Tag: M.W:300-400

Chemistry is traditionally divided into organic and inorganic chemistry. category: benzothiophene, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 1034305-17-3

A concise and practical stereoselective synthesis of ipragliflozin L-proline was presented starting from 2-[(5-iodo-2-fluorophenyl)methyl]-1-benzothiophene and 2,3,4,6-tetra-O-pivaloyl-alpha-D-glucopyranosyl bromide without catalyst via iodine?lithium?zinc exchange. The overall yield was 52% in three steps and the product purity was excellent. Two key diastereomers were prepared with efficient and direct access to the alpha-C-arylglucoside.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Synthetic Route of 1034305-17-3, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 1034305-17-3, 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene, introducing its new discovery.

The subject of this invention is to provide a high efficiency and industrial conditions in order to facilitate manufacturing C-glycoside derivative technology. Use of the aryl magnesium acid salt (aryl magnesate) the coupling reaction, thereby can prevent the ultra-low temperature reaction, and at the same time, can be short time and high-yield manufacturing C-glycoside derivative. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 1034305-17-3. In my other articles, you can also check out more blogs about 1034305-17-3

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring.Recommanded Product: 4-(6-((Methylsulfonyl)oxy)benzo[b]thiophen-2-yl)phenyl methanesulfonate, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 84449-65-0, Name is 4-(6-((Methylsulfonyl)oxy)benzo[b]thiophen-2-yl)phenyl methanesulfonate, molecular formula is C16H14O6S3

The use of particularly advantageous protecting groups for the hydroxy groups of 6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophenes provides a high-yielding process for the preparation of such compounds having a 4-(2-aminoethoxy)benzoyl 3-group.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 84449-65-0, and how the biochemistry of the body works.Recommanded Product: 4-(6-((Methylsulfonyl)oxy)benzo[b]thiophen-2-yl)phenyl methanesulfonate

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Related Products of 1034305-17-3, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1034305-17-3, molcular formula is C15H10BrFS, introducing its new discovery.

The invention discloses a method for synthesizing the Iraqi gliclazide net method, comprises the following steps: (1) of formula 4 with a compound of the formula 5 compound that alkylation reaction formula 6 compound; (2) the formula 6 compound deprotection of formula 7 compounds, namely the Iraqi gliclazide net. The invention discloses a preparation method relative to the prior art, the use of the starting raw material is cheap, synthetic route is relatively short, the operation is simple, and the cost is low, the overall yield is relatively high, consistent with the concept of green chemistry, is suitable for industrial production. (by machine translation)

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1034305-17-3 is helpful to your research. Related Products of 1034305-17-3

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

84449-65-0, Name is 4-(6-((Methylsulfonyl)oxy)benzo[b]thiophen-2-yl)phenyl methanesulfonate, belongs to benzothiophene compound, is a common compound. HPLC of Formula: C16H14O6S3In an article, once mentioned the new application about 84449-65-0.

6-Hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene, its ethers and esters, and the physiologically acceptable acid addition salts thereof, are valuable antiestrogens and antiendrogens.

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

1034305-17-3, Name is 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene, belongs to benzothiophene compound, is a common compound. Application In Synthesis of 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiopheneIn an article, once mentioned the new application about 1034305-17-3.

The invention discloses a 2 – (5 – bromo – 2 – fluorobenzyl) benzo thiophene synthetic method, in order to 2 – fluoro – 5 – bromobenzene as a raw material, under the action of alkali through condensation and reduction shall be the target compound, comprising a condensation reaction and the reduction reaction, the present invention only two-step reaction to obtain the target compound, reduces the material varieties, improving the operating efficiency. The present invention not using a boron trifluoride ether and other chemicals, and does not use the like sodium borohydride as the reducing agent is not suitable for industrial scale, without the need for ultra-low temperature thereby reducing the production cost, in short synthetic method of this invention has mild reaction condition, simple process operation, environmental protection, low cost, and high yield. (by machine translation)

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

1034305-11-7, Name is Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol, belongs to benzothiophene compound, is a common compound. Safety of Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanolIn an article, once mentioned the new application about 1034305-11-7.

A synthesis method of the Iraqi gliclazide net (by machine translation)

The invention discloses a method for synthesizing the Iraqi gliclazide net method, comprises the following steps: (1) of formula 4 with a compound of the formula 5 compound that alkylation reaction formula 6 compound; (2) the formula 6 compound deprotection of formula 7 compounds, namely the Iraqi gliclazide net. The invention discloses a preparation method relative to the prior art, the use of the starting raw material is cheap, synthetic route is relatively short, the operation is simple, and the cost is low, the overall yield is relatively high, consistent with the concept of green chemistry, is suitable for industrial production. (by machine translation)

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Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Electric Literature of 1034305-17-3, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 1034305-17-3, 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene, introducing its new discovery.

Ni-Catalyzed Suzuki-Miyaura Cross-Coupling of alpha-Oxo-vinylsulfones to Prepare C-Aryl Glycals and Acyclic Vinyl Ethers

We demonstrate that readily available and bench-stable alpha-oxo-vinylsulfones are competent electrophiles in Ni-catalyzed Suzuki-Miyaura cross-coupling reactions. The C-sulfone bond in the alpha-oxo-vinylsulfone motif is cleaved chemoselectively in these reactions, furnishing C-aryl glycals or acyclic vinyl ethers in high yields. These reactions proceed under mild conditions and tolerate a remarkable scope of heterocycles and functional groups. Preliminary mechanistic studies revealed the importance of an alpha-heteroatom in facilitating these transformations.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 1034305-17-3. In my other articles, you can also check out more blogs about 1034305-17-3

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Related Products of 1034305-11-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 1034305-11-7, Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol, introducing its new discovery.

A 2 – (5 – bromo -2 – fluorobenzyl) benzo thiophene synthetic method (by machine translation)

The invention discloses a 2 – (5 – bromo – 2 – fluorobenzyl) benzo thiophene synthetic method, in order to 2 – fluoro – 5 – bromobenzene as a raw material, under the action of alkali through condensation and reduction shall be the target compound, comprising a condensation reaction and the reduction reaction, the present invention only two-step reaction to obtain the target compound, reduces the material varieties, improving the operating efficiency. The present invention not using a boron trifluoride ether and other chemicals, and does not use the like sodium borohydride as the reducing agent is not suitable for industrial scale, without the need for ultra-low temperature thereby reducing the production cost, in short synthetic method of this invention has mild reaction condition, simple process operation, environmental protection, low cost, and high yield. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Related Products of 1034305-11-7. In my other articles, you can also check out more blogs about 1034305-11-7

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

84449-65-0, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 84449-65-0, Name is 4-(6-((Methylsulfonyl)oxy)benzo[b]thiophen-2-yl)phenyl methanesulfonate,introducing its new discovery.

Antiestrogens. 2. Structure-Activity Studies in a Series of 3-Aroyl-2-arylbenzothiophene Derivatives Leading to <6-Hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl><4-<2-(1-piperidinyl)ethoxy>phenyl>methanone Hydrochloride (LY156758), a Remarkably Effective Estrogen Antagonist with On…

In an effort to prepare nonsteroidal antiestrogens demonstrating greater antagonism and less intrinsic estrogenicity than those currently available, a series of 3-aroyl-2-arylbenzothiophene derivatives was synthesized.These compounds were prepared by Friedel-Crafts aroylation of appropriate O-protected 2-arylbenzothiophene nuclei with basic side-chain-bearing benzoyl chlorides followed by removal of the protective groups to provide the desired compounds containing both hydroxyl and basic side-chain functionality.A particularly useful method for the cleavage of aryl methoxy ethers without removal of (dialkylamino)ethoxy side chain functionality elsewhere in the molecule was found to be AlCl3/EtSH.The benzothiophene derivatives were tested for their ability to inhibit the growth-stimulating action of estradiol on the immature rat uterus.Seemingly minor changes in the side-chain amine moiety were found to have profound effects on the ability of the compounds to antagonize estradiol.Analogues having basic side chains containing cyclic (pyrrolidine, piperidine, and hexamethyleneamine) moieties were found to have less intrinsic estrogenicity and to antagonize estradiol action more completely than their noncyclic counterparts.The most effective antiestrogen in the series, compound 44, <6-hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl><4-<2-(1-piperidinyl)ethoxy>phenyl>methanone, elicited a modest uterotropic activity that did not increase with increasing dose.In antagonism of estradiol, 44 exhibited a degree of inhibition surpassing that of tamoxifen at any dose tested.The new benzothiophene antiestrogen was also shown to have high affinity for rat uterine cycloplasmic estrogen receptor and to be an inhibitor of the growth of DMBA-induced rat mammary tumors.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 84449-65-0, and how the biochemistry of the body works.84449-65-0

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem