Category: benzothiophene

Dolan, Martin A. published the artcileCatalytic Nanoassemblies Formed by Short Peptides Promote Highly Enantioselective Transfer Hydrogenation, Formula: C6H6OS, the main research area is short peptide catalytic nanoassembly enantioselective transfer hydrogenation; ATH; catalysis; enantioselective; micelle; peptide; self-assembly; vesicle.

Self-assembly enables formation of incredibly diverse supramol. structures with practically important functions from simple and inexpensive building blocks. Here, we show how a semirational, bottom-up approach to create emerging properties can be extended to a design of highly enantioselective catalytic nanoassemblies. The designed peptides comprising as few as two amino acid residues spontaneously self-assemble in the presence of metal ions to form supramol., vesicle-like nanoassemblies that promote transfer hydrogenation of ketones in an aqueous phase with excellent conversion rates and enantioselectivities (>90% ee).

ACS Nano published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Formula: C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Chan, Chieh-Kai published the artcileAcid-controlled multicomponent selective synthesis of 2,4,6-triaryl pyridines and pyrimidines by using hexamethyldisilazane as a nitrogen source under microwave irradiation, HPLC of Formula: 1468-83-3, the main research area is triaryl pyridine pyrimidine preparation; acetophenone benzaldehyde microwave irradiation multi component reaction.

An efficient and general protocol for the synthesis of functionalized 2,4,6-triaryl pyridines and pyrimidines was developed from com. available aromatic ketones, aldehydes and hexamethyldisilazane (HMDS) as a nitrogen source under microwave irradiation In this multicomponent synthetic route, Lewis acids play an important role in selectively synthesizing six-membered heterocycles, including pyridines (1N) and pyrimidines (2N), by involving [2 + 1 + 2 + 1] or [2 + 1 + 1 + 1 + 1] annulated processes.

RSC Advances published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, HPLC of Formula: 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Dattatri published the artcileCu-Catalyzed tandem cyclization and coupling of enynones with enaminones for multisubstituted furans & furano-pyrroles, Recommanded Product: 3-Acetylthiophene, the main research area is furan furano pyrrole preparation; enynone enaminone coupling tandem cyclization copper.

A synthetic strategy that efficiently constructs complex mol. diversity in a few steps will always be embraced by organic chemists. Here, authors report a cascade reaction of enynones with enaminones via carbene insertion and aryl migration to engineer distinctive multisubstituted furans with an all-carbon quaternary center, and could extend the protocol in the same pot towards furano-pyrrole bis-heterocycles. Heterogeneity of this protocol was proved with the upshot of divergent chem. space under a relatively mild reaction environment.

Organic & Biomolecular Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Zhao, Peng published the artcileIodine-Promoted Multicomponent Synthesis of 2,4-Diamino-1,3,5-triazines, Quality Control of 1468-83-3, the main research area is methyl ketone cyanamide arylamine cyclization iodine multicomponent amination; diamino triazine preparation.

A novel and efficient multicomponent cyclization of Me ketones, cyanamides, and arylamines for the synthesizing 2,4-diamino-1,3,5-triazines via consecutive formation of four C-N bonds is reported. This multicomponent reaction is characterized by the employment of two mols. of cyanamide for double C(sp3)-H amination of Me ketones, avoiding complicated preparation of substrates and expanding the substrate scope. Furthermore, this multicomponent cyclization strategy provides a new approach for generating diverse 2,4-diamino-1,3,5-triazines with a broad substrate scope under mild conditions.

Organic Letters published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Quality Control of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Jiang, Jingjing published the artcileThree-component synthesis of 1,4-benzothiazines via iodide-catalyzed aerobic C-H sulfuration with elemental sulfur, Synthetic Route of 1468-83-3, the main research area is benzothiazine preparation green chem diastereoselective; acetophenone aniline sulfur three component sulfuration iodide catalyst.

Herein, iodide-catalyzed aerobic synthesis of 1,4-benzothiazines via functionalization of multiple C-H bonds with elemental sulfur is described. Beyond the well-established thiazole formation from elemental sulfur, this method provides the first access to the corresponding six-membered N,S-heterocyclic products via direct functionalization of multiple C-H bonds. Hence, 1,4-benzothiazine products were generated in satisfactory yields with a range of compatible functionalities.

Organic & Biomolecular Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Synthetic Route of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Geng, Xiao published the artcileIodine-Promoted N-H/α,β-C(sp3)-Trifunctionalization of L-Proline: Access to 3,4-Dihydrobenzo[b][1,7]naphthyridines via Consecutive Decarboxylation/Ring Opening/Dicyclization, Quality Control of 1468-83-3, the main research area is iodine trifunctionalization proline; consecutive decarboxylation ring opening dicyclization; dihydrobenzonaphthyridine preparation green chem.

A N-H/α,β-C(sp3)-trifunctionalization of L-proline, proceeding through an iodine-promoted consecutive decarboxylation/ring-opening/dicyclization process, is achieved. This strategy affords structurally diverse fused N-heterocycles in good yields with a wide substrate scope. Preliminary mechanistic studies indicate that catabolism of L-proline might be involved in this cascade reaction and the in situ generated intermediate 4-aminobutanal was identified as the key intermediate. Notably, this domino strategy enriches the reactivity of versatile L-proline in the synthesis of fused heterocycles.

Organic Letters published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Quality Control of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Nayak, Soukhyarani G. published the artcileNovel pyrazole-clubbed thiophene derivatives via Gewald synthesis as antibacterial and anti-inflammatory agents, Product Details of C6H6OS, the main research area is pyrazolyl thiophene carbonitrile Schiff base preparation antibacterial antiinflammatory antitubercular; Gewald reaction; Schiff bases; anti-inflammatory; antimicrobial; antitubercular.

The aim of this study was to synthesize newer potent Schiff bases I (R = H, Cl; Ar = 4-fluorophenyl, 3-bromophenyl, 3-thienyl, etc.) by condensing 2-amino-5-(2,4-dichlorophenyl)thiophene-3-carbonitrile and 1,3-disubstituted-1H-pyrazole-4-carbaldehydes II, and to investigate their biol. activity. The compounds I were synthesized via Gewald synthesis and characterized by spectral data and elemental analyses. They were screened for their in vitro antibacterial and anti-inflammatory activities. The synthesized compounds I were also evaluated for in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv using the microplate Alamar Blue assay. Compounds I (R = H, Ar = 4-chlorophenyl; R = H, Ar = 4-fluorophenyl; R = H, Ar = 4-methoxyphenyl; R = H, Ar = 4-methylphenyl; R = Cl, Ar = 4-fluorophenyl; R = Cl, Ar = 4-methoxyphenyl; R = Cl, Ar = 4-methylphenyl) showed promising antibacterial activity. The interactions between the substituted pyrazoles and bovine protein showed promising anti-inflammatory activity. The exptl. results revealed compound I (R = H; Ar = Ph) as a promising antitubercular agent. Hemolytic assays confirmed that the compounds are nontoxic, with percentage hemolysis ranging from 3.6 to 20.1, at a concentration of 1 mg/mL. The results suggest that the pyrazole ring and the substitution pattern on the heterocyclic moiety I have an effect on the bioactivity.

Archiv der Pharmazie (Weinheim, Germany) published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Product Details of C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Antenucci, Achille published the artcileIron(III)-Catalyzed Hydration of Unactivated Internal Alkynes in Weak Acidic Medium, under Lewis Acid-Assisted Bronsted Acid Catalysis, HPLC of Formula: 1468-83-3, the main research area is arylketone preparation regioselective; internal alkyne hydration iron Lewis Bronsted acid catalyst.

Alkylarylalkynes, e.g., I are converted with full regioselectivity into the corresponding arylketones, e.g., II by formal hydration of the triple bond under weak acidic conditions, at times and temperatures (â‰?5 °C) comparable to those used for terminal alkynes. The process catalyzed by Fe2(SO4)3nH2O in glacial acetic acid exhibits good functional group compatibility, including that with bulky triple bond substituents, and can be extended to the one-pot transformation of aryltrimethylsilylacetylenes ArCCSi(CH3)3 (Ar = thiophen-3-yl, 3,5-(OCH3)2C6H3, 3-F3CC6H4) into acetyl derivatives ArC(O)CH3 via a desilylation-hydration sequence. The overall reactivity pattern along with proton affinity data indicate that the triple bond is activated by proton transfer rather than by π-interaction with the metal ion. This mechanistic feature, at variance with that of noble metal catalysts, accounts for the total regioselectivity and the insensitivity to steric hindrance exhibited by the Fe2(SO4)3nH2O/AcOH catalytic system.

Advanced Synthesis & Catalysis published new progress about Alkyl aryl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, HPLC of Formula: 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Aukland, Miles H. published the artcileMetal-free photoredox-catalysed formal C-H/C-H coupling of arenes enabled by interrupted Pummerer activation, Computed Properties of 1468-83-3, the main research area is arene heteroarene dibenzothiophene oxide photocatalyst regioselective cross coupling reaction; heterobiaryl preparation.

An expedient, one-pot assembly of (hetero)biaryl motifs using photocatalysis and two non-prefunctionalized arene partners was reported. The approach was underpinned by the functionalization of a C-H bond in an arene coupling partner using the interrupted Pummerer reaction. A unique pairing of the organic photoredox catalyst and the intermediate dibenzothiophenium salts enables highly selective reduction in the presence of sensitive functionalities. The utility of the metal-free, one-pot strategy was exemplified by the synthesis of a bioactive natural product and the modification of complex mols. of societal importance.

Nature Catalysis published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Computed Properties of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Zhao, Yue published the artcilePhotochemical (Hetero-)Arylation of Aryl Sulfonium Salts, Name: 3-Acetylthiophene, the main research area is aryl thianthrenium salt heteroarene light photochem arylation; heterobiaryl preparation.

The construction of (hetero)biaryls, which are ubiquitous scaffolds among medical substances, functional materials, and agrochems., constitutes a key application of cross-coupling methods. However, these usually require multiple synthetic steps. Herein, we report a simple photoinduced and catalyst-free C-H/C-H (hetero)arylation cross-coupling through aryl thianthrenium salts, which are formed site-selectively by direct C-H functionalization. The key to this approach is the UV-light, which can disrupt the C-S bond to form thianthrene radical cations and aryl radicals.

Organic Letters published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Name: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem