Stueber, Wolfgang published the artcileDetermination of ethacrynic and tienilic acid in plasma by gas-liquid chromatography-mass spectrometry, Name: 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, the main research area is ethacrynate tienilate determination blood; gas chromatog ethacrynate tienilate; mass spectrometry ethacrynate tienilate.
ethacrynic acid (I) [58-54-8] and tienilic acid (II) [40180-04-9] were extracted from plasma with (Et)2O. I and II were derivatized with pentafluorobenzyl bromide before being subjected to gas chromatog. on a column packed with 1% OV-17 on Chromosorb W, 80-100 mesh, with He as the carrier gas and the column temperature increasing from 200 to 300° at 30°/min. Using mass spectrometry in the electron-impact mode, detection of the mol. ion peak was possible for both I and II (m/e = 511 and 483, resp.). The recoveries of I and II were 94.5 and 95%, resp. Linear regression of the calibration graph gave a value of 0.998 for 0.5-1μg/mL and the limit of detection was ∼10-20 ng/mL plasma.
Journal of Chromatography, Biomedical Applications published new progress about Blood analysis. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Name: 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem