Antenucci, Achille published the artcileIron(III)-Catalyzed Hydration of Unactivated Internal Alkynes in Weak Acidic Medium, under Lewis Acid-Assisted Bronsted Acid Catalysis, HPLC of Formula: 1468-83-3, the main research area is arylketone preparation regioselective; internal alkyne hydration iron Lewis Bronsted acid catalyst.
Alkylarylalkynes, e.g., I are converted with full regioselectivity into the corresponding arylketones, e.g., II by formal hydration of the triple bond under weak acidic conditions, at times and temperatures (â?5 °C) comparable to those used for terminal alkynes. The process catalyzed by Fe2(SO4)3nH2O in glacial acetic acid exhibits good functional group compatibility, including that with bulky triple bond substituents, and can be extended to the one-pot transformation of aryltrimethylsilylacetylenes ArCCSi(CH3)3 (Ar = thiophen-3-yl, 3,5-(OCH3)2C6H3, 3-F3CC6H4) into acetyl derivatives ArC(O)CH3 via a desilylation-hydration sequence. The overall reactivity pattern along with proton affinity data indicate that the triple bond is activated by proton transfer rather than by Ï-interaction with the metal ion. This mechanistic feature, at variance with that of noble metal catalysts, accounts for the total regioselectivity and the insensitivity to steric hindrance exhibited by the Fe2(SO4)3nH2O/AcOH catalytic system.
Advanced Synthesis & Catalysis published new progress about Alkyl aryl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, HPLC of Formula: 1468-83-3.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem