Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

2-Nitrophenylboronic acid, 4.22 g (105.6 mmol) of NaOH and 300 ml / 150 ml of THF / H2O were added to a solution of 12.2 g (35.2 mmol) of 7-bromobenzo [b] thiophene and 6.44 g Lt; / RTI & gt; 2.03 g (5 mol%) of Pd (PPh3) 4 was added at 40 deg. C and the mixture was stirred at 80 deg. C for 12 hours. After completion of the reaction, the reaction mixture was extracted with methylene chloride, and the residue was filtered with MgSO4. After removing the solvent of the filtered organic layer, 7- (2-nitrophenyl) benzo [b] thiophene (7.38 g, yield: 82%) was obtained by column chromatography., 1423-61-6

As the paragraph descriping shows that 1423-61-6 is playing an increasingly important role.

Reference£º
Patent; Doosan Co., ltd; Kim, Tae Hyoung; Kim, Song Mu; Lee, Chang Jun; Sin, Jin Yong; Baek, Young Mi; Park, Ho Chul; (40 pag.)KR101599586; (2016); B1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10133-22-9,5-(Bromomethyl)benzo[b]thiophene,as a common compound, the synthetic route is as follows.

Add potassium carbonate (0.619 g, 4.4 mmol, 1.6 eq) followed by 5-bromomethyl- benzo [b] thiophene (17.7 g, 78 mmol, 1 eq) in one portion to a stirred solution of 1,1- dimethylethyl 4- [ (2-methylpropyl) amino] piperidine-1-carboxylate (20 g, 78 mmol, 1 eq) in acetonitrile (400 ml). Cool, add water (250 ml) then filter. Wash the solid with ice cold acetonitrile and leave to dry on sinter for 1 hr. Purify on a 330 g Redisep column (20 g per column) using a gradient of 0-40% Ethyl acetate/iso-hexane to give 1,1- dimethylethyl 4- { [ (l-benzothienyl-5-yl] methyl]- (2-methylpropyl) amino}-piperidine-1- carboxylate (7.64 g, 46 %) as yellow solid. LCMS Rt= 3.38 (6 min gradient) M++1 : 403.5. 1H NMR (300 MHz, CDC13) 6 ppm 7.80-7. 60 (2 H, m), 7.37-7. 33 (1 H, m), 7.32- 7.26 (1 H, m), 7.25-7. 20 (1 H, m), 4.17-3. 94 (2 H, m), 3.65 (2 H, s), 2.65-2. 36 (3 H, m), 2.24-2. 10 (2 H, d), 1.71-1. 28 (5 H, m), 1.38 (9 H, s), 0.88-0. 69 (6 H, d).

10133-22-9, As the paragraph descriping shows that 10133-22-9 is playing an increasingly important role.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/92885; (2005); A1;,
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Benzothiophene | C8H6S – PubChem

20699-85-8, Methyl 5-aminobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of compound 4 (100 mg, 0.237 mmol) and compound 78 (132 mg, 0.355 mmol) indichloromethane (2.3 mL) was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (71.6 mg,0.355 mmol) and 4-dimethylaminopyridine (14.45 mg, 0.118 mmol) at room temperature. Afterstirring for 2 h, the mixture was extracted with dichloromethane and water. The organic layer wasdried over magnesium sulfate, filtered, and concentrated. The crude material was purified by silicagel chromatography (dichloromethane/methanol), followed by RP-HPLC (C18 Kromasil,acetonitrile/water) to yield compound 18 (50 mg, 33% yield)., 20699-85-8

The synthetic route of 20699-85-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Reid, Emily E.; Archer, Katie E.; Shizuka, Manami; McShea, Molly A.; Maloney, Erin K.; Ab, Olga; Lanieri, Leanne; Wilhelm, Alan; Ponte, Jose F.; Yoder, Nicholas C.; Chari, Ravi V.J.; Miller, Michael L.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 17; (2019); p. 2455 – 2458;,
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Benzothiophene | C8H6S – PubChem

104795-85-9, Methyl 6-chlorobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The solution of compound 2a-2n (1.1 mmol) in water (10 mL)was stirred and then potassium hydroxide pellets (5.4 mmol) wereadded, which was refluxed for 3 h. The aqueous layer was thenacidified to pH 1 with 1M hydrochloric acid solution. The aqueouslayer was extracted with dichloromethane (3 x 15 mL). The combinedorganic layers were dried with sodium sulfate, filtered, andthe solvents were removed under reduced pressure to afford thetitle compound 3a-3n [31,34].

104795-85-9, As the paragraph descriping shows that 104795-85-9 is playing an increasingly important role.

Reference£º
Article; Cai, Guiping; Yu, Wenying; Song, Dongmei; Zhang, Wenda; Guo, Jianpeng; Zhu, Jiawen; Ren, Yuhao; Kong, Lingyi; European Journal of Medicinal Chemistry; vol. 174; (2019); p. 236 – 251;,
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4923-87-9, 5-Bromobenzothiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,4923-87-9

Step A: 5-Bromo- 1 -benzothiophene 1 J -dioxide5-Bromo- 1 -benzothiophene (1.50 g, 7.04 mmol) was dissolved in chloroform (47 mL) and allowed to stir vigorously at ambient temperature. m-CPBA (4.34 g, 17.6 mmol) was added in three portions and the resulting mixture was maintained at ambient temperature for 16 hours. The mixture was then diluted with 1M aqueous sodium thiosulfate and extracted with EtOAc. The organic layer was again washed with 1M aqueous sodium thiosulfate, saturated aqueous NaHC03, brine, dried over anhydrous MgS04, filtered, and concentrated in vacuo. The residue was purified by MPLC on silica gel (using a gradient elution of 0-30% EtOAc/hexanes). Desired fractions were identified, combined, and concentrated in vacuo to afford the title compound. 1H NMR (600 MHz, CDC13): delta 7.65 (dd, J= 7.9, 1.8 Hz, 1H), 7.55 (d, J= 7.9 Hz, 1H), 7.50 (d, J= 1.8 Hz, 1H), 7.15 (d, J= 6.9 Hz, 1H), 6.74 (d, J= 6.9 Hz, 1H).

As the paragraph descriping shows that 4923-87-9 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; BRUBAKER, Jason; DINSMORE, Christopher J.; HOFFMAN, Dawn Marie; JUNG, Joon; LIU, Duan; PETERSON, Scott; SIU, Tony; TORRES, Luis E.; ZHANG, Hongjun; WEI, Zhongyong; SHI, Feng; WO2013/40863; (2013); A1;,
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Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10133-22-9,5-(Bromomethyl)benzo[b]thiophene,as a common compound, the synthetic route is as follows.

10133-22-9, 5-(Bromomethyl)benzo[b]thiophene (312 mg, 1.37 mmol) and 7 thiourea (35 mg, 0.46 mmol) were dissolved in 8 ethanol (10 mL). The reaction mixture was refluxed for 2 hours. The reaction mixture was cooled, and ethanol was removed under reduced pressure. The resulting residue was suspended in dichloromethane. The suspension was filtered to give a product as a white solid (117 mg, 84%); 1H NMR (300 MHz) (DMSO-d6) delta 9.16 (bs, 2H), 8.94 (bs, 2H), 8.01 (d, J=8 Hz, 1H), 7.90 (s, 1H), 7.81 (d, J=5 Hz, 1H), 7.45 (d, J=6 Hz, 1H), 7.39 (d, J=8 Hz, 1H), 4.58 (s, 2H); LC/MS RT=2.50 (M+H+: 223).

10133-22-9 5-(Bromomethyl)benzo[b]thiophene 11160498, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; TAXIS PHARMACEUTICALS, INC.; LaVoie, Edmond J.; Parhi, Ajit K.; Sun, Yangsheng; (77 pag.)US2019/31624; (2019); A1;,
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Benzothiophene | C8H6S – PubChem

89673-36-9, tert-Butyl benzo[b]thiophen-2-ylcarbamate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,89673-36-9

Benzo[Z>]thiophen-2-ylamine hydrochloride (1-C).; Compound 1-B (1.45 g, 5.81 mmol) was added to a solution of HCl in dioxane (4 N, 20 mL), and the mixture was stirred at rt until all the starting material was consumed. The mixture was diluted with diethyl ether, the product collected by filtration, and washed with diethyl ether, to afford compound 1-C as an off-white solid (0.89 g, 83%). 1H-NMR (DMSO-fe): delta 6.43 (s, IH), 6.8-7.2 (br s, 3H) superimposed on 7.05 (m, IH) and 7.20 (m, IH), 7.45 (d, IH), 7.66 (d, IH); MS: m/z 150.1 (MH+).

89673-36-9 tert-Butyl benzo[b]thiophen-2-ylcarbamate 13182766, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2009/12430; (2009); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

Scheme I, step C: 7-bromobenzo(b)thiophene (3.01 g, 14.1 mmol, prepared above in step B) is dissolved in diethyl ether (20 mL) and the solution is added dropwise to a suspension of magnesium (0.69 g, 28.3 mmol) in diethyl ether (20 mL). Dibromoethane (1.22 mL, 14.1 mmol) in diethyl ether (10 mL) is then added dropwise to the reaction mixture, which is then heated to reflux for 3 hours. The reaction is then cooled to room temperature and 1-(t-butoxycarbonyl)-3-pyrrolidone (14.1 mmol, prepared following the procedure described in Synlett., 1, 55-57 (1995)) is added. The reaction is stirred overnight at room temperature. Water is then added to the reaction, and the mixture is extracted with diethyl ether. The organic layers are combined, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum. The residue is purified by flash chromatography (hexane:ethyl acetate, 7:3, silica gel) to provide 1-(t-butoxycarbonyl)-3-(7-benzo(b)thiophene)-3-hydroxy pyrrolidine.

1423-61-6, The synthetic route of 1423-61-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Eli Lilly and Company; US6353008; (2002); B1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.360575-29-7,Methyl 4-bromobenzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.

After dissolving methyl 4-bromobenzo [b] thiophene-2-carboxylate (1 eq) in dimethylene glycol ether (DME), tetrakis (triphenylphosphine) palladium (0) (Pd (PPh3) 4, 0.02 eq), 4-fluorophenylboronic acid (1.1 eq) and 2M sodium carbonate (2M Na2CO3, 5 eq) The mixture was stirred at 60 DEG C for 5 hours. The reaction solution was cooled to room temperature, filtered through Celite, and the reaction filtrate was washed with water and EtOAc and extracted. A small amount of water in the organic layer was removed with anhydrous MgSO 4, the solvent was removed by distillation under reduced pressure, and the product was separated into a column to obtain the target compound in 92% yield., 360575-29-7

The synthetic route of 360575-29-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chungnam National University Industry-Academic Cooperation Foundation; Kim, Uhn Hee; Yu, Sung Uhn; Kang, Nam Sook; Ku, Tae Sung; Park, Min Young; Kim, Young Hun; Bae, Hyun Ju; Kim, Jin Woo; In, Tae Gyu; Ju, Chun Gi; (44 pag.)KR101515985; (2015); B1;,
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Benzothiophene | C8H6S – PubChem

360576-01-8, Methyl 6-bromobenzo[b]thiophene-2-carboxylate is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Ausgehend von 4.0 g (14.8 mmol) [6-BROM-L-BENZOTHIOPHEN-2-CARBONSaeUREMETHYL-] ester (aus Beispiel 9A) werden nach der allgemeinen Arbeitsvorschrift B 3.55 g (94 % d. Th. ) des gewuenschten Produkts erhalten. 1H-NMR (400 MHz, [DMSO-D6): No. = 13. ]48 (br. [S,] [1H),] 8. 38 (s, [1H),] 8.22 (s, [1H),] 7.96 (d, 1H), 7.63 [(M,] 1H). HPLC (Methode [1)] : Rt = 4.5 min.

360576-01-8, As the paragraph descriping shows that 360576-01-8 is playing an increasingly important role.

Reference£º
Patent; BAYER HEALTHCARE AG; WO2003/104227; (2003); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem