Category: benzothiophene

Fujimoto, Hayato published the artcileThree-Component Coupling of Acyl Fluorides, Silyl Enol Ethers, and Alkynes by P(III)/P(V) Catalysis, Related Products of benzothiophene, the main research area is diene preparation hydrovinylation phosphine catalyst; acyl fluoride silyl enol ether alkynoate three component coupling.

Authors report herein on the phosphine-catalyzed hydrovinylation reaction by three-component coupling of acyl fluorides, silyl enol ethers, and alkynoates. The key to the success of the reaction is the formal transmetalation between pentacoordinate P(V) species (i.e., fluorophosphorane) and a silyl enol ether, which allows for C-C bond formation between the polarity-mismatched sites. The bond formation that cannot be attained even by transition metal catalysis is accomplished by a P(III)/P(V) manifold.

Journal of the American Chemical Society published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent) (alkynoates). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Related Products of benzothiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Schiltz, Pauline published the artcileCobalt Complexes Supported by Phosphinoquinoline Ligands for the Catalyzed Hydrosilylation of Carbonyl Compounds, HPLC of Formula: 1468-83-3, the main research area is phosphinoquinoline cobalt complex preparation hydrosilylation ketone catalyst; alkoxysilane preparation hydrosilylation ketone acetophenone cobalt phosphinoquinoline catalyst; crystal mol structure cobalt phosphinoquinoline neutral cationic complex; P,N Ligand; catalysis; cobalt complexes; hydrosilylation; phosphinoquinoline.

Alkoxysilanes ArCHMeOSiHPh2 were prepared by hydrosilylation of acetophenones ArCOMe with SiH2Ph2 catalyzed by cobalt(II) 8-phosphinoquinoline (8-R2Pquin, L; R = iPr, Ph) complexes [(8-R2Pquin)CoBr2] and [(8-R2Pquin)2CoBr][PF6]. P,N phosphinoquinoline based ligands differing by the nature of the phosphorus substituent (iPr, Ph) were employed to synthesize a series of cobalt(II) complexes ([LCoBr2], [L2CoBr](PF6) and [L’2CoBr](PF6)). The complex [(8-Ph2Pquin)2CoBr][PF6] was obtained in high yield and characterized among others by X-ray anal. and elemental anal. Complex [(8-iPr2Pquin)2CoBr][PF6] showed a very good catalytic activity for the hydrosilylation of various ketones. The catalysis proceeds at a low catalytic loading (1 mol %) with only 1 equiv of Ph2SiH2 in mild conditions and was efficient with aliphatic or aromatic ketones giving moderate to excellent yields of the corresponding silylated ether.

Chemistry – A European Journal published new progress about Alkoxysilanes Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, HPLC of Formula: 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Zhan, Haosheng published the artcileIron-Catalysed Aerobic Oxidative C-C Bond Cleavage of Ketones for the Synthesis of Primary Amides, Category: benzothiophene, the main research area is primary amide preparation green chem chemoselective; ketone aerobic oxidative bond cleavage amination iron catalyst.

An iron-catalyzed aerobic oxidative C-C bond cleavage of ketones RC(O)R1 (R = 4-methoxyphenyl, Ph, thiophen-2-yl, etc.; R1 = R1 = Me, Et, n-Pr, pentyl, 2-oxopropyl) for the synthesis of primary amides RC(O)NH2 has been developed using TEMPO and oxygen as an oxidant. This reaction tolerates a wide range of substrates, and primary amides are obtained in good to excellent yields. Substrates with long-chain alkyl substituents could also be selectively cleaved and converted into the corresponding amides.

SynOpen published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Category: benzothiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Ding, Yuxin published the artcileSolvent-dependent metal-free chemoselective synthesis of benzimidazoles and 1,3,5-triarylbenzenes from 2-amino anilines and aryl alkyl ketones catalyzed by I2, Quality Control of 1468-83-3, the main research area is benzimidazole preparation chemoselective; amino aniline aryl alkyl ketone condensation iodine catalyst; triarylbenzene preparation chemoselective; aryl alkyl ketone cyclization iodine catalyst.

A solvent-dependent I2-catalyzed chemoselective reaction was developed for the synthesis of benzimidazoles I (R = H, Cl, Me; R1 = H, Cl, Me; R2 = Ph, 2-naphthyl, 3-thienyl, etc.) and 1,3,5-triarylbenzenes 1,3,5-(Ar)3C6H3 (Ar = Ph, 2-naphthyl, 3-thienyl, etc.) via the annulation of 2-amino anilines 1,2-(NH2)2-4-R-5-R1C6H2 and aryl alkyl ketones R2C(O)Me or the cyclization of aryl alkyl ketones ArC(O)Me, resp. With 1,4-dioxane as the solvent, sequential C-N bond formation followed by C(CO)-C(CH3) bond cleavage leads to the formation of benzimidazoles I in a highly selective manner while aldol-type self-condensation of aryl alkyl ketones predominates using PhNO2 or PhCl as the solvent to afford 1,3,5-triarylbenzenes.

Tetrahedron Letters published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Quality Control of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Szollosi, Gyoergy published the artcileHighly Enantioselective Transfer Hydrogenation of Prochiral Ketones Using Ru(II)-Chitosan Catalyst in Aqueous Media, HPLC of Formula: 1468-83-3, the main research area is benzylic alc enantioselective preparation; acetophenone cyclic aryl ketone enantioselective transfer hydrogen ruthenium catalyst; chitosan ruthenium complex preparation characterization enantioselective transfer hydrogenation catalyst.

In the presence of a chitosan complex of ruthenium generated either in situ or prepared from [RuCl2(p-cymene)]2 and chitosan, aryl Me ketones and cyclic aryl ketones underwent enantioselective transfer hydrogenation with sodium formate in aqueous isopropanol to yield (S)-benzylic alcs. α-Methylbenzyl alcs. were formed in up to 86% ee, while cyclic and heterocyclic ketones were formed in up to 97% ee; aryl alkyl and alkyl ketones were hydrogenated in lower enantioselectivities. The structure of the chitosan-bound ruthenium catalyst was studied; O-methylation of the catalyst did not yield an improved catalyst.

ChemCatChem published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, HPLC of Formula: 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Yang, Qing published the artcileMerrifield resin-supported quinone as an efficient biomimetic catalyst for metal-free, base-free, chemoselective synthesis of 2,4,6-trisubstituted pyridines, Product Details of C6H6OS, the main research area is pyridine chemoselective synthesis Merrifield resin supported quinone catalyst green.

Metal-free, base-free, biomimetic and chemoselective synthesis of 2,4,6-trisubstituted pyridines was developed under mild conditions for the first time. The heterogeneous biomimetic catalyst – recoverable Merrifield resin-supported quinone – was fully characterized by Fourier transform IR spectroscopy (FT-IR), X-ray photoelectron spectrometry (XPS) and energy dispersive X-ray spectroscopy (EDX). This supported quinone catalyst exhibited excellent catalytic reactivity for chemoselective synthesis of 2,4,6-trisubstituted pyridines, providing an efficient and green method for the synthesis of pyridine derivatives under mild conditions. Mechanistic investigations were conducted to gain insights into the heterogeneous biomimetic catalyst as well as the resulting transformation. The successful capture of intermediates offered direct and clear evidence for the proposed mechanism.

Green Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Product Details of C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Zhuang, Shi-Yi published the artcileCopper-catalyzed Oxidative C(sp3)-H/C(sp3)-H Cross-Coupling Reaction of 3-Methylbenzo[c]isoxazoles with Methyl Ketones: Access to Indigoid Analogues, Product Details of C6H6OS, the main research area is aryl methylketone benzoxazole copper tandem ring opening aza Michael; oxoindolinylidene ketone diastereoselective preparation.

A copper-catalyzed oxidative C(sp3)-H/C(sp3)-H cross-coupling reaction of Me ketones and 3-methylbenzo[c]isoxazoles was developed for the direct synthesis of 3-oxoindolin-2-ylidene derivatives This process involved an intermol. nucleophilic addition/ring-opening/aza-Michael addition cascade, providing indigoid analogs with high atom economy and as single isomers exclusively under mild conditions.

Journal of Organic Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Product Details of C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Zhuang, Shi-Yi published the artcileCopper-catalyzed Reaction of Anthranils with Methyl Ketones: Site-Selective C5-Dicarbonylation of Anthranils, Synthetic Route of 1468-83-3, the main research area is diketone preparation regioselective; anthranil aryl methyl ketone dicarbonylation copper catalyst.

A copper-catalyzed site-selective C5-dicarbonylation reaction of 2,1-benzisoxazole has been developed for synthesis of 1,2-dicarbonyl compounds RC(O)C(O)R1 (R = C6H5, 4-FC6H4, 2-thienyl, etc.; R1 = 4-amino-3-formylphenyl) using Me ketones RC(O)Me as a com. available carbonylation reagent. This process represents the first example to implement the C5-dicarbonylation of anthranils, which involves an oxidative Csp3-H/Csp2-H cross-coupling reaction along with thermolytic N-O bond cleavage.

Advanced Synthesis & Catalysis published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Synthetic Route of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Zhou, You published the artcileI2-Promoted site-selective C-C bond cleavage of aryl methyl ketones as C1 synthons for constructing 5-acyl-1H-pyrazolo[3,4-b]pyridines, Application In Synthesis of 1468-83-3, the main research area is aryl methyl ketone aminopyrazole enaminone iodine cleavage cyclization; pyrazolopyridine regioselective preparation.

A novel iodine promoted [1 + 3 + 2] cleavage cyclization reaction for the synthesis of 1H-pyrazolo[3,4-b]pyridines from aryl Me ketones, 5-aminopyrazoles and enaminones was established. This transition metal-free catalysis method has simple reaction conditions and good substrate compatibility, and was demonstrated in the transformation of alkyl and natural mol.-derived enaminones. Mechanistic studies showed that two cyclization pathways affording different key intermediates were involved, but affording the same target product after site-selective cleavage of the unstrained C-C bond of the acyl group.

Organic Chemistry Frontiers published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Application In Synthesis of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Qin, Zemin published the artcileCo(II)-Catalyzed Oxidation of N,N-Dimethylaminoethanol: An Efficient Synthesis of Unsymmetrical (2,4-) and Symmetrical (2,6-) Diarylpyridines through Annulation of Aromatic Ketones with a Nitrogen Source, SDS of cas: 1468-83-3, the main research area is diarylpyridine preparation; aromatic ketone dimethylaminoethanol pseudo multicomponent one pot annulation.

An efficient and facile synthesis of 2,4- and 2,6-diarylpyridines has been developed. It involves one-pot [2+2+1+1] pseudo four-component annulation of aromatic ketones, a nitrogen source and a carbon donor. N,N-Dimethylaminoethanol is oxidized in the presence of Co(II) to provide a carbon synthon. Two C-C and two C-N bonds are formed during the oxidative annulation process. The products are strictly controlled due to the steric hindrance: 2,4-diarylpyridines are afforded effectively with small ketones while 2,6-diaryl analogs predominate when bulky ketones are employed.

Asian Journal of Organic Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, SDS of cas: 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem