Tag: M.W:200-300

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18494-87-6,Benzothiophene-3-sulfonyl chloride,as a common compound, the synthetic route is as follows.

Example 393; 7-[1-(1-benzothien-3-ylsulfonyl)piperidin-4-yl]-3,3-dimethyl-2-oxa-7-azaspiro[4.5]decan-1-one; [Show Image] To a solution of 3,3-dimethyl-7-(piperidin-4-yl)-2-oxa-7-azaspiro[4.5]decan-1-one dihydrochloride (150 mg, 0.442 mmol) obtained in Reference Example 53 and triethylamine (0.215 mL, 1.55 mmol) in THF (2 mL) was added 1-benzothiophene-3-sulfonyl chloride (103 mg, 0.442 mmol), and the mixture was stirred at room temperature for 3 hr. The reaction mixture was diluted with ethyl acetate, washed with aqueous potassium carbonate solution and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the obtained residue was purified by basic silica gel column chromatography (developing solvent; ethyl acetate) to give the title compound (180 mg, yield 88%). EI(pos) 463 [M+H]+, 18494-87-6

18494-87-6 Benzothiophene-3-sulfonyl chloride 2776340, abenzothiophene compound, is more and more widely used in various fields.

Reference：
Patent; Takeda Pharmaceutical Company Limited; EP1911753; (2008); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18494-87-6,Benzothiophene-3-sulfonyl chloride,as a common compound, the synthetic route is as follows.

Example 393; 7-[1-(1-benzothien-3-ylsulfonyl)piperidin-4-yl]-3,3-dimethyl-2-oxa-7-azaspiro[4.5]decan-1-one; [Show Image] To a solution of 3,3-dimethyl-7-(piperidin-4-yl)-2-oxa-7-azaspiro[4.5]decan-1-one dihydrochloride (150 mg, 0.442 mmol) obtained in Reference Example 53 and triethylamine (0.215 mL, 1.55 mmol) in THF (2 mL) was added 1-benzothiophene-3-sulfonyl chloride (103 mg, 0.442 mmol), and the mixture was stirred at room temperature for 3 hr. The reaction mixture was diluted with ethyl acetate, washed with aqueous potassium carbonate solution and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the obtained residue was purified by basic silica gel column chromatography (developing solvent; ethyl acetate) to give the title compound (180 mg, yield 88%). EI(pos) 463 [M+H]+, 18494-87-6

18494-87-6 Benzothiophene-3-sulfonyl chloride 2776340, abenzothiophene compound, is more and more widely used in various fields.

Reference：
Patent; Takeda Pharmaceutical Company Limited; EP1911753; (2008); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18494-87-6,Benzothiophene-3-sulfonyl chloride,as a common compound, the synthetic route is as follows.

Example 393; 7-[1-(1-benzothien-3-ylsulfonyl)piperidin-4-yl]-3,3-dimethyl-2-oxa-7-azaspiro[4.5]decan-1-one; [Show Image] To a solution of 3,3-dimethyl-7-(piperidin-4-yl)-2-oxa-7-azaspiro[4.5]decan-1-one dihydrochloride (150 mg, 0.442 mmol) obtained in Reference Example 53 and triethylamine (0.215 mL, 1.55 mmol) in THF (2 mL) was added 1-benzothiophene-3-sulfonyl chloride (103 mg, 0.442 mmol), and the mixture was stirred at room temperature for 3 hr. The reaction mixture was diluted with ethyl acetate, washed with aqueous potassium carbonate solution and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the obtained residue was purified by basic silica gel column chromatography (developing solvent; ethyl acetate) to give the title compound (180 mg, yield 88%). EI(pos) 463 [M+H]+, 18494-87-6

18494-87-6 Benzothiophene-3-sulfonyl chloride 2776340, abenzothiophene compound, is more and more widely used in various fields.

Reference：
Patent; Takeda Pharmaceutical Company Limited; EP1911753; (2008); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18494-87-6,Benzothiophene-3-sulfonyl chloride,as a common compound, the synthetic route is as follows.

Example 393; 7-[1-(1-benzothien-3-ylsulfonyl)piperidin-4-yl]-3,3-dimethyl-2-oxa-7-azaspiro[4.5]decan-1-one; [Show Image] To a solution of 3,3-dimethyl-7-(piperidin-4-yl)-2-oxa-7-azaspiro[4.5]decan-1-one dihydrochloride (150 mg, 0.442 mmol) obtained in Reference Example 53 and triethylamine (0.215 mL, 1.55 mmol) in THF (2 mL) was added 1-benzothiophene-3-sulfonyl chloride (103 mg, 0.442 mmol), and the mixture was stirred at room temperature for 3 hr. The reaction mixture was diluted with ethyl acetate, washed with aqueous potassium carbonate solution and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the obtained residue was purified by basic silica gel column chromatography (developing solvent; ethyl acetate) to give the title compound (180 mg, yield 88%). EI(pos) 463 [M+H]+, 18494-87-6

18494-87-6 Benzothiophene-3-sulfonyl chloride 2776340, abenzothiophene compound, is more and more widely used in various fields.

Reference：
Patent; Takeda Pharmaceutical Company Limited; EP1911753; (2008); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. Electric Literature of 360576-01-8, C10H7BrO2S. A document type is Patent, introducing its new discovery., Electric Literature of 360576-01-8

Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.

We very much hope you enjoy reading the articles and that you will join us to present your own research about 360576-01-8, Electric Literature of 360576-01-8

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Electric Literature of 35212-85-2, Chemical research careers are more diverse than they might first appear, as there are many different reasons to conduct research and many possible environments. In a article, 35212-85-2, molcular formula is C10H9NO2S, introducing its new discovery.

Methyl and phenyl derivatives containing the [1]Benzothieno[3,2-d]pyrimidin-4-one system have been synthesized and tested as inhibitors of COX-1 and COX-2 activities in human whole blood (HWB) ex vivo; all compounds turned out to be weak inhibitors of COX- 1 activity, as deduced from the TXB2 (thromboxane B) generation; the acid phenyl derivative 11 b was an interesting inhibitor of COX-2 activity, as deduced from the PGE2 (prostaglandine E) generation.

Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.Read on for other articles about 35212-85-2

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Formula: C8H5BrS, Chemical Research Letters, May 2021. This type of reactivity has quickly become one of the cornerstones of modern catalysis . In a article, 4923-87-9, molcular formula is C8H5BrS, introducing its new discovery.

The present invention relates to a novel compound and an organic electroluminescence device including the same, and the compound according to the present invention may be used in an organic material layer, preferably a light-emitting layer of an organic electroluminescence device, thereby enhancing the light-emitting efficiency, driving voltage, lifespan, and the like of the organic electroluminescence device.

Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 4923-87-9. Formula: C8H5BrS

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Related Products of 10243-15-9, Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In a article, 10243-15-9, molcular formula is C9H7BrS, introducing its new discovery.

“Chemical Equation Presented” Cive me an “F”: Electrophilic fluorination of various aromatic and heteroaromatic Grignard reagents is smoothly performed with (PhSO2)2NF as fluorinating agent in a 4:1 mixture of CH2Cl2/ perfluorodecalin (see scheme). This solvent system allows minimization of most side reactions.

Keep reading other articles of 10243-15-9, Related Products of 10243-15-9, Don’t worry, you don’t need a PhD in chemistry to understand the explanations!

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. Related Products of 6287-82-7

A new methodology involving 1,7-dipolar cyclizations of conjugated dipoles followed by a multistep rearrangement affording ring-contracted products has been employed for the synthesis of various examples of the title compounds.Under different thermolysis conditions the annulated alkynyl nitrones 15-19, 45, and 46 are converted into isoannulated pyrroles and alpha-pyridones, respectively, with yields up to 90percent (general reaction A –> B + C).The product distribution is strongly influenced by the nature of the thermal substituent R, hence supporting a mechanism with oxo carbenes as central intermediates which undergo either 6-? cyclization to the pyrrole systems or Wolff rearrangement leading to conjugated ketenes, the precursors of the observed alpha-pyridones (see Scheme 1).Diels-Alder reactions were performed with benzofuropyridone 40a, naphthopyridone 62 as well as with the corresponding dihydronaphtho compounds 64a, b.Whereas the tert-butyl derivatives 22b, 23b and 41b are rather unreactive against dienophiles, they are easily transformed into the cyclic imides 31, 32 and 52, respectively, under the influence of oxygen anf light suggesting the formation and subsequent <4 + 2> cycloaddition of 1O2 as important steps. – Key Words: Pyrroles, heteroannulated / alpha-Pyridones, heteroannulated / Pentalenes, dihetero- / Nitrones / Heterocyclizations, 1,7-dipolar / Diels-Alder reactions / Singlet oxygen

Interested yet? This just the tip of the iceberg, You can reading other blog about 6287-82-7. Related Products of 6287-82-7

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Reference of 20699-85-8, Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects.

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 20699-85-8

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem