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Benzothienyloxy phenylpropanamines, novel dual inhibitors of serotonin and norepinephrine reuptake

A series of benzothienyloxy phenylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. A series of benzothienyloxy propylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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gamma-Radiolysis of Aqueous Benzothiophene Solutions

gamma-Radiolysis of aqueous benzothiophene solutions saturated with N2O has been studied.In the absence of other reagents, the only products detected are 2- and 3-hydroxybenzothiophene and their corresponding lactonic and ketonic tautomers and a small amount of dimeric species.In the presence of potassium hexacyanoferrate or sodium hydroxide, however, products attributable to hydroxylation at all six available carbon sites are detected and dimer formation is reduced.Analysis of the experimental data suggests that both benzothiophene and its hydroxylation products are efficient scavengers for the radiation-produced OH radicals and that the initial yield of hydroxylation products is equal to that of hydroxyl radicals.Consistent with the electrophilic characteristics of the OH radical, k(OH+C8H6S):k(OH+C8H5SOH)=0.5+/-0.1.All six available carbon sites are capable of forming OH adducts, but the radicals formed by addition to the 4, 5, 6, and 7 positions tend to revert to the original compound or its ion in a neutral or acidic medium.In the case of the adducts formed by addition to the thiophene ring, on the other hand, the 3 position is seen to be favored, possibly as the result of the preservation of the aromatic benzene resonance structure.

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Benzothiophene – Wikipedia,
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Final Thoughts on Chemistry for Benzo[b]thiophen-3(2H)-one

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Intramolecular S¡¤¡¤¡¤O chalcogen bond in thioindirubin

Results of X-ray diffraction study and quantum-chemical calculations revealed that molecular conformation of thioindirubin molecule creates suitable conditions for formation of intramolecular C-H¡¤¡¤¡¤O and S¡¤¡¤¡¤O interactions. Analysis of molecular electrostatic potential (MEP) demonstrates existence of two areas of positive MEP (sigma-holes) in the outermost part of the sulfur atom on the continuation of the lines of the C-S bonds. One of these sigma-holes is oriented toward region of negative MEP around the oxygen atom of carbonyl group. Such situation corresponds to formation of sigma-hole or chalcogen bond. Existence of both types of bonding interactions is confirmed by topological analysis of electron density distribution using “Atoms in Molecules” (AIM) theory. Energies of the C-H¡¤¡¤¡¤O hydrogen bond and the S¡¤¡¤¡¤O sigma-hole bond derived from AIM and NBO theories are very close.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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CYCLOCONDENSATION OF 3(2H)-BENZOTHIOPHENONE AND OXIDATION PRODUCTS OBTAINED DURING THESE REACTIONS

The cyclocondensation of 3(2H)-benzothiophenone under acidic conditions has been studied.The symmetrical cyclotrimer tris(benzothieno)<2,3:2',3':2'',3''>benzene was formed and under certain conditions also a rearranged cyclotrimer, tris(benzothieno)<2,3:2',3':3'',2''>benzene.The formation of cyclotrimers was accompanied by oxidative coupling products involving the initially formed dimeric compound, 3-hydroxy-2,3-bibenzothienyl.During several of these reactions, a novel heterocycle, tris(benzothieno)<3,2-b:2',3'-d:2'',3''-f>oxepin, was formed.The products were studied by mass spectrometry and fragmentation pathways were determined by a linked scanning technique.

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Extended knowledge of 310466-38-7

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Electric Literature of 310466-38-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.310466-38-7, Name is 4-Fluorobenzo[b]thiophene, molecular formula is C8H5FS. In a Article£¬once mentioned of 310466-38-7

Design and development of cyclometalated ruthenium complexes containing thiophenyl-pyridine ligand for dye-sensitized solar cells

Two new cyclometalated ruthenium sensitizers NC102 (1) and NC103 (2), where the two NCS- ligands of the N3 analog were replaced with the 2-thiophen-2-yl-pyridine and 2-benzo[b]thiophen-2-yl-pyridine ligands, respectively, were designed and synthesized for dye-sensitized solar cell applications. The effects of these two ligands on the photophysical behavior of ruthenium complexes were investigated by their optical, electrochemical, and photovoltaic properties. The sensitizer NC103 (2) with the fluoride substitution in the ligand exhibited the best cell performance with a short-circuit current (Jsc) of 9.45 mA/cm2, an open-circuit voltage (V oc) of 630 mV, and a fill factor (FF) of 0.71, giving an overall power conversion efficiency of (eta) 4.22% under simulated AM 1.5 irradiation.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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Synthetic Route of 346592-74-3, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 346592-74-3, Name is 7-Fluorobenzo[b]thiophene, molecular formula is C8H5FS. In a Patent£¬once mentioned of 346592-74-3

Use of histone deacetylase inhibitors for the care of Philadephia-negative myeloproliferative syndromes

The use of substances capable of inhibiting one or more enzymes of the histone deacetylase family (histone deacetylase inhibitors) for the therapeutic treatment of Philadelphia-negative myeloproliferative syndromes (polycythemia vera, essential thrombocythemia or idiopathic myelofibrosis) is described. The dosage of the above-mentioned substances is significantly lower than that normally used for the care of other tumor syndromes and may be from 10 to 150 mg/day/patient.

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Benzothiophene – Wikipedia,
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Archives for Chemistry Experiments of Benzo[b]thiophene-6-carbaldehyde

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SPIRO-OXADIAZOLINE COMPOUNDS AS AGONISTS OF alpha-7-NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel spiro-oxadiazoline compounds that are suitable as agonists or partial agonists of a7-nAChR, and pharmaceutical compositions of the same, methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering a spiro-oxadiazoline cx7-nAChR agonist or partial agonist, to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

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Benzothiophene – Wikipedia,
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Reference of 130-03-0, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 130-03-0, Benzo[b]thiophen-3(2H)-one, introducing its new discovery.

INHIBITORS OF ESTROGEN RECEPTOR ALPHA AND THEIR USE AS THERAPEUTICS FOR CANCER

This invention provides of compounds having structures of Formula A, uses of these compounds for treatment of various indications, including breast cancer, as well as methods of treatment involving these compounds.

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More research is needed about 346592-74-3

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INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE

Disclosed herein are carbonyl compounds of having the structural formula: or a pharmaceutically acceptable salt, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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GPR119 AGONIST

A compound represented by the formula (II) is a GPR119 agonist, and is used as an agent for treating diabetes: wherein each of R23, R24, and R25 is hydrogen, halogen, C1-8 alkyl, C1-8 alkoxy, C1-8 alkylsulfonyl, or the like; each of Q0 and T0 is CH2 or the like, or Q0 and T0 are combined to form CH=CH or the like; A0 is (CH2)p, C(O), or a bond; B0 is a bond or the like; one of U0 and V0 is N, and the other is CR31 or the like; each of X0 and Y0 is CH2CH2 or the like; Z0 is C(O)OR32 or the like; and each of R21 and R22 is hydrogen, a halogen atom, hydroxyl, C1-8 alkyl, or the like.

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Reference£º
Benzothiophene – Wikipedia,
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