Tag: M.W:200-300

4923-87-9,4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Bromobenzothiophene (1.60 g, 7.51 mmol) and dichloromethyl methyl ether (1.29 g, 11.3 mmol) were dissolved in anhydrous 1,2-dichloroethane (75 mL). Titanium tetrachloride (2.14 g, 11.3 mmol) was added, turning the solution dark. After one hour at room temperature, the reaction was poured into a mixture of saturated aqueous NaHCO3 and ice. The mixture was stirred for about 30 minutes and then was extracted with DCM (2¡Á100 mL). The extracts were concentrated and chromatographed (0 to 5% ethyl acetate in hexane) to yield 5-bromo-benzo[b]thiophene-3-carbaldehyde (1.32 g). The 5-bromobenzothiophene-3-carboxaldehyde (1.20 g, 4.98 mmol) and sulfamide (4.0 g, 42 mmol) were combined in anhydrous ethanol (25 mL) and heated to reflux for three days. The reaction was cooled to room temperature and sodium borohydride (0.207 g, 5.47 mmol) was added. After five hours, water (50 ml) was added and the solution was extracted with chloroform (3¡Á50 mL). The extracts were concentrated, suspended in a minimal amount of DCM, and filtered to provide the title compound as a yellow solid.1H NMR (DMSO-d6): delta 8.12 (1H, d, J=1.8 Hz), 7.97 (1H, d, J=8.6), 7.71 (1H, s), 7.52 (1H, dd, J=8.6, 1.9 Hz), 7.12 (1H, t, J=6.3 Hz), 6.72 (2H, s), 4.28 (2H, d, J=6.2 Hz).

As the paragraph descriping shows that 4923-87-9 is playing an increasingly important role.

Reference£º
Patent; Smith-Swintosky, Virginia L.; US2007/191459; (2007); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1423-61-6, 7-Bromobenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under a nitrogen stream, of 12.2g (35.2mmol) 7-bromobenzo [b] thiophene, 6.44g of (38.7mmol) 2- nitrophenyl boronic acid, and NaOH of 4.22g (105.6mmol), 300ml / was stirred into a THF / H2O of 150ml. 40 put the Pd (PPh3) 4 of 2.03g (5mol%) in, and the mixture was stirred for 12 hours at 80 . After completion of the reaction, and extracted with methylene chloride, put MgSO4, and filtered. After removal of the solvent of the filtered organic layer, was obtained by column chromatography 7- (2-nitrophenyl) benzo [b] thiophene 7.38 g (28.9 mmol, 82% yield)., 1423-61-6

1423-61-6 7-Bromobenzo[b]thiophene 12045538, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; DOOSAN CORPORATION; KIM, TAE HYUNG; LEE, IN HYUK; KIM, HOE MOON; SHIN, JIN YONG; PARK, HO CHEOL; LEE, CHANG JUN; BEAK, YOUNG MI; LEE, EUN JUNG; (96 pag.)JP2015/527347; (2015); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

20699-85-8, Methyl 5-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The freshly prepared above acid chloride (1 equiv.) in CH2CI2 was added to a solution of compound 6-Amino-benzo[b]thiophene-2-carboxylic acid methyl ester (1 equiv.) in CH2CI2 and DIEA (1.1 equiv.). Reaction mixture was stirred for 3 hours at rt resulting in an orange gel-like suspension. It was then filtered and the residue was washed extensively with MeOH and dried under vacuum, yielding the product 5-[2-(9H-Fluoren- theta-ylmethoxycarbonylaminoJ-S-phenyl-propionylaminol-benzotbJthiophene^-carboxylic acid methyl ester as white solid. Yield: 87%., 20699-85-8

Big data shows that 20699-85-8 is playing an increasingly important role.

Reference£º
Patent; S*BIO PTE LTD; WO2006/101454; (2006); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

j00348j To a solution of 5-bromobenzo[bjthiophene (2.0 g, 9.4 mmol) in tetrahydrofuran (20 mL)at -70C under nitrogen was added dropwise lithium diisopropylamide (2 M in tetrahydrofuran, 5.6mL, 11 mmol). The solution was stirred at -70C for 1 hour, and then iodomethane (2.0 g, 14mmol) was added. The resulting solution was stirred at -70C for 2 hours and at room temperature foranother 13 hours, then poured into 5% hydrochloric acid (100 mL) and extracted with ethyl acetate (2x 100 mL). The combined organic layers were washed with aqueous sodium bicarbonate (2 x 30 mL)and concentrated in vacuo. The residue was purified by flash column chramotagraphy [100%petroleum etherj to give compound B-38 (1.9 g, 89% yield) as a white solid. 1H-NMR (CDC13, 400MHz): 7.80 (d, J=2.0 Hz, 1H), 7.61 (d, J=8.4 Hz, 1H), 7.36 (dd, J18.4 Hz, J21.6 Hz, 1H), 6.93 (s,1H), 2.61 (s, 3H)

4923-87-9, As the paragraph descriping shows that 4923-87-9 is playing an increasingly important role.

Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; McRINER, Andrew, J.; (267 pag.)WO2017/69980; (2017); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

Preparation 1064-Benzo[b]thiophen-7-yl-3-methoxymethoxy -pyridine Solution A: Treat a solution of 3 -methoxymethoxy -pyridine (2.5 g, 18 mmol) in diethyl ether (90 mL) at -70 0C with tert-butyl lithium (1.7 M in pentane, 10 mL, 18 mmol) dropwise over 10 min. Stir the mixture at -70 0C for 40 min and add a solution of triisopropyl borate (5 mL, 22 mmol) in THF (10 mL) dropwise over 5 min. Stir the mixture at -70 0C for 1 h and then remove the ice bath and allow the mixture to slowly warm to RT. Solution B: Treat a solution of 7-bromo-benzo[b]thiophene (3.8 g, 18 mmol), 2- (di-tert-butylphosphino)biphenyl (268 mg, 0.90 mmol), Pd(dppf)Cl2 (732 mg, 0.90 mmol) in 1,4-dioxane (30 mL) with 2 M aqueous sodium carbonate (72 mL, 36 mmol). Heat the solution to 80 0C once solution A reaches RT. Treat solution B with solution A dropwise over 10 min. Heat the combined solution to 85 0C for 5 h. Cool the mixture to RT and dilute with ethyl acetate and water. Wash the organic phase with water and aqueous saturated sodium chloride, dry over sodium sulfate, filter, and concentrate in vacuo. Purify the residue by column chromatography on 12O g silica gel eluting with a gradient of DCM to ethyl acetate to give the title compound (3.8 g) containing some starting 3-methoxymethoxy-pyridine. 1H NMR (400 MHz, CDCl3) delta 8.68 (s, IH), 8.42 (d, J= 4 Hz, IH), 7.88 (d, J= 8 Hz, IH), 7.33-7.50 (m, 5H), 5.12 (s, 2H), 3.36 (s, 3H)., 1423-61-6

As the paragraph descriping shows that 1423-61-6 is playing an increasingly important role.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2008/144222; (2008); A2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20699-85-8,Methyl 5-aminobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

To a mixture of compound 133 (508 mg, 2.106 mmol) and compound 61 (300 mg, 1.404 mmol) in DMF (7.021 mL) was added EDC (567 mg, 2.81 mmol) and DMAP (429 mg, 3.51 mmol) at rt. After stirring for 3 h, the reaction was diluted with EtOAc and then washed with water, sat?d aq. NaHC03 and brine. The organic layer was dried over MgS04, filtered and concentrated to obtain compound 138, which was used in the next step without purification (0.6 g, 100% yield). LCMS = 8.36 min (15 min method). Mass observed (EST): 429.0 (M-H).

20699-85-8, The synthetic route of 20699-85-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IMMUNOGEN, INC.; MILLER, Michael, Louis; SHIZUKA, Manami; CHARI, Ravi, V.J.; (312 pag.)WO2019/133652; (2019); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

10133-22-9, 5-(Bromomethyl)benzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The following compounds were obtained in an analogous manner to that described in Example 46(d)-(e) and, respectively, 3(c)-(e): 1)–From tert-butyl (3RS,4RS)-3-hydroxy-4-[4-[3-(2-phenyl-[1,3]dioxolan-2-yl)-propoxy]-phenyl]-piperidine-1-carboxylate by alkylation with 5-bromomethyl-benzo[b]thiophene there was obtained tert-butyl (3RS,4RS)-3-(benzo[b]thiophen-5-ylmethoxy)-4-{4-[3-(2-phenyl-[1,3]dioxolan-2-yl)-propoxy]-phenyl}-piperidine-1-carboxylate, MS: 630 (M+H)+, as a light yellow resin., 10133-22-9

As the paragraph descriping shows that 10133-22-9 is playing an increasingly important role.

Reference£º
Patent; Hoffmann-La Roche Inc.; US6051712; (2000); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20699-86-9,Methyl 5-nitrobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

Step 2: Methyl-5-amino-benzo[b]thiophene-2-carboxylate (588) A suspension of 584 (3.52 g, 14.8 mmol) in methanol (100 ml) was treated with Fe powder (6.63 g, 118.7 mmol). The resulting suspension was heated to reflux, and 12M HCl (8.5 ml) was slowly added over 15 min. The resulting green dark suspension was refluxed for an additional 3 h, then cooled and concentrated. The residue was taken up in EtOAc and washed with saturated aqueous NaHCO3, then brine, dried over MgSO4, filtered and concentrated to afford (2.57 g, 84%). 1H NMR: (DMSO) delta (ppm): 7.92 (s, 1H), 7.65 (d, J=8.8 Hz, 1H), 7.05 (d, J=1.5 Hz, 1H), 6.88 (dd, J=1.8, 8.4 Hz, 1H), 5.27 (s, 2H), 3.85 (s, 3H). LRMS: 207.0 (Calc.). 208.1 (found).

20699-86-9, As the paragraph descriping shows that 20699-86-9 is playing an increasingly important role.

Reference£º
Patent; MethylGene, Inc.; US6897220; (2005); B2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

17347-32-9, 6-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 6-bromobenzothiophene (500 mg, 2.35 mmol) in DMF (6 ml) was added Zn(CN)2 (413 mg, 3.52 mmol) and Pd(PPh3)4 (136 mg, 0.117 mmol). The reaction was heated in the microwave to 100 C for 30 min. The mixture was filtered through a pad of Celite with EtOAc, the solvents were removed in vacuo and the crude product was purified by flash chromatography using 10-20%) EtOAc in n- heptane as eluent. Yield: 325 mg (87%); yellow solid. HPLC purity: 100 %.

17347-32-9, The synthetic route of 17347-32-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KANCERA AB; HAMMER, Kristin; JOeNSSON, Mattias; KRUeGER, Lars; (230 pag.)WO2017/108282; (2017); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4923-87-9,5-Bromobenzothiophene,as a common compound, the synthetic route is as follows.

Instead of 6-bromo -1H- indole, 5-bromobenzo [b] but using thiophene, as in Preparation Example 1 above 2- (benzo [b] thiophen-5-yl ) 4,4,5,5 to obtain a tetra-methyl-1,3,2-dioxaborolane.

4923-87-9, 4923-87-9 5-Bromobenzothiophene 2776578, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; DOOSAN CORPORATION; KIM, HOE MOON; BEAK, YOUNG MI; KIM, TAE HYUNG; PARK, HO CHEOL; LEE, CHANG JUN; SHIN, JIN YONG; (68 pag.)JP2015/531758; (2015); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem