Luo, Wenjun published the artcileSynthesis of W-Phos Ligand and Its Application in the Copper-Catalyzed Enantioselective Addition of Linear Grignard Reagents to Ketones, SDS of cas: 1468-83-3, the main research area is ketone Grignard reagent copper phosphine enantioselective regioselective addition; chiral tertiary alc preparation; Alcohols; Asymmetric Catalysis; Copper; Grignard Reagents; Ketones.
A novel family of PNP ligands (W-Phos) was designed and applied in copper-catalyzed asym. addition of linear Grignard reagents to aryl alkyl ketones, allowing facile access to versatile chiral tertiary alcs. in good to high yields with excellent enantioselectivities (up to 94% yield, 96% ee). The process was also used to synthesize chiral allylic tertiary alcs. from more challenging α,β-unsaturated ketones. Notably, the potential utility of this method was demonstrated in the gram-scale synthesis and modification of various densely functionalized medicinally relevant mols.
Angewandte Chemie, International Edition published new progress about Addition reaction catalysts, regioselective. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, SDS of cas: 1468-83-3.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem