Shin, Soon Young published the artcileDesign, synthesis, and biological activities of 1-aryl-(3-(2-styryl)phenyl)prop-2-en-1-ones, Formula: C6H6OS, the main research area is arylstyrylphenylpropenone synthesis antitumor apoptosis ROS; 1-aryl-(3-(2-styryl)phenyl)prop-2-en-1-one; Apoptosis; CoMFA; CoMSIA; Poly(ADP-ribose) polymerase; ROS generation.
A moderate elevation in reactive oxygen species (ROS) levels can generally be controlled in normal cells, but may lead to death of cancer cells as the ROS level in cancer cells is already elevated. Therefore, a ROS-generating compound can act as a selective chemotherapeutic agent for cancer cells that does not affect normal cells. In our previous study, a compound containing a Michael acceptor was selectively cytotoxic to cancer cells without affecting normal cells; therefore, we designed and synthesized 26 compounds containing a Michael acceptor. Their cytotoxicities against HCT116 human colon cancer cell lines were measured by using a clonogenic long-term survival assay. To derive the structural conditions required to obtain stronger cytotoxicity against cancer cells, the relationships between the half-maximal cell growth inhibitory concentration values of the synthesized compounds and their physicochem. properties were evaluated by Comparative Mol. Field Anal. and Comparative Mol. Similarity Indexes Anal. It was confirmed that the compound with the best half-maximal cell growth inhibitory concentration triggered apoptosis through ROS generation, which then led to stimulation of the caspase pathway.
Bioorganic Chemistry published new progress about Antitumor agents. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Formula: C6H6OS.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem