ligand; Acetylcholine; Agonist; Conformational restriction; Docking; Nicotinic acetylcholine receptor.Recommanded Product: tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate.

Exploration of small selective ligands for the nicotinic acetylcholine receptors (nAChRs) based on acetylcholine (ACh) has led to the development of potent agonists with clear preference for the α4β2 nAChR, the most prevalent nAChR subtype in the central nervous system. In this work the authors present the continuation of these efforts aimed at increasing this subtype selectivity by introduction of conformational restriction in the carbamoylcholine homolog, 3-(dimethylaminobutyl) dimethylcarbamate (DMABC). The results highlight the importance of the N-carbamoyl substitution in α4β2-subtype selectivity. Moreover, the authors have confirmed the non-linear conformation of DMABC bound to nAChRs suggested by recent crystal structures of the compound in complex with the Lymnaea stagnalis ACh binding protein.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations, published in 2015-09-18, which mentions a compound: 254905-58-3, Name is tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate, Molecular C13H24N2O3, COA of Formula: C13H24N2O3.

Exploration of small selective ligands for the nicotinic acetylcholine receptors (nAChRs) based on acetylcholine (ACh) has led to the development of potent agonists with clear preference for the α4β2 nAChR, the most prevalent nAChR subtype in the central nervous system. In this work the authors present the continuation of these efforts aimed at increasing this subtype selectivity by introduction of conformational restriction in the carbamoylcholine homolog, 3-(dimethylaminobutyl) dimethylcarbamate (DMABC). The results highlight the importance of the N-carbamoyl substitution in α4β2-subtype selectivity. Moreover, the authors have confirmed the non-linear conformation of DMABC bound to nAChRs suggested by recent crystal structures of the compound in complex with the Lymnaea stagnalis ACh binding protein.

If you want to learn more about this compound(tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate)COA of Formula: C13H24N2O3, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(254905-58-3).

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Benzothiophene – Wikipedia,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 254905-58-3, is researched, SMILESS is O=C(N1CCC(C(N(C)C)=O)CC1)OC(C)(C)C, Molecular C13H24N2O3Journal, Article, European Journal of Medicinal Chemistry called The influence of conformational restriction in the C-terminus of growth hormone secretagogues on their potency, Author is Peschke, Bernd; Ankersen, Michael; Bauer, Michael; Hansen, Thomas Kruse; Hansen, Birgit Sehested; Nielsen, Karin Kramer; Raun, Kirsten; Richter, Lutz; Westergaard, Lisbet, the main research direction is growth hormone secretagogue structure activity C terminal conformation.Application of 254905-58-3.

In order to obtain more potent growth hormone secretagogues, a comparison of ipamorelin and NN703 suggested the addition of a polar group at the C-terminus of NN703. A study was conducted using constrained amines for this purpose. Here, substituted 4-piperidinylamino- and 4-dimethylaminopiperidino-substituents were found to give the most active compounds A replacement of the 4-dimethylaminopiperidino-substituent with 4-hydroxypiperidino resulted in a series of compounds, which showed in vitro activity with EC50 values in the low nanomolar range, and favorable kinetic properties, such as 40% oral bioavailability. The most promising compound was also tested in a swine in vivo model, resulting in a growth hormone level with a Cmax of over 40 ng mL-1.

From this literature《The influence of conformational restriction in the C-terminus of growth hormone secretagogues on their potency》,we know some information about this compound(254905-58-3)Application of 254905-58-3, but this is not all information, there are many literatures related to this compound(254905-58-3).

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations, published in 2015-09-18, which mentions a compound: 254905-58-3, Name is tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate, Molecular C13H24N2O3, Recommanded Product: 254905-58-3.

Exploration of small selective ligands for the nicotinic acetylcholine receptors (nAChRs) based on acetylcholine (ACh) has led to the development of potent agonists with clear preference for the α4β2 nAChR, the most prevalent nAChR subtype in the central nervous system. In this work the authors present the continuation of these efforts aimed at increasing this subtype selectivity by introduction of conformational restriction in the carbamoylcholine homolog, 3-(dimethylaminobutyl) dimethylcarbamate (DMABC). The results highlight the importance of the N-carbamoyl substitution in α4β2-subtype selectivity. Moreover, the authors have confirmed the non-linear conformation of DMABC bound to nAChRs suggested by recent crystal structures of the compound in complex with the Lymnaea stagnalis ACh binding protein.

If you want to learn more about this compound(tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate)Recommanded Product: 254905-58-3, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(254905-58-3).

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate, is researched, Molecular C13H24N2O3, CAS is 254905-58-3, about Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations.Synthetic Route of C13H24N2O3.

Exploration of small selective ligands for the nicotinic acetylcholine receptors (nAChRs) based on acetylcholine (ACh) has led to the development of potent agonists with clear preference for the α4β2 nAChR, the most prevalent nAChR subtype in the central nervous system. In this work the authors present the continuation of these efforts aimed at increasing this subtype selectivity by introduction of conformational restriction in the carbamoylcholine homolog, 3-(dimethylaminobutyl) dimethylcarbamate (DMABC). The results highlight the importance of the N-carbamoyl substitution in α4β2-subtype selectivity. Moreover, the authors have confirmed the non-linear conformation of DMABC bound to nAChRs suggested by recent crystal structures of the compound in complex with the Lymnaea stagnalis ACh binding protein.

If you want to learn more about this compound(tert-Butyl 4-(dimethylcarbamoyl)piperidine-1-carboxylate)Synthetic Route of C13H24N2O3, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(254905-58-3).

Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem