Day: November 22, 2022

Formation mechanism of aroma compounds in a glutathione-glucose reaction with fat or oxidized fat was written by Zhao, Jian;Wang, Tianze;Xie, Jianchun;Xiao, Qunfei;Cheng, Jie;Chen, Feng;Wang, Shi;Sun, Baoguo. And the article was included in Food Chemistry in 2019.Electric Literature of C6H8S The following contents are mentioned in the article:

Glutathione and glucose with or without chicken fat/oxidized chicken fat were thermally reacted for generation of stewed meat-like aroma, where 42 sulfur-containing odorants were identified by gas chromatog.-mass spectrometry (GC-MS) and gas chromatog.-olfactometry (GC-O). The observed effects or interactions on meat flavor formation due to the fats were similar to previous reports of cysteine-reducing sugar reactions. Carbohydrate module labeling approach demonstrated ten alkyl chain compounds were indeed resulted from the lipid degradation-Maillard reaction interactions, whereas the fats had little effect on formation pathways of compounds only derived from the Maillard reaction. Formation pathways of 26 potent aroma compounds were proposed, particularly, involving two benzene derivatives and seven complex thiophenes. Notably, it was found for the first time just 2-ethylthiophene could result from both an intact skeleton of glucose and the lipid degradation product of 2,4-hexadienal, and the carbohydrate modules methylglyoxal and hydroxyacetone could arise from the glutamic acid of GSH. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Electric Literature of C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Electric Literature of C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Metabolomics Approaches for Analyzing Effects of Geographic and Environmental Factors on the Variation of Root Essential Oils of Ferula assa-foetida L was written by Karimi, Ali;Kraehmer, Andrea;Herwig, Nadine;Hadian, Javad;Schulz, Hartwig;Meiners, Torsten. And the article was included in Journal of Agricultural and Food Chemistry in 2020.HPLC of Formula: 638-02-8 The following contents are mentioned in the article:

Environmental factors shape the production and accumulation processes of plant secondary metabolites in medical and aromatic plants and thus their pharmacol. and biol. activity. Using an environmental metabolomics approach, we determined chemotypes and specific compounds on the basis of essential oils (EOs) from roots of 10 Iranian Ferula assa-foetida L. populations and related them to geog., climate, and edaphic data. GC-MS revealed three distinct chemotypes characterized by (I) monoterpenes and Z-1-propenyl sec-Bu disulfide; (II) eudesmane sesquiterpenoids and α-agarofuran; and (III) Z- and E-1-propenyl sec-Bu disulfide. NIRS measurements indicated a similar but less distinct pattern. Structural equation models showed that EO constituents and content were directly influenced by edaphic factors (texture, pH, and iron, potassium, and aluminum content) and temperature and predominantly indirectly by latitude, longitude, and altitude. Predicting EO constituents or chemotypes by geog., climate, and soil factors can be used in F. assa-foetida to select populations with specific EO characteristics. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8HPLC of Formula: 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.HPLC of Formula: 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis, Cytotoxic Activity and Molecular Docking Studies of New Condensed Thieno[2,3-d]Pyrimidines as Antitumor Agents was written by Kaliraj, S.;Jeyalakshmi, R.;Kathiravan, M. K.. And the article was included in Pharmaceutical Chemistry Journal in 2020.Reference of 95211-67-9 The following contents are mentioned in the article:

A series of lactam fused thienopyrimidines I [R¹ = H, Me, Et, CO₂Me, etc.; R² = H, Me; R¹R² = (CH₂)₄, (CH₂)₃CH(Me); n = 1, 2, 3] and triazole fused thienopyrimidines II [R¹ = H, Me, CO₂Et, etc.; R² = H, Me, Ph; R³ = Me, 4-OHC₆H₄; R¹R² = (CH₂)₃, (CH₂)₄, (CH₂)₃CH(Me)] were synthesized. The target compounds were obtained in good yield and confirmed for their structural integrity. The cytotoxic activity against A431 human epidermoid carcinoma and H9c2 rat cardiomyocyte cells were studied by MTT assay. Most of the synthesized compounds showed 85% cell death in both human A341 and rat H9c2 cell lines, indicating potential anticancer activity of these compounds Interestingly, compound II [R³ = 4-OHC₆H₄] showed a reversal in trend by enhancing the growth of both A341 and H9c2 cells. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Reference of 95211-67-9).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Reference of 95211-67-9

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Synthesis and complexation behavior of 3,4-bis(chloromercurio)2,5-dimethylthiophene was written by Sa, Shreenibasa;Sathesh, Venkatesan;Murali, Anna Chandrasekar;Nayak, Prakash;Venkatasubbaiah, Krishnan. And the article was included in Journal of Organometallic Chemistry in 2021.Synthetic Route of C6H8S The following contents are mentioned in the article:

Synthesis of a new bidentate Lewis acid 3,4-bis(chloromercurio)2,5-dimethylthiophene (1) has been reported which is not accessible using other methods. Crystallization of compound 1 from a THF (THF) and DMSO (DMSO) results Lewis acid-nucleophile (Lewis base) adduct in 1:2 ratio such as C₆H₆SHg₂Cl₂•2THF (2) & C₆H₆SHg₂Cl₂•2DMSO (3) resp. The bifunctional Lewis acid on crystallization with Et₄NCl resulted in the formation of compound 4 {[(C₆H₆SHg₂Cl₂)₃Cl₂][Et₄N]₂}, which is a unique 3:2 adduct of compound 1 with chloride anion. Compounds 1–4 have been characterized by NMR, elemental anal., and X-ray crystallog. The solid state structures of compounds 1–4 reveals the existence of Hg•••Cl, C-H•••Cl weak interactions which lead to the formation of 1D, 2D and 3D supramol. structures. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Synthetic Route of C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Synthetic Route of C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Analysis of pyrolysis liquids obtained from the slow pyrolysis of a German brown coal by comprehensive gas chromatography mass spectrometry was written by Rathsack, Philipp. And the article was included in Fuel in 2017.Product Details of 638-02-8 The following contents are mentioned in the article:

Due to the upcoming shortage of crude oil and natural gas, alternative resources for the production of chems. are needed and long-term research should be conducted. One of the future possible methods for the production of valuable chems. is the use of coal and its conversion by pyrolysis. During pyrolysis, macromol. organic compounds are decomposed into smaller compounds, which can be used. The development of these processes requires compositional knowledge of the products, which are very complex mixtures of organic compounds Pyrolysis liquids obtained in a fixed bed reactor at different pyrolysis temperatures between 400 and 700° is analyzed qual. and quant. by comprehensive gas chromatog. mass spectrometry (GC×GC-MS). More than thousand compounds were observed in each of the samples. Selected compound classes (alkanes, alkenes, alkylbenzenes, phenols, carboxylic acids and thiophenes) are discussed. Quantification results of 94 compounds are given, visualized and discussed in relation to the pyrolysis conditions. It is demonstrated, that the application of GC×GC-MS is highly beneficial for the anal. of pyrolysis liquids from coal. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Product Details of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. The different substitution patterns in these heterocycles offer new opportunities for drug discovery and other applications in materials science.Product Details of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Elicitation of organosulfur bioactive compounds with Fe³⁺ and Zn²⁺ in cell suspension culture of single garlic (Allium sativum L.) was written by Setiowati, Frida Kunti;Widoretno, Wahyu;Prasetyawan, Sasangka;Lukiati, Betty. And the article was included in Farmacia (Bucharest, Romania) in 2022.Application of 638-02-8 The following contents are mentioned in the article:

Single garlic (Allium sativum L.) is an herbal plant that is rich in organosulfur compounds and widely used for the treatment in health problems such as high blood pressure, hypercholesterolemia, atherosclerosis and cancer. This study aims to investigate the different concentrations effect of Fe³⁺ and Zn²⁺ elicitor (0, 0.1, 0.2, 0.3, 0.4, 0.5 mM, resp.) in single garlic cell suspension culture. The formation of suspension culture was done by culturing the callus in Murashige and Skoog liquid medium. The HPLC anal. revealed the presence of 30 organosulfur compounds The Fe³⁺ and Zn²⁺ elicitors can increase the growth of cell suspension culture and production of organosulfur compounds The highest of fresh weight, dry weight, settled cell volume, growth index were produced in the medium augmented by 0.5 mM Fe³⁺ and 0.5 mM Zn²⁺, while organosulfur compounds increase with 0.3 mM Zn²⁺ (2-fold) and 0.5 mM Fe³⁺ (1.5-fold). The Fe³⁺ and Zn²⁺ metal ions are effective elicitors to increase the production of organosulfur bioactive compounds This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Application of 638-02-8).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Application of 638-02-8

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Characterization of typical potent odorants in raw and cooked Toona sinensis (A. Juss.) M. Roem. by instrumental-sensory analysis techniques was written by Yang, Wenxi;Cadwallader, Keith R.;Liu, Yuping;Huang, Mingquan;Sun, Baoguo. And the article was included in Food Chemistry in 2019.Computed Properties of C6H8S The following contents are mentioned in the article:

Toona sinensis (A. Juss.) M. Roem. (TS) possesses a unique and pleasant flavor and is consumed as a popular seasonal vegetable in certain parts of eastern and southeastern Asia. The potent odorants in raw and cooked TS were identified by combined sensory and instrumental anal. techniques, including sensory descriptive aroma profiling and two complimentary volatile isolation methods combined with gas chromatog.-olfactometry (GC-O) techniques. Highly volatile odorants were determined by static headspace dilution anal. (SHDA)-GC-O, while those of intermediate- and semi-volatility were determined by solvent-assisted flavor evaporation-aroma extract dilution anal. (SAFE-AEDA). Among the numerous odorants identified by SHDA and SAFE-AEDA, (E,E)-bis-(1-propenyl) disulfide was found to be predominant in both raw and cooked TS. In agreement with results of sensory descriptive anal., hexanal, (Z)-3-hexenal, (E)-2-hexenal and (Z)-3-hexen-1-ol contributed green, grassy and leafy aroma notes; while hydrogen sulfide, Me thiirane, (E,E)-bis-(1-propenyl) disulfide and (E,Z)-bis-(1-propenyl) disulfide contributed pungent, sulfurous and alliaceous notes in TS. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Computed Properties of C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. It is also used in the manufacturing of dyes such as thioindigo.Computed Properties of C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

PEG/PVDF membranes for separating organosulphur compounds from N-heptane: Effect pf PEG molecular weight was written by Hu, Wenling;Han, Xiaolong;Liu, Liangliang;Zhang, Xin;Xue, Juanqin;Wang, Baoyi;Zhang, Peng;Cao, Xingzhong. And the article was included in Canadian Journal of Chemical Engineering in 2017.Formula: C6H8S The following contents are mentioned in the article:

Polyethylene glycol (PEG) of three different mol. weights were used to prepared PEG/PVDF composite membranes for separating organosulphur compounds from n-heptane by pervaporation. All the composite membranes were characterized by Fourier transform IR spectroscopy (FTIR), SEM (SEM) X-ray diffraction (XRD) and positron annihilation spectroscopy (PAS). The effects of operating temperature, feed sulfur content and organosulphur species on performance of PEG/PVDF composite membranes with different mol. weights were investigated. When the feed organosulphur was thiophene, the fluxes decreased with an increase in PEG mol. weights, however, the enrichment factors were in the different order, PEG membrane with mol. weight of 35 000 exhibited highest enrichment factor of 12.59 for thiophene at 85 °C. When the feed organosulphur was 2-Methylthiophene or 2, 5-Dimethylthiophene, it was found that PEG membrane with mol. weight of 100 000 showed highest enrichment factor. The results showed that PEG mol. weights have a considerable effect on separation performance for pervaporation desulphurization. This article is protected by copyright. All rights reserved. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Formula: C6H8S).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Formula: C6H8S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors was written by Zhang, Xin;Zhou, Xilin;Kisliuk, Roy L.;Piraino, Jennifer;Cody, Vivian;Gangjee, Aleem. And the article was included in Bioorganic & Medicinal Chemistry in 2011.Formula: C12H17NO2S The following contents are mentioned in the article:

Classical antifolates (4-7) with a tricyclic benzo[4,5]thieno[2,3-d]pyrimidine scaffold and a flexible and rigid benzoylglutamate were synthesized as dual thymidylate synthase (TS) and dihydrofolate reductase (DHFR) inhibitors. Oxidative aromatization of Et 2-amino-4-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate (±)-9 to Et 2-amino-4-methyl-1-benzothiophene-3-carboxylate 10 with 10% Pd/C was a key synthetic step. Compounds with 2-CH₃ substituents inhibited human (h) TS (IC₅₀ = 0.26-0.8 μM), but not hDHFR. Substitution of the 2-CH₃ with a 2-NH₂ increases hTS inhibition by more than 10-fold and also affords excellent hDHFR inhibition (IC₅₀ = 0.09-0.1 μM). This study shows that the tricyclic benzo[4,5]thieno[2,3-d]pyrimidine scaffold is highly conducive to single hTS or dual hTS-hDHFR inhibition depending on the 2-position substituents. The X-ray crystal structures of 6 and 7 (I) with hDHFR reveal, for the first time, that tricyclics 6 and 7 bind with the benzo[4,5]thieno[2,3-d]pyrimidine ring in the folate binding mode with the thieno S mimicking the 4-amino of methotrexate. This study involved multiple reactions and reactants, such as Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9Formula: C12H17NO2S).

Ethyl 2-amino-4-methyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (cas: 95211-67-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Formula: C12H17NO2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Chemoselective Catalytic Dehydrogenative Cross-Coupling of 2-Acylimidazoles: Mechanistic Investigations and Synthetic Scope was written by Tanaka, Tsukushi;Hashiguchi, Kayoko;Tanaka, Takafumi;Yazaki, Ryo;Ohshima, Takashi. And the article was included in ACS Catalysis in 2018.Application In Synthesis of 2,5-Dimethylthiophene The following contents are mentioned in the article:

Chemoselective iron-catalyzed dehydrogenative cross-coupling using 2-acylimidazoles is described. The addition of a phosphine oxide ligand substantially facilitated the generation of tert-butoxy radicals from di-tert-Bu peroxide, allowing for efficient benzylic C-H bond cleavage under mild conditions. Extensive mechanistic studies revealed that the enolization of 2-acylimidazole proceeded through dual iron catalyst activation, followed by subsequent chemoselective cross-coupling with a benzyl radical over an undesired benzyl radical-derived homocoupling dimer that inevitably formed in earlier reported conditions. A variety of alkylarenes, aliphatic alkane, and functionalized 2-acylimidazoles were applicable, demonstrating the synthetic utility of the present catalysis. Contiguous all-carbon quaternary carbons were constructed through dehydrogenative cross-coupling. The catalytic chemoselective activation of 2-acylimidazole over bidentate coordinative and much more acidic malonate diester was particular noteworthy. Catalytic oxidative cross-enolate coupling of two distinct carboxylic acid equivalent was also achieved using acetonitrile as a coupling partner. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Application In Synthesis of 2,5-Dimethylthiophene).

2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Application In Synthesis of 2,5-Dimethylthiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem