Kerremans, A. L. M. published the artcilePharmacokinetic and pharmacodynamic studies of tienilic acid in healthy volunteers, Category: benzothiophene, the main research area is tienilic acid pharmacokinetics pharmacodynamics.
In 8 healthy adult volunteers the plasma and urinary levels of tienilic acid and its alc. metabolite, and plasma and urinary levels of Na, creatinine [60-27-5] and uric acid [69-93-2] were measured after oral administration of tienilic acid (I) [40180-04-9] 250 mg. A high-performance liquid chromatog. method was developed for the determination of I and its metabolite in plasma and urine. The pharmacokinetic parameters differed only slightly from those reported in the literature, as there was faster absorption and a shorter half-life. I was probably excreted by a saturable renal tubular transport mechanism. The pharmacodynamic effects of tienilic acid developed quickly, showing a uricosuric effect and a moderate natriuretic effect. These effects disappeared in about 8 h. An inverse relationship was found between the starting plasma uric acid level in an individual and the maximal uric acid clearance: the higher the plasma uric acid level, the lower was the maximum effect. Correlation between plasma tienilic acid level and natriuretic effect were seen within individuals and intraindividually. Urinary tienilic acid levels and natriuretic effect were also correlated but only intraindividually. No correlation between drug level and uricosuric effect was found.
European Journal of Clinical Pharmacology published new progress about Blood analysis. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Category: benzothiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem