Schlatter, E. published the artcileEffect of “”high ceiling”” diuretics on active salt transport in the cortical thick ascending limb of Henle’s loop of rabbit kidney. Correlation of chemical structure and inhibitory potency, Category: benzothiophene, the main research area is diuretic structure kidney salt transport.
The effects of “”high ceiling”” diuretics on the thick ascending limb of the loop of Henle (TAL) and the effect of structure modification on the inhibitory effect of furosemide (I) [54-31-9] on the Na+-2Cl–K+ cotransport system present in the lumen membrane of the TAL were investigated. Isolated cortical TAL (cTAL) segments of rabbit kidneys were perfused in vitro. The equivalent short-circuit current, as a measure of active salt transport, was correlated to the concentration of 64 substances. The results indicated that the so-called “”high ceiling”” or “”loop”” diuretics consist of at least 3 groups: drugs that do not interfere with the active salt transport in the cTAL segment, drugs that interfere by as-yet-uncharacterized mechanisms, and drugs of the furosemide type which inhibit the Na+-2Cl–K+ cotransport system in the lumen membrane of the cTAL segment.
Pfluegers Archiv published new progress about Biological transport. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Category: benzothiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem