Ding, Yuxin published the artcileSolvent-dependent metal-free chemoselective synthesis of benzimidazoles and 1,3,5-triarylbenzenes from 2-amino anilines and aryl alkyl ketones catalyzed by I2, Quality Control of 1468-83-3, the main research area is benzimidazole preparation chemoselective; amino aniline aryl alkyl ketone condensation iodine catalyst; triarylbenzene preparation chemoselective; aryl alkyl ketone cyclization iodine catalyst.
A solvent-dependent I2-catalyzed chemoselective reaction was developed for the synthesis of benzimidazoles I (R = H, Cl, Me; R1 = H, Cl, Me; R2 = Ph, 2-naphthyl, 3-thienyl, etc.) and 1,3,5-triarylbenzenes 1,3,5-(Ar)3C6H3 (Ar = Ph, 2-naphthyl, 3-thienyl, etc.) via the annulation of 2-amino anilines 1,2-(NH2)2-4-R-5-R1C6H2 and aryl alkyl ketones R2C(O)Me or the cyclization of aryl alkyl ketones ArC(O)Me, resp. With 1,4-dioxane as the solvent, sequential C-N bond formation followed by C(CO)-C(CH3) bond cleavage leads to the formation of benzimidazoles I in a highly selective manner while aldol-type self-condensation of aryl alkyl ketones predominates using PhNO2 or PhCl as the solvent to afford 1,3,5-triarylbenzenes.
Tetrahedron Letters published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Quality Control of 1468-83-3.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem