Day: November 11, 2022

Zhao, Jinwu published the artcileMetal-Free Synthesis of Imidazo[2,1-b]thiazoles from Thioimidazoles and Ketones Mediated by Selectfluor, Related Products of benzothiophene, the main research area is imidazole thiazole preparation thioimidazole ketone Selectfluor.

This paper presents a practical and efficient strategy for the preparation of imidazol[2,1-b]-thiazoles from thioimidazoles and ketones mediated by Selectfluor. The proposed mechanism suggests that this transformation took place through electrophilic thiolation at an α-carbon of ketones by sulfur cation, which was produced by the oxidation of thioimidazole by Selectfluor. This metal-free protocol tolerated various ketones, including Me ketones or non-Me ketones, aryl ketones or aliphatic ketones. Steric hindrance of the substituents at the α-position of ketones or on the aromatic ring of aryl ketones had significant influence on the yields of imidazol[2,1-b]-thiazoles. Thioimidazole and benzothioimidazoles were well tolerated while 5-substituted benzothioimidazoles provided the mixture of the corresponding 6-substituted and 7-substituted benzoimidazo[2,1-b]thiazole products.

European Journal of Organic Chemistry published new progress about Aliphatic ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Related Products of benzothiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Sun, Lincong published the artcileRhodium(III)-catalyzed asymmetric [4+1] spiroannulations of O-pivaloyl oximes with α-diazo compounds, COA of Formula: C6H6OS, the main research area is spirocyclic imine preparation enantioselective; pivaloyl oxime diazo homophthalimide spirocyclization rhodium catalyst.

Chiral Rh (III) catalysts can catalyze the asym. [4+1] spiroannulation of O-pivaloyl oximes with α-diazo homophthalimides under redox-neutral and acid/base-neutral conditions, leading to formation of chiral spirocyclic imines as a result of C-H activation and N-O cleavage. The reaction proceeded with high efficiency and features broad substrate scope, mild reaction conditions, and high to excellent enantioselectivities.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cyclic imines Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, COA of Formula: C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Tian, Qing published the artcileSynthesis of quinazolin-4(3H)-ones via electrochemical decarboxylative cyclization of α-keto acids with 2-aminobenzamides, Quality Control of 1468-83-3, the main research area is aryl quinazolinone green preparation; alpha keto acid aminobenzamide electrochem decarboxylative cyclization.

Herein, an environmentally benign electrochem. protocol had been disclosed for the synthesis of quinazolin-4(3H)-one derivatives I [Ar = 3-thienyl, Ph, 2-naphthyl, etc.; R1 = H, 7-F, 7-Cl, 7-Me, 6-Me, 6-MeO; R2 = H, Me, Ph, etc.] from readily available α-keto acids and 2-aminobenzamides. This decarboxylative cyclization process proceeded conveniently in the absence of any homogeneous metal catalysts, bases, or external oxidants. This protocol also featured CO2 byproducts, mild reaction conditions (room temperature and air atm.), and a wide variety of substrate scope, including an array of 2,3-disubstituted quinazolinone products I [Ar = Ph; R1 = H; R2 = n-Bu, iso-Bu, Ph, 2-MeC6H4, Bn, phenethyl].

Molecular Catalysis published new progress about Anhydrides, cyclic Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Quality Control of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Qin, Zemin published the artcileCo(II)-Catalyzed Oxidation of N,N-Dimethylaminoethanol: An Efficient Synthesis of Unsymmetrical (2,4-) and Symmetrical (2,6-) Diarylpyridines through Annulation of Aromatic Ketones with a Nitrogen Source, SDS of cas: 1468-83-3, the main research area is diarylpyridine preparation; aromatic ketone dimethylaminoethanol pseudo multicomponent one pot annulation.

An efficient and facile synthesis of 2,4- and 2,6-diarylpyridines has been developed. It involves one-pot [2+2+1+1] pseudo four-component annulation of aromatic ketones, a nitrogen source and a carbon donor. N,N-Dimethylaminoethanol is oxidized in the presence of Co(II) to provide a carbon synthon. Two C-C and two C-N bonds are formed during the oxidative annulation process. The products are strictly controlled due to the steric hindrance: 2,4-diarylpyridines are afforded effectively with small ketones while 2,6-diaryl analogs predominate when bulky ketones are employed.

Asian Journal of Organic Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, SDS of cas: 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Zhou, You published the artcileI2-Promoted site-selective C-C bond cleavage of aryl methyl ketones as C1 synthons for constructing 5-acyl-1H-pyrazolo[3,4-b]pyridines, Application In Synthesis of 1468-83-3, the main research area is aryl methyl ketone aminopyrazole enaminone iodine cleavage cyclization; pyrazolopyridine regioselective preparation.

A novel iodine promoted [1 + 3 + 2] cleavage cyclization reaction for the synthesis of 1H-pyrazolo[3,4-b]pyridines from aryl Me ketones, 5-aminopyrazoles and enaminones was established. This transition metal-free catalysis method has simple reaction conditions and good substrate compatibility, and was demonstrated in the transformation of alkyl and natural mol.-derived enaminones. Mechanistic studies showed that two cyclization pathways affording different key intermediates were involved, but affording the same target product after site-selective cleavage of the unstrained C-C bond of the acyl group.

Organic Chemistry Frontiers published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Application In Synthesis of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Zhuang, Shi-Yi published the artcileCopper-catalyzed Reaction of Anthranils with Methyl Ketones: Site-Selective C5-Dicarbonylation of Anthranils, Synthetic Route of 1468-83-3, the main research area is diketone preparation regioselective; anthranil aryl methyl ketone dicarbonylation copper catalyst.

A copper-catalyzed site-selective C5-dicarbonylation reaction of 2,1-benzisoxazole has been developed for synthesis of 1,2-dicarbonyl compounds RC(O)C(O)R1 (R = C6H5, 4-FC6H4, 2-thienyl, etc.; R1 = 4-amino-3-formylphenyl) using Me ketones RC(O)Me as a com. available carbonylation reagent. This process represents the first example to implement the C5-dicarbonylation of anthranils, which involves an oxidative Csp3-H/Csp2-H cross-coupling reaction along with thermolytic N-O bond cleavage.

Advanced Synthesis & Catalysis published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Synthetic Route of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Zhuang, Shi-Yi published the artcileCopper-catalyzed Oxidative C(sp3)-H/C(sp3)-H Cross-Coupling Reaction of 3-Methylbenzo[c]isoxazoles with Methyl Ketones: Access to Indigoid Analogues, Product Details of C6H6OS, the main research area is aryl methylketone benzoxazole copper tandem ring opening aza Michael; oxoindolinylidene ketone diastereoselective preparation.

A copper-catalyzed oxidative C(sp3)-H/C(sp3)-H cross-coupling reaction of Me ketones and 3-methylbenzo[c]isoxazoles was developed for the direct synthesis of 3-oxoindolin-2-ylidene derivatives This process involved an intermol. nucleophilic addition/ring-opening/aza-Michael addition cascade, providing indigoid analogs with high atom economy and as single isomers exclusively under mild conditions.

Journal of Organic Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Product Details of C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Yang, Qing published the artcileMerrifield resin-supported quinone as an efficient biomimetic catalyst for metal-free, base-free, chemoselective synthesis of 2,4,6-trisubstituted pyridines, Product Details of C6H6OS, the main research area is pyridine chemoselective synthesis Merrifield resin supported quinone catalyst green.

Metal-free, base-free, biomimetic and chemoselective synthesis of 2,4,6-trisubstituted pyridines was developed under mild conditions for the first time. The heterogeneous biomimetic catalyst – recoverable Merrifield resin-supported quinone – was fully characterized by Fourier transform IR spectroscopy (FT-IR), X-ray photoelectron spectrometry (XPS) and energy dispersive X-ray spectroscopy (EDX). This supported quinone catalyst exhibited excellent catalytic reactivity for chemoselective synthesis of 2,4,6-trisubstituted pyridines, providing an efficient and green method for the synthesis of pyridine derivatives under mild conditions. Mechanistic investigations were conducted to gain insights into the heterogeneous biomimetic catalyst as well as the resulting transformation. The successful capture of intermediates offered direct and clear evidence for the proposed mechanism.

Green Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Product Details of C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Szollosi, Gyoergy published the artcileHighly Enantioselective Transfer Hydrogenation of Prochiral Ketones Using Ru(II)-Chitosan Catalyst in Aqueous Media, HPLC of Formula: 1468-83-3, the main research area is benzylic alc enantioselective preparation; acetophenone cyclic aryl ketone enantioselective transfer hydrogen ruthenium catalyst; chitosan ruthenium complex preparation characterization enantioselective transfer hydrogenation catalyst.

In the presence of a chitosan complex of ruthenium generated either in situ or prepared from [RuCl2(p-cymene)]2 and chitosan, aryl Me ketones and cyclic aryl ketones underwent enantioselective transfer hydrogenation with sodium formate in aqueous isopropanol to yield (S)-benzylic alcs. α-Methylbenzyl alcs. were formed in up to 86% ee, while cyclic and heterocyclic ketones were formed in up to 97% ee; aryl alkyl and alkyl ketones were hydrogenated in lower enantioselectivities. The structure of the chitosan-bound ruthenium catalyst was studied; O-methylation of the catalyst did not yield an improved catalyst.

ChemCatChem published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, HPLC of Formula: 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Ding, Yuxin published the artcileSolvent-dependent metal-free chemoselective synthesis of benzimidazoles and 1,3,5-triarylbenzenes from 2-amino anilines and aryl alkyl ketones catalyzed by I2, Quality Control of 1468-83-3, the main research area is benzimidazole preparation chemoselective; amino aniline aryl alkyl ketone condensation iodine catalyst; triarylbenzene preparation chemoselective; aryl alkyl ketone cyclization iodine catalyst.

A solvent-dependent I2-catalyzed chemoselective reaction was developed for the synthesis of benzimidazoles I (R = H, Cl, Me; R1 = H, Cl, Me; R2 = Ph, 2-naphthyl, 3-thienyl, etc.) and 1,3,5-triarylbenzenes 1,3,5-(Ar)3C6H3 (Ar = Ph, 2-naphthyl, 3-thienyl, etc.) via the annulation of 2-amino anilines 1,2-(NH2)2-4-R-5-R1C6H2 and aryl alkyl ketones R2C(O)Me or the cyclization of aryl alkyl ketones ArC(O)Me, resp. With 1,4-dioxane as the solvent, sequential C-N bond formation followed by C(CO)-C(CH3) bond cleavage leads to the formation of benzimidazoles I in a highly selective manner while aldol-type self-condensation of aryl alkyl ketones predominates using PhNO2 or PhCl as the solvent to afford 1,3,5-triarylbenzenes.

Tetrahedron Letters published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Quality Control of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem