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20532-28-9, Name is 5-Aminobenzothiophene, belongs to benzothiophene compound, is a common compound. SDS of cas: 20532-28-9In an article, once mentioned the new application about 20532-28-9.

Consecutive intermolecular reductive hydroamination: Cooperative transition-metal and chiral Br¡ãnsted acid catalysis

Enantiomerically pure chiral amines are of increasing importance and commercial value in the fine chemical, pharmaceutical, and agrochemical industries. Here, we describe the straightforward synthesis of chiral amines by combining the atom-economic and environmentally friendly hydroamination of alkynes with an enantioselective hydrogenation of in situ generated imines by using inexpensive hydrogen. By following this novel approach, a wide range of terminal alkynes can be reductively hydroaminated with primary amines including alkyl-, and arylalkynes as well as aryl and heteroaryl amines. Excellent yields and selectivities up to 94 % ee and 96 % isolated yield were obtained.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Some scientific research about Benzo[b]thiophen-5-ol

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O -Difluorodeuteromethylation of phenols using difluorocarbene precursors and deuterium oxide

The first O-difluorodeuteromethylation of phenols using commercial diethyl bromodifluoromethylphosphonate and deuterium oxide to prepare various difluorodeuteromethyl aryl ethers is reported. This facile method affords a convenient way to introduce OCF2D groups into organic molecules.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Some scientific research about 16587-47-6

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Heterocyclic thromboxane synthetase inhibitors and pharmaceutical compositions containing them

Heterocyclic thromboxane synthetase inhibitors of the formula STR1 wherein R1, which is attached to the 2-, 3- or 4-position, is hydrogen, halogen, C1 -C4 alkyl, hydroxy or C1 -C4 alkoxy; Y, which is attached to the 2- or 3-position, is –COOH, –COO(C1 -C4 alkyl) or –CONH2 ; X is O, S, NH, N(C1 -C4 alkyl) or N(benzyl); and R, which is attached to the 5-, 6- or 7-position, is a group of the formula STR2 or (3- or 4-pyridyl)-Z2 – wherein Z1 is –CH2 –, –CH2 CH2 — or –CH2 CH2 O– and Z2 is –CH2 –, –CH2 CH2 –, –CH=CH–, –CH2 O– or –OCH2 –; and their pharmaceutically acceptable salts; processes for their preparation, and pharmaceutical compositions containing them.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

New explortion of 14315-11-8

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An improved synthesis of substituted benzo[b]thiophenes using microwave irradiation

An easy and high-yielding method for the synthesis of substituted benzo[b]thiophenes using microwave irradiation is described.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Brief introduction of Benzo[b]thiophen-5-ol

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Benzothiophene derivative compounds process of preparation and use thereof

This invention provides new benzothiophene derivatives of general formula (I) and a process for preparing them, the corresponding compositions and their use for manufacturing a medicine for the treatment of neurological disorders. These new compounds behave as serotonin reuptake inhibitors and show high affinity towards the 5-HT1A receptor.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Properties and Exciting Facts About 4-Chlorobenzo[b]thiophene

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Related Products of 66490-33-3, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 66490-33-3, molcular formula is C8H5ClS, introducing its new discovery.

Substituted oxoazaheterocyclyl compounds

This invention is directed to oxoazaheterocycyl compounds which inhibit Factor Xa, to oxoazaheterocycyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa..

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Awesome and Easy Science Experiments about 20532-28-9

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: 5-Aminobenzothiophene, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 20532-28-9, in my other articles.

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ACTIVATORS OF THE RETINOIC ACID INDUCIBLE GENE “RIG-I’ PATHWAY AND METHODS OF USE THEREOF

The present invention is directed to compounds of Formula (I), which are activators of the RIG-I pathway.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Properties and Exciting Facts About Benzo[b]thiophen-4-amine

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One method for the preparation of new […] (by machine translation)

The present invention provides a new method for preparing according to […], which belongs to the technical field of pharmaceutical and chemical synthesis. It solves the problem that the existing according to[…] of the preparation method of the impurity is high, the yield is low, the problem of serious pollution. This method, in order to 4-hydroxybenzene and thiophene as the starting material 4 is prepared by the step of reaction intermediates V, to 7-hydroxy-2-quinolone by 2 VII is prepared by the step of reaction intermediates, intermediate V and intermediates prepared by condensation VII clinical medicine […]according to. The raw materials of this invention is easy to obtain, the price is low, the operation is simple, mild reaction conditions, has excellent industrial application value. (by machine translation)

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Extended knowledge of 6386-80-7

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Studies on cognitive enhancing agents. III. Antiamnestic and antihypoxic activities of a series of 1-bicycloaryl-2-(omega-aminoalkoxy)ethanols

2-(2-Aminoethoxy)-1-hydroxyethyl derivatives of bicyclic arenes (naphthalene, thianaphthene, benzofuran, and indole) were prepared and screened for antiamnestic (AA) and antihypoxic (AH) activities which were evaluated by measuring the reversing potency in electroconvulsion-induced amnesia and the protective effect against hypoxia, respectively, in mice. Compound 3o, 1-(benzo[b]thiophen-5-yl)-2-(2-diethylaminoethoxy)ethanol, showed the best AA and AH activity profile, being superior to our prototype compound, 2-(2-dimethylaminoethoxy)-1-phenylethanol (1). Elongation of the ethylene linkage in the side chain of 3o to 3- and 4-carbon moieties brought about a significant decrease in AH activity. Compound 3o was further investigated for its protective effect against CO2-induced memory impairment and for acute toxicity in mice. It is ten-fold more potent than tacrine in the amnesia-reversal assay and is considerably less toxic than tacrine.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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Copper-Catalyzed C2 and C3 Phosphonation of Benzofuran and Benzothiophene with Trialkyl Phosphites

A strategy for the selective phosphonation of benzofuran and benzothiophene with trialkyl phosphites was developed. In these reactions, the C?H phosphonation of benzofurans or benzothiophenes at the C2 or C3 position with trialkyl phosphites was successfully achieved without directing groups by using a copper catalyst. Additionally, the C5 phosphonation of furan was successful under the same conditions.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem