Cao, Hao-Qiang published the artcileDirect Enamido C(sp2)-H Diphosphorylation Enabled by a PCET-Triggered Double Radical Relay: Access to gem-Bisphosphonates, SDS of cas: 1468-83-3, the main research area is amide unsaturated vinylamide oxidative phosphonylation preparation gem diphosphonate; proton coupled electron transfer enamide phosphonylation radical relay process; unsaturated gem vinylidenediphosphonate amino preparation diphosphonylation enamide silver promoted; bisphosphonates; enamides; radical relay; silver; synthetic methods.
Gem-Diphosphonates ArC(NHCOMe):C[P(O)(OR)2]2 (Ar = substituted Ph, pyridyl, pyrrolyl, thienyl, thiazolyl) were prepared by Ag2O-promoted oxidative diphosphonylation of vinylamides CH2:CArNHCOMe with hydrophosphonates HP(O)(OR)2. Herein we report a novel and straightforward protocol for the construction of valuable gem-BPs by means of proton-coupled electron-transfer (PCET)-triggered enamido C(sp2)-H diphosphorylation. This reaction represents a rare example of realizing the challenging double C-P bond formation at a single carbon atom, thus providing facile access to a broad variety of structurally diverse bisphosphonates from simple enamides under silver-mediated conditions. Initial mechanistic studies demonstrated that the diphosphorylation involves two rounds of PCET-initiated radical relay process.
Chemistry – A European Journal published new progress about C-P bond formation. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, SDS of cas: 1468-83-3.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem