Beaune, Philippe published the artcileAutoantibodies to cytochrome P-450 during autoimmune hepatitis, Related Products of benzothiophene, the main research area is tienilic acid hepatitis autoantibody cytochrome P450; liver kidney microsome autoantibody drug hepatitis; autoimmune hepatitis autoantibody cytochrome.
Anti-liver/kidney microsomes (anti-LKM) autoantibodies have been found in the serum of patients suffering from different kinds of hepatitis including tienilic acid-induced hepatitis. These autoantibodies were used to study the nature of the macromol. that they recognized. By using immunoblot and immunoinhibition techniques it was shown that these autoantibodies recognized specifically human cytochrome P 450-8 (= P-450 MP or P 450-II C9); this cytochrome P-450 is also responsible for the oxidation of tienilic acid and mephenytoin and produced a reactive metabolite covalently bound to proteins. A simple scheme describing some of the steps leading to the disease is proposed. The study of other autoantibodies seems to show that the scheme which is proposed is rather general.
Colloque INSERM published new progress about Autoantibodies Role: BIOL (Biological Study). 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Related Products of benzothiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem